The goal of the Training Program in Cancer Biochemistry and Cell Biology is to provide predoctoral and postdoctoral trainees with a comprehensive orientation to cancer in order to enhance their training experience in cancer research. The Training Program is based in the Dept. of Molecular Genetics and Microbiology at Stony Brook University, nine of whose faculty are members of the Training Program. Eighteen additional faculty join the Program from other departments at Stony Brook University, Cold Spring Harbor Laboratory, and Brookhaven National Laboratory. The Training Program represents a broad range of research interests related to cancer including cell cycle control, signal transduction, cancer genetics and apoptosis, regulation of gene expression, cell cycle regulation of DNA replication, and protein structure function analysis. The Program trains predoctoral students and postdoctoral fellows for a career in cancer research. Each trainee will be supported for a two to three year period. The predoctoral Training Program provides lecture and laboratory courses that prepare students for dissertation research. Only predoctoral students who have been advanced to Ph.D. candidacy are eligible for appointment to the Training Program. Predoctoral students and postdoctoral fellows in the Training Program are exposed to the clinical side of cancer and to activities that promote translational cancer research. These include a Cancer Cell Biology course, attendance at meetings of the Hematology/Oncology Clinical Fellows Program, and at monthly meetings sponsored by the Stony Brook University Cancer Center where clinical and basic research faculty, fellows and students meet to discuss translational research opportunities in cancer. The training environment for predoctoral and postdoctoral trainees includes active seminar series, research symposia and conferences held at Stony Brook University, Cold Spring Harbor Laboratory, and Brookhaven National Laboratory. These three institutions provide world-class environments in support of these training efforts. There are numerous formal and informal interactions among the faculty in the Training Program and a wide range of collaborative projects are evident. The Program provides outstanding training in cancer biochemistry and cell biology to expose trainees to a broad perspective in cancer research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA009176-35
Application #
8300156
Study Section
Subcommittee G - Education (NCI)
Program Officer
Lim, Susan E
Project Start
1993-04-01
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2014-06-30
Support Year
35
Fiscal Year
2012
Total Cost
$423,673
Indirect Cost
$33,497
Name
State University New York Stony Brook
Department
Genetics
Type
Schools of Medicine
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794
Catanzaro, Joseph M; Sheshadri, Namratha; Pan, Ji-An et al. (2014) Oncogenic Ras induces inflammatory cytokine production by upregulating the squamous cell carcinoma antigens SerpinB3/B4. Nat Commun 5:3729
Ueki, Nobuhide; Lee, Siyeon; Sampson, Nicole S et al. (2013) Selective cancer targeting with prodrugs activated by histone deacetylases and a tumour-associated protease. Nat Commun 4:2735
Gilmore, Sarah A; Naseem, Shamoon; Konopka, James B et al. (2013) N-acetylglucosamine (GlcNAc) triggers a rapid, temperature-responsive morphogenetic program in thermally dimorphic fungi. PLoS Genet 9:e1003799
Samaniego, Sylvia; Marcu, Kenneth B (2013) IKK? in myeloid cells controls the host response to lethal and sublethal Francisella tularensis LVS infection. PLoS One 8:e54124
Marcelain, Katherine; Armisen, Ricardo; Aguirre, Adam et al. (2012) Chromosomal instability in mouse embryonic fibroblasts null for the transcriptional co-repressor Ski. J Cell Physiol 227:278-87
Vink, Elizabeth I; Yondola, Mark A; Wu, Kai et al. (2012) Adenovirus E4-ORF3-dependent relocalization of TIF1ýý and TIF1ýý relies on access to the Coiled-Coil motif. Virology 422:317-25
Catanzaro, Joseph M; Guerriero, Jennifer L; Liu, Jingxuan et al. (2011) Elevated expression of squamous cell carcinoma antigen (SCCA) is associated with human breast carcinoma. PLoS One 6:e19096
Ullman, Erica; Pan, Ji-An; Zong, Wei-Xing (2011) Squamous cell carcinoma antigen 1 promotes caspase-8-mediated apoptosis in response to endoplasmic reticulum stress while inhibiting necrosis induced by lysosomal injury. Mol Cell Biol 31:2902-19
Pan, Ji-An; Ullman, Erica; Dou, Zhixun et al. (2011) Inhibition of protein degradation induces apoptosis through a microtubule-associated protein 1 light chain 3-mediated activation of caspase-8 at intracellular membranes. Mol Cell Biol 31:3158-70
Rana, Nadia A; Nita-Lazar, Aleksandra; Takeuchi, Hideyuki et al. (2011) O-glucose trisaccharide is present at high but variable stoichiometry at multiple sites on mouse Notch1. J Biol Chem 286:31623-37

Showing the most recent 10 out of 121 publications