The goal of this training grant continues to be the training of pre and post-doctoral students in the discipline of cancer biology research so that they can participate in finding solutions to the problems associated with human cancer. The approach to this training involves didactic instruction, seminars and laboratory-based research. The training program is interdisciplinary as evidenced by the participation of 36 faculty in twelve different Departments in four different Colleges. The predoctoral trainees will all be in the Cancer Biology Graduate Interdisciplinary Program. Students in the Cancer Biology Graduate Program are required to take specific courses in cancer causation, epidemiology and prevention and treatment. Training for predoctoral students also involves other course requirements including the Cancer Biology Seminar Series, a Science, Society and Ethics course and a Clinical Cancer Biology Experience course. The six predoctoral positions will be awarded to Cancer Biology students who have identified a mentor and have started their dissertation research. They,will"besupported by the Training Grant for two years. The training grant also provides stipend support for four postdoctoral fellows. These positions are awarded for two years and are selected by the Trainee,Selection Subcommittee as are the six predoctoral trainees from a pool of applicants once a year. The postdoctoral trainees are required to participate in the Cancer Biology Seminar Series, encouraged to take the Clinical Cancer Biology Experience course and to identify a mentoring committee. The research training occurs in laboratories controlled by individual faculty who are in the Colleges of Medicine, Pharmacy Agriculture and Life Sciences or Faculty of Science. These laboratories include common and core facilities provided by individual Departments as well as the Arizona Cancer Center and the Southwest Center for Toxicology. A unique feature of the training program continues to be research training opportunities that emphasize combined laboratory and clinic-based research. The intent of the Cancer Biology T32 Training Program is to train the next generation of cancer researchers who will be successful in preventing and curing human cancers in the 21st century.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA009213-35
Application #
8257552
Study Section
Subcommittee G - Education (NCI)
Program Officer
Lim, Susan E
Project Start
1983-09-01
Project End
2014-04-30
Budget Start
2012-05-01
Budget End
2014-04-30
Support Year
35
Fiscal Year
2012
Total Cost
$422,667
Indirect Cost
$29,798
Name
University of Arizona
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Alizadeh, Darya; Larmonier, Nicolas (2014) Chemotherapeutic targeting of cancer-induced immunosuppressive cells. Cancer Res 74:2663-8
Kendrick, Samantha L; Redd, Lucas; Muranyi, Andrea et al. (2014) BCL2 antibodies targeted at different epitopes detect varying levels of protein expression and correlate with frequent gene amplification in diffuse large B-cell lymphoma. Hum Pathol 45:2144-53
Gustafson, Heather L; Yao, Song; Goldman, Bryan H et al. (2014) Genetic polymorphisms in oxidative stress-related genes are associated with outcomes following treatment for aggressive B-cell non-Hodgkin lymphoma. Am J Hematol 89:639-45
Hanke, Neale T; LaCasse, Collin J; Larmonier, Claire B et al. (2014) PIAS1 and STAT-3 impair the tumoricidal potential of IFN-?-stimulated mouse dendritic cells generated with IL-15. Eur J Immunol 44:2489-99
Kusne, Yael; Carrera-Silva, Eugenio A; Perry, Anthony S et al. (2014) Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNF? in glioblastoma. Sci Signal 7:ra75
Briehl, Margaret M; Tome, Margaret E; Wilkinson, Sarah T et al. (2014) Mitochondria and redox homoeostasis as chemotherapeutic targets. Biochem Soc Trans 42:939-44
Kendrick, Samantha; Kang, Hyun-Jin; Alam, Mohammad P et al. (2014) The dynamic character of the BCL2 promoter i-motif provides a mechanism for modulation of gene expression by compounds that bind selectively to the alternative DNA hairpin structure. J Am Chem Soc 136:4161-71
Kang, Hyun-Jin; Kendrick, Samantha; Hecht, Sidney M et al. (2014) The transcriptional complex between the BCL2 i-motif and hnRNP LL is a molecular switch for control of gene expression that can be modulated by small molecules. J Am Chem Soc 136:4172-85
Alizadeh, Darya; Trad, Malika; Hanke, Neale T et al. (2014) Doxorubicin eliminates myeloid-derived suppressor cells and enhances the efficacy of adoptive T-cell transfer in breast cancer. Cancer Res 74:104-18
Onyeagucha, Benjamin Chidi; Mercado-Pimentel, Melania E; Hutchison, Jennifer et al. (2013) S100P/RAGE signaling regulates microRNA-155 expression via AP-1 activation in colon cancer. Exp Cell Res 319:2081-90

Showing the most recent 10 out of 84 publications