The objective of this T32 training grant is to identify talented pre- and post-doctoral students and develop outstanding cancer biology researchers by placement in cancer biology laboratories that are conducting cutting edge research, development of a thorough cancer biology knowledge base with a thoughtfully constructed lecture schedule, and through skilled mentoring and evaluation. This Cancer Biology Training Grant (CBIO T32) is associated with a Cancer Biology Graduate Interdisciplinary Program (CBIO GIDP). The CBIO T32 has six predoctoral positions and four postdoctoral positions. Talented predoctoral students are admitted into the CBIO GIDP through an umbrella recruiting program and training grant eligible students in the CBIO GIDP are selected to be on the T32 through a competitive process. Postdoctoral trainees are selected through a competative process similar to that designed for predoctoral students. Students and trainees have 34 faculty researchers to choose from who are both skilled researchers and mentors. Our faculty are from 14 Departments and 5 different Colleges who provide a highly interdisciplinary and collaborative environment for our T32 appointees. Predoctoral student training involves didactic instruction in cancer causation, epidemiology and prevention and treatment through specific courses such as Basic Cancer Biology, Advanced Topics in Cancer Biology and our Cancer Biology Seminar Series. The Experimental Design and Grant Writing workshops are designed to complement the student's laboratory-based research and develop essential professional skills. Appreciation for the clinical challenges of cancer treatment is accomplished through a novel clinical experiences class taught by Cancer Center clinicians. The postdoctoral training program is more focused on laboratory-based research. However, postdoctoral trainees are also required to attend the CBIO seminars, attend both the Experimental Design and Grant Writing workshops, and to develop a career plan. Progress of students and trainees is ensured through regular mentoring committee meetings and annual evaluations by a progress committee. Our students and trainees emerge from this program with a thorough background in cancer biology and go on to become the next generation of cancer researchers who will be instrumental in preventing and curing human cancers.

Public Health Relevance

The goal of this training grant continues to be the training of pre- and post-doctoral trainees in cancer biology research to find solutions to the problems associated with human cancer. The approach to this training involves didactic instruction, seminars, colloquia and laboratory-based research. The intent of the Cancer Biology T32 Training Program is to train the next generation of cancer researchers who will be successful in preventing and curing human cancers in the 21st century.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Program Officer
Lim, Susan E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Arizona
Anatomy/Cell Biology
Schools of Medicine
United States
Zip Code
Alizadeh, Darya; Larmonier, Nicolas (2014) Chemotherapeutic targeting of cancer-induced immunosuppressive cells. Cancer Res 74:2663-8
Kendrick, Samantha L; Redd, Lucas; Muranyi, Andrea et al. (2014) BCL2 antibodies targeted at different epitopes detect varying levels of protein expression and correlate with frequent gene amplification in diffuse large B-cell lymphoma. Hum Pathol 45:2144-53
Gustafson, Heather L; Yao, Song; Goldman, Bryan H et al. (2014) Genetic polymorphisms in oxidative stress-related genes are associated with outcomes following treatment for aggressive B-cell non-Hodgkin lymphoma. Am J Hematol 89:639-45
Hanke, Neale T; LaCasse, Collin J; Larmonier, Claire B et al. (2014) PIAS1 and STAT-3 impair the tumoricidal potential of IFN-?-stimulated mouse dendritic cells generated with IL-15. Eur J Immunol 44:2489-99
Kusne, Yael; Carrera-Silva, Eugenio A; Perry, Anthony S et al. (2014) Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNF? in glioblastoma. Sci Signal 7:ra75
Briehl, Margaret M; Tome, Margaret E; Wilkinson, Sarah T et al. (2014) Mitochondria and redox homoeostasis as chemotherapeutic targets. Biochem Soc Trans 42:939-44
Kendrick, Samantha; Kang, Hyun-Jin; Alam, Mohammad P et al. (2014) The dynamic character of the BCL2 promoter i-motif provides a mechanism for modulation of gene expression by compounds that bind selectively to the alternative DNA hairpin structure. J Am Chem Soc 136:4161-71
Kang, Hyun-Jin; Kendrick, Samantha; Hecht, Sidney M et al. (2014) The transcriptional complex between the BCL2 i-motif and hnRNP LL is a molecular switch for control of gene expression that can be modulated by small molecules. J Am Chem Soc 136:4172-85
Alizadeh, Darya; Trad, Malika; Hanke, Neale T et al. (2014) Doxorubicin eliminates myeloid-derived suppressor cells and enhances the efficacy of adoptive T-cell transfer in breast cancer. Cancer Res 74:104-18
Onyeagucha, Benjamin Chidi; Mercado-Pimentel, Melania E; Hutchison, Jennifer et al. (2013) S100P/RAGE signaling regulates microRNA-155 expression via AP-1 activation in colon cancer. Exp Cell Res 319:2081-90

Showing the most recent 10 out of 84 publications