The objective of the Ohio State University (OSU) postdoctoral oncology training program is to provide a focused perspective and state-of-the-art research training in cancer biology and aspects of cancer treatment to postdoctoral fellows selected from motivated and gifted M.D., D.O., DVM, or Ph.D. candidates who have strong interests in cancer research and are committed to careers in patient-oriented cancer research. The rationale of the program is that advances in cancer therapy and prevention are most likely to come from physician- scientists and basic scientists who have trained in a research environment that fosters collaboration between clinical and laboratory investigators focused on the pursuit of specific research goals. The participating faculty consists of the program director, chair of the advisory committee, director/assistant director of education, mentors and contributing faculty. The program design consists of formal academic courses, seminars and journal clubs to provide trainees with an overview of cancer biology and a broad cancer research orientation. Each trainee will perform independent research projects in a mentor's laboratory. In the 43-year history of this training grant at OSU, 154 postdoctoral students have been trained in basic and translational cancer research by a cadre of outstanding NIH funded participating faculty. Of these 154 trainees, ~85% have engaged in academic or industrial scientific pursuits for all or a significant portion of their careers after leaving the fellowship program, and this success rate has been sustained over the past 15 years of Dr. Caligiuri's tenure as PI of this award. The research areas and scientific disciplines encompassed by the 47 mentors and the 11 contributing faculty are represented by their individual affiliations with one of the six OSU Comprehensive Cancer Center (CCC) Research Programs: Molecular Biology and Cancer Genetics, Experimental Therapeutics, Immunology, Molecular Carcinogenesis and Chemoprevention, Oncogenic Virus and Cancer Control. Mentors and contributing faculty are all NIH/NCI/DOD/ACS-funded basic scientists and physician- investigators that have developed a network of collaborative interactions within the CCC allowing the trainee to be exposed to a multiple research perspectives and expertise. The T32 faculty participate with trainees in joint conferences which further enhance appreciation of different research approaches. The anticipated levels of experience of eligible postdoctoral candidates are two to seven years, and the duration of the proposed training is two years. This competitive renewal application seeks continued support again for 8 trainees each year for 5 years.

Public Health Relevance

of this grant proposal to Public Health is that advances in cancer therapy and prevention are most likely to come from physician-investigators and basic life scientists who have trained in a research environment that fosters collaboration between clinical and laboratory investigators focused on the pursuit of specific research goals.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Institutional National Research Service Award (T32)
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Study Section
Subcommittee G - Education (NCI)
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Damico, Mark W
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Ohio State University
Internal Medicine/Medicine
Schools of Medicine
United States
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Bolyard, Chelsea; Yoo, Ji Young; Wang, Pin-Yi et al. (2014) Doxorubicin synergizes with 34.5ENVE to enhance antitumor efficacy against metastatic ovarian cancer. Clin Cancer Res 20:6479-94
Wu, Dayong; Sunkel, Benjamin; Chen, Zhong et al. (2014) Three-tiered role of the pioneer factor GATA2 in promoting androgen-dependent gene expression in prostate cancer. Nucleic Acids Res 42:3607-22
Dubovsky, Jason A; Flynn, Ryan; Du, Jing et al. (2014) Ibrutinib treatment ameliorates murine chronic graft-versus-host disease. J Clin Invest 124:4867-76
Simmons, Jessica K; Dirksen, Wessel P; Hildreth 3rd, Blake E et al. (2014) Canine prostate cancer cell line (Probasco) produces osteoblastic metastases in vivo. Prostate 74:1251-65
Mace, Thomas A; King, Samantha A; Ameen, Zeenath et al. (2014) Bioactive compounds or metabolites from black raspberries modulate T lymphocyte proliferation, myeloid cell differentiation and Jak/STAT signaling. Cancer Immunol Immunother 63:889-900
Liebner, David A; Huang, Kun; Parvin, Jeffrey D (2014) MMAD: microarray microdissection with analysis of differences is a computational tool for deconvoluting cell type-specific contributions from tissue samples. Bioinformatics 30:682-9
Markowitz, Joseph; Luedke, Eric A; Grignol, Valerie P et al. (2014) A phase I trial of bortezomib and interferon-*-2b in metastatic melanoma. J Immunother 37:55-62
Huang, Xiaomeng; Schwind, Sebastian; Yu, Bo et al. (2013) Targeted delivery of microRNA-29b by transferrin-conjugated anionic lipopolyplex nanoparticles: a novel therapeutic strategy in acute myeloid leukemia. Clin Cancer Res 19:2355-67
Mahoney, Emilia; Byrd, John C; Johnson, Amy J (2013) Autophagy and ER stress play an essential role in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol. Autophagy 9:434-5
Dubovsky, Jason A; Beckwith, Kyle A; Natarajan, Gayathri et al. (2013) Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes. Blood 122:2539-49

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