This proposal requests renewal of support for a postdoctoral training program, now in its 28th year, at the NCI designated Basic Cancer Center of the Salk Institute for Biological Studies. This program provides advanced training in research to postdoctoral scientists pursuing careers in basic and translational research related to cancer. Major activities include molecular, cell and developmental biology research within the three Cancer Center Programs: Metabolism and Cancer, Mouse Models and Cancer Stem Cells, and Growth Control and Genomic Stability. The Cancer Center occupies 73,000 sq. ft. of laboratory space and includes 32 faculty members, 22 of whom are members of the training faculty. Currently there are 187 postdoctoral and 58 predoctoral trainees in the Cancer Center. Trainees devote 100% of their time to research. Trainees in the program also participate in a variety of special activities designed to enhance their knowledge of cancer biology and therapeutic applications of basic research. These include the Cancer Biology Course, Cancer Forum and Cancer Center Symposium. These activities are designed to significantly augment the cancer relevance and focus of the individual laboratory training experience. We request funding to continue to support six trainees. The trainees will hold Ph.D. and/or M.D. degrees, and will be chosen on the basis of the quality and cancer relevance of research proposals they submit. The average duration of training will be three years, as at present. Upon completion of training the trainees will be fully qualified to conduct independent research in molecular and cellular biology related to cancer.

Public Health Relevance

The Cancer Center of the Salk Institute for Biological Studies provides a rich environment for postdoctoral research training for qualified candidates with the Ph.D. and/or M.D. degrees. Trainees are prepared for careers as independent research investigators through firsthand experience designing and performing cutting edge research in basic and translational studies in cancer biology. The Cancer Center Training Program also provides courses, seminars, and a forum for research discussions to enhance this training experience. The written critiques and criteria scores of individual reviewers are provided in essentially unedited form in the Critique section below. Please note that these critiques and criteria scores were prepared prior to the meeting and may not have been revised subsequent to any discussions at the review meeting. The Resume and Summary of Discussion above summarizes the final opinions of the committee.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA009370-33
Application #
8715693
Study Section
Special Emphasis Panel (ZCA1)
Program Officer
Lim, Susan E
Project Start
Project End
Budget Start
Budget End
Support Year
33
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Salk Institute for Biological Studies
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Young, Nathan P; Kamireddy, Anwesh; Van Nostrand, Jeanine L et al. (2016) AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes. Genes Dev 30:535-52
Svensson, Robert U; Parker, Seth J; Eichner, Lillian J et al. (2016) Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models. Nat Med 22:1108-1119
Hernandez, Jeniffer B; Chang, Christina; LeBlanc, Mathias et al. (2015) The CREB/CRTC2 pathway modulates autoimmune disease by promoting Th17 differentiation. Nat Commun 6:7216
Egan, Daniel F; Chun, Matthew G H; Vamos, Mitchell et al. (2015) Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates. Mol Cell 59:285-97
Fuhs, Stephen Rush; Meisenhelder, Jill; Aslanian, Aaron et al. (2015) Monoclonal 1- and 3-Phosphohistidine Antibodies: New Tools to Study Histidine Phosphorylation. Cell 162:198-210
Rising, Kathleen A; Crenshaw, Charisse M; Koo, Hyun Jo et al. (2015) Formation of a Novel Macrocyclic Alkaloid from the Unnatural Farnesyl Diphosphate Analogue Anilinogeranyl Diphosphate by 5-Epi-Aristolochene Synthase. ACS Chem Biol 10:1729-36
Dravis, Christopher; Spike, Benjamin T; Harrell, J Chuck et al. (2015) Sox10 Regulates Stem/Progenitor and Mesenchymal Cell States in Mammary Epithelial Cells. Cell Rep 12:2035-48
Mouchiroud, Laurent; Eichner, Lillian J; Shaw, Reuben J et al. (2014) Transcriptional coregulators: fine-tuning metabolism. Cell Metab 20:26-40
Sherman, Mara H; Yu, Ruth T; Engle, Dannielle D et al. (2014) Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell 159:80-93
Rodgers, Melissa J; Banks, David J; Bradley, Kenneth A et al. (2014) CHD1 and CHD2 are positive regulators of HIV-1 gene expression. Virol J 11:180

Showing the most recent 10 out of 66 publications