The Eppley Institute is an academic unit of the University of Nebraska Medical Center (UNMC) with its sole focus on cancer research. It is a major component of the NCI-designated UNMC Eppley Cancer Center, which is the only NCI-designated cancer center in a five state region from North Dakota to Texas. As such, the Eppley Institute and the Cancer Biology Training Program (CBTP) play an important regional role in training future basic and clinical scientists. We recruit from a national pool of predoctoral and postdoctoral fellows. The NCI Training Grant supports a key part of the CBTP, which currently has 39 predoctoral and 33 postdoctoral fellows in training. The CBTP faculty has a wide variety of expertise in areas important for a broad-based cancer biology training program, including biochemistry, molecular, cellular and structural biology, drug delivery, genetics, immunology, medicinal chemistry, pathology, pharmaceutics, and clinical oncology. A number of our trainees are directly involved in translational research activities, e.g. role of catechol estrogens in human breast cancer, tumor vaccine development, development of tumor markers for gastrointestinal and oral cavity malignancies, and a Rapid Pancreatic Autopsy Program for harvesting entire organs and selected tissue samples from patients who die of pancreatic adenocarcinoma. The goal of the training grant is to provide each doctoral student and postdoctoral fellow with the knowledge base, laboratory skills, and problem solving abilities to become independent, innovative cancer investigators.
The specific aims of the CBTP are to provide pre-and postdoctoral trainees with: (1) knowledge of the mechanisms of carcinogenesis, the pathology of human cancer, and the potential for cancer prevention;(2) an in depth background in the areas of basic science (biochemistry, molecular and cellular biology, genetics, immunology, pharmacology, pharmaceutical sciences) that is necessary to study and understand the conversion of normal cells to cancer cells and to design methods of diagnosis and treatment;(3) the ability to apply this information to plan and conduct innovative research on the causes, prevention, diagnosis, and treatment of cancer;and (4) an appreciation of the power of interdisciplinary research. To achieve these aims, the CBTP must be able to attract highly-qualified and motivated graduate students and postdoctoral fellows and provide them with high quality didactic and laboratory experiences.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA009476-23
Application #
8292221
Study Section
Subcommittee G - Education (NCI)
Program Officer
Damico, Mark W
Project Start
1997-08-22
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2014-06-30
Support Year
23
Fiscal Year
2012
Total Cost
$335,830
Indirect Cost
$21,626
Name
University of Nebraska Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
168559177
City
Omaha
State
NE
Country
United States
Zip Code
68198
Burchett, Katrina M; Etekpo, Asserewou; Batra, Surinder K et al. (2017) Inhibitors of telomerase and poly(ADP-ribose) polymerases synergize to limit the lifespan of pancreatic cancer cells. Oncotarget 8:83754-83767
Griess, Brandon; Tom, Eric; Domann, Frederick et al. (2017) Extracellular superoxide dismutase and its role in cancer. Free Radic Biol Med 112:464-479
Mertz, T M; Baranovskiy, A G; Wang, J et al. (2017) Nucleotide selectivity defect and mutator phenotype conferred by a colon cancer-associated DNA polymerase ? mutation in human cells. Oncogene 36:4427-4433
Neilsen, Beth K; Frodyma, Danielle E; Lewis, Robert E et al. (2017) KSR as a therapeutic target for Ras-dependent cancers. Expert Opin Ther Targets 21:499-509
Arnst, Jamie L; Hein, Ashley L; Taylor, Margaret A et al. (2017) Discovery and characterization of small molecule Rac1 inhibitors. Oncotarget 8:34586-34600
McGahan, Ben G; Neilsen, Beth K; Kelly, David L et al. (2017) Assessment of vascularity in glioblastoma and its implications on patient outcomes. J Neurooncol 132:35-44
Wuebben, Erin L; Rizzino, Angie (2017) The dark side of SOX2: cancer - a comprehensive overview. Oncotarget 8:44917-44943
Golden, Briana Ormsbee; Griess, Brandon; Mir, Shakeel et al. (2017) Extracellular superoxide dismutase inhibits hepatocyte growth factor-mediated breast cancer-fibroblast interactions. Oncotarget 8:107390-107408
Mohapatra, Bhopal; Zutshi, Neha; An, Wei et al. (2017) An essential role of CBL and CBL-B ubiquitin ligases in mammary stem cell maintenance. Development 144:1072-1086
R├Ądler, Patrick D; Wehde, Barbara L; Wagner, Kay-Uwe (2017) Crosstalk between STAT5 activation and PI3K/AKT functions in normal and transformed mammary epithelial cells. Mol Cell Endocrinol 451:31-39

Showing the most recent 10 out of 201 publications