This renewal application seeks support for the training of predoctoral students and postdoctoral fellows in biochemical, chemical, and structural approaches for cancer research. The training program integrates contemporary cancer biology (e.g., oncogenes and tumor suppressors, signal transduction, oncogenic transcription factors, DNA modifications, cell cycle control, genomic surveillance) with the allied fields of chemical and structural biology (high resolution analysis of proteins and DNA, carcinogenic DNA adducts, and chemotherapeutic drug design). Over the past 25 years, this Training Program has an outstanding training record and seeks to continue this multidisciplinary training program that is composed of 26 preceptors from nine academic departments and 2 programs representing both the Vanderbilt University School of Medicine and the College of Arts and Sciences. The training program is conducted within a vibrant academic environment and is supported by close interactions with the Vanderbilt-Ingram NCI-designated Comprehensive Cancer Center, the Vanderbilt Institute of Chemical Biology, and the Vanderbilt Center for Structural Biology, all of which offer resources for trainees and preceptors. In addition to departmental and preceptor-specific laboratory instruction, each trainee receives cancer-related training in the form of two courses focused on cancer biology and experimental cancer research. An Interdisciplinary Graduate Program, the Chemical and Physical Biology Program, and an independent graduate program in Chemistry all academically support predoctoral trainees. This renewal application highlights 8 new enhancements to our training program. An active mentoring program that includes former student trainees, postdoctoral mentors, and faculty mentors ensures the continued development of academic skills for cancer research and career development. Significant institutional investment in training programs, core facilities, state-of-the-art laboratories and equipment that provide technology resources applicable to cancer biology and molecular structures also enhance trainee development. Integrated training in biochemistry, chemistry, structural biology, and cancer biology is critical to the molecular understanding of cancer and the development of new approaches to molecularly targeted therapeutics.

Public Health Relevance

This renewal application seeks support for the training of predoctoral students and postdoctoral fellows in biochemical, chemical, and structural approaches for cancer research. Integrated training in biochemistry, chemistry, structural biology, and cancer biology is critical to the molecular understanding of cancer and the development of new approaches to molecularly targeted therapeutics.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
2T32CA009582-26
Application #
8475149
Study Section
Subcommittee G - Education (NCI)
Program Officer
Damico, Mark W
Project Start
1987-06-01
Project End
2018-05-31
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
26
Fiscal Year
2013
Total Cost
$340,026
Indirect Cost
$20,534
Name
Vanderbilt University Medical Center
Department
Biochemistry
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Oviatt, Alexandria A; Kuriappan, Jissy A; Minniti, Elirosa et al. (2018) Polyamine-containing etoposide derivatives as poisons of human type II topoisomerases: Differential effects on topoisomerase II? and II?. Bioorg Med Chem Lett 28:2961-2968
Gonzalez, Eric; Johnson, Kevin M; Pallan, Pradeep S et al. (2018) Inherent steroid 17?,20-lyase activity in defunct cytochrome P450 17A enzymes. J Biol Chem 293:541-556
Neitzel, Leif R; Broadus, Matthew R; Zhang, Nailing et al. (2018) Characterization of a cdc14 null allele in Drosophila melanogaster. Biol Open 7:
Sanders, Charles R; Hutchison, James M (2018) Membrane properties that shape the evolution of membrane enzymes. Curr Opin Struct Biol 51:80-91
Panda, Anshuman; de Cubas, Aguirre A; Stein, Mark et al. (2018) Endogenous retrovirus expression is associated with response to immune checkpoint blockade in clear cell renal cell carcinoma. JCI Insight 3:
Kamp, Frits; Scheidt, Holger A; Winkler, Edith et al. (2018) Bexarotene Binds to the Amyloid Precursor Protein Transmembrane Domain, Alters Its ?-Helical Conformation, and Inhibits ?-Secretase Nonselectively in Liposomes. ACS Chem Neurosci 9:1702-1713
Arreola, Alexandra; Payne, Laura Beth; Julian, Morgan H et al. (2018) Von Hippel-Lindau mutations disrupt vascular patterning and maturation via Notch. JCI Insight 3:
Jiang, Yanwen; Ortega-Molina, Ana; Geng, Huimin et al. (2017) CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas. Cancer Discov 7:38-53
Li, Cunxi; Singh, Bhuminder; Graves-Deal, Ramona et al. (2017) Three-dimensional culture system identifies a new mode of cetuximab resistance and disease-relevant genes in colorectal cancer. Proc Natl Acad Sci U S A 114:E2852-E2861
Liu, Qi; Wang, Jing; Zhao, Yue et al. (2017) Identification of active miRNA promoters from nuclear run-on RNA sequencing. Nucleic Acids Res 45:e121

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