This renewal application seeks continuing support for the """"""""Microenvironmental Influences in Cancer"""""""" Training Program (MICTP) at Vanderbilt University. Over the past 24 years and continuing with the 5-year period preceding this competitive renewal, we have been remarkably successful in recruiting and training excellent students and postdoctoral fellows, particularly those from groups underrepresented in science. Overall, the MIC training program encompasses a group of 26 faculty members from both the Vanderbilt University School of Medicine and the Meharry Medical College. The training program is conducted within a vibrant academic environment and is supported by close interactions with the Vanderbilt-lngram Comprehensive Cancer Center, the Vanderbilt Department of Cancer Biology, and the Vanderbilt-Meharry Alliance Program. In addition to departmental and preceptor-specific laboratory instruction, each trainee receives cancer-related training in the form of two courses focused on cancer biology, a grant workshop, an annual Tumor-Host Interaction Program retreat, and a """"""""Clinical Experience"""""""". Trainees within the program are actively mentored by both faculty members and through """"""""paired peer mentoring"""""""" by former student and postdoctoral trainees. Furthermore, predoctoral students are supported by an Interdisciplinary Graduate Program and an independent graduate program in Cancer Biology. Postdoctoral trainees are supported by an institutional Office of Postdoctoral Affairs, which provides both financial and academic support as well as career development advice and opportunities. Significant institutional investment in training programs, core facilities, state-of the-art laboratories and equipment further enhances trainee development. Training in this critical area of cancer research is necessary to build the workforce required to understand the complexities of the microenvironmental influence on cancer development and progression, and to translate this information into more effective and less toxic approaches to the treatment and prevention of cancer. Furthermore, training in tumor microenvironment will prepare our students and postdoctoral fellows to solve the major unsolved or neglected problems, """"""""the provocative questions"""""""", in oncology.

Public Health Relevance

One of the rapidly developing frontiers in cancer research is the tumor microenvironment. Training in this critical area of cancer research is necessary to build the workforce required to understand the complexities of the microenvironmental influence on cancer development and progression, and to translate this information into more effective and less toxic approaches to the treatment and prevention of cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
3T32CA009592-27S1
Application #
8840343
Study Section
Subcommittee G - Education (NCI)
Program Officer
Ogunbiyi, Peter
Project Start
1997-08-15
Project End
2018-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
27
Fiscal Year
2014
Total Cost
$29,456
Indirect Cost
$2,134
Name
Vanderbilt University Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Childress, Merrida A; Himmelberg, Stephen M; Chen, Huiqin et al. (2018) ALK Fusion Partners Impact Response to ALK Inhibition: Differential Effects on Sensitivity, Cellular Phenotypes, and Biochemical Properties. Mol Cancer Res 16:1724-1736
Fröse, Julia; Chen, Michelle B; Hebron, Katie E et al. (2018) Epithelial-Mesenchymal Transition Induces Podocalyxin to Promote Extravasation via Ezrin Signaling. Cell Rep 24:962-972
Doxie, Deon B; Greenplate, Allison R; Gandelman, Jocelyn S et al. (2018) BRAF and MEK inhibitor therapy eliminates Nestin-expressing melanoma cells in human tumors. Pigment Cell Melanoma Res 31:708-719
Almodovar, Karinna; Iams, Wade T; Meador, Catherine B et al. (2018) Longitudinal Cell-Free DNA Analysis in Patients with Small Cell Lung Cancer Reveals Dynamic Insights into Treatment Efficacy and Disease Relapse. J Thorac Oncol 13:112-123
Hebron, Katie E; Li, Elizabeth Y; Arnold Egloff, Shanna A et al. (2018) Alternative splicing of ALCAM enables tunable regulation of cell-cell adhesion through differential proteolysis. Sci Rep 8:3208
Short, Sarah P; Kondo, Jumpei; Smalley-Freed, Whitney G et al. (2017) p120-Catenin is an obligate haploinsufficient tumor suppressor in intestinal neoplasia. J Clin Invest 127:4462-4476
Kim, L C; Cook, R S; Chen, J (2017) mTORC1 and mTORC2 in cancer and the tumor microenvironment. Oncogene 36:2191-2201
Udyavar, Akshata R; Wooten, David J; Hoeksema, Megan et al. (2017) Novel Hybrid Phenotype Revealed in Small Cell Lung Cancer by a Transcription Factor Network Model That Can Explain Tumor Heterogeneity. Cancer Res 77:1063-1074
Enyindah-Asonye, Gospel; Li, Yan; Ruth, Jeffrey H et al. (2017) CD318 is a ligand for CD6. Proc Natl Acad Sci U S A 114:E6912-E6921
Edwards, Deanna N; Ngwa, Verra M; Wang, Shan et al. (2017) The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ. Sci Signal 10:

Showing the most recent 10 out of 242 publications