The Department of Surgery at the Washington University School of Medicine in St. Louis (WUSM) requests continued funding to support a training grant in surgical oncology for surgical residents who are planning careers devoted to oncology in the specialties of general, pediatric, and thoracic surgery. Additionally, we are specifically asking for two additional dedicated positions to support trainees in gynecologic oncology. This grant will support a comprehensive educational program in laboratory research in cell and developmental biology, immunobiology, molecular biology and molecular genetics/genomics. Three to five surgical residents and two gynecologic fellows will be selected annually for this research training program through a rigorous and highly competitive process. The selection committee is composed of the program director of the training grant as well as an advisory committee. The majority of the surgical oncology trainees will be from the WUSM surgical residency. Two slots per year will be for Gynecology fellows. The long-term objective of this program is to prepare surgical/gynecology trainees, through intensive educational programs and monitored experiences in investigative research to become independent scientific investigators and to acquire faculty positions in academic departments as well as to become leading physician scientists. The success of this program is attested to by the fact that of 16 residents who have completed the program over the past 10 years, ten (62.5 percent) now hold full-time faculty positions, several with peer-reviewed funding. The Department of Surgery at WUSM has approximately 45,000 nsf of laboratory research space and over $22 million of peer-reviewed annual research support plus $2.5 million of annual clinical research support. The participating faculty have grant support in excess of $45 million. Adding to this superb environment is the Siteman Cancer Center (SCC) which is an NCI designated comprehensive cancer center. The Center treats 7,000 cancer cases annually and receives approximately $130 million of annual grant support.

Public Health Relevance

This grant provides surgical/gynecologic trainees with all of the training to become independent scientific investigators and to obtain faculty positions in academic departments. With this training, they are poised to become the future leading physician scientists in this field.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA009621-23
Application #
8113300
Study Section
Subcommittee G - Education (NCI)
Program Officer
Damico, Mark W
Project Start
1988-07-05
Project End
2014-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
23
Fiscal Year
2011
Total Cost
$390,443
Indirect Cost
Name
Washington University
Department
Surgery
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Nywening, Timothy M; Belt, Brian A; Cullinan, Darren R et al. (2018) Targeting both tumour-associated CXCR2+ neutrophils and CCR2+ macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma. Gut 67:1112-1123
Barron, Lauren; Courtney, Cathleen; Bao, James et al. (2018) Intestinal resection-associated metabolic syndrome. J Pediatr Surg 53:1142-1147
Meyer, Melissa A; Baer, John M; Knolhoff, Brett L et al. (2018) Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance. Nat Commun 9:1250
Sharma, Piyush K; Dmitriev, Igor P; Kashentseva, Elena A et al. (2018) Development of an adenovirus vector vaccine platform for targeting dendritic cells. Cancer Gene Ther 25:27-38
Ethun, Cecilia G; Lopez-Aguiar, Alexandra G; Anderson, Douglas J et al. (2018) Transplantation Versus Resection for Hilar Cholangiocarcinoma: An Argument for Shifting Treatment Paradigms for Resectable Disease. Ann Surg 267:797-805
Salles, Arghavan; Wright, Robert C; Milam, Laurel et al. (2018) Social Belonging as a Predictor of Surgical Resident Well-being and Attrition. J Surg Educ :
Chapman Jr, William C; Choi, Pamela; Hawkins, Alexander T et al. (2018) Benchmarking rectal cancer care: institutional compliance with a longitudinal checklist. J Surg Res 225:142-147
Hudson, Jessica L; Bell, Jennifer M; Crabtree, Traves D et al. (2018) Office-Based Spirometry: A New Model of Care in Preoperative Assessment for Low-Risk Lung Resections. Ann Thorac Surg 105:279-286
Rosen, David R; Wolfe, Rachel C; Damle, Aneel et al. (2018) Thoracic Epidural Analgesia: Does It Enhance Recovery? Dis Colon Rectum 61:1403-1409
Durai, Vivek; Bagadia, Prachi; BriseƱo, Carlos G et al. (2018) Altered compensatory cytokine signaling underlies the discrepancy between Flt3-/- and Flt3l-/- mice. J Exp Med 215:1417-1435

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