The Department of Surgery at the Washington University School of Medicine in St. Louis (WUSM) requests continued funding to support a training grant in surgical oncology for surgical residents who are planning careers devoted to oncology in the specialties of general, pediatric, and thoracic surgery. Additionally, we are specifically asking for two additional dedicated positions to support trainees in gynecologic oncology. This grant will support a comprehensive educational program in laboratory research in cell and developmental biology, immunobiology, molecular biology and molecular genetics/genomics. Three to five surgical residents and two gynecologic fellows will be selected annually for this research training program through a rigorous and highly competitive process. The selection committee is composed of the program director of the training grant as well as an advisory committee. The majority of the surgical oncology trainees will be from the WUSM surgical residency. Two slots per year will be for Gynecology fellows. The long-term objective of this program is to prepare surgical/gynecology trainees, through intensive educational programs and monitored experiences in investigative research to become independent scientific investigators and to acquire faculty positions in academic departments as well as to become leading physician scientists. The success of this program is attested to by the fact that of 16 residents who have completed the program over the past 10 years, ten (62.5 percent) now hold full-time faculty positions, several with peer-reviewed funding. The Department of Surgery at WUSM has approximately 45,000 nsf of laboratory research space and over $22 million of peer-reviewed annual research support plus $2.5 million of annual clinical research support. The participating faculty have grant support in excess of $45 million. Adding to this superb environment is the Siteman Cancer Center (SCC) which is an NCI designated comprehensive cancer center. The Center treats 7,000 cancer cases annually and receives approximately $130 million of annual grant support.

Public Health Relevance

This grant provides surgical/gynecologic trainees with all of the training to become independent scientific investigators and to obtain faculty positions in academic departments. With this training, they are poised to become the future leading physician scientists in this field.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA009621-24
Application #
8279365
Study Section
Subcommittee G - Education (NCI)
Program Officer
Damico, Mark W
Project Start
1988-07-05
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
24
Fiscal Year
2012
Total Cost
$530,864
Indirect Cost
$40,226
Name
Washington University
Department
Surgery
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Tucker, Natalia S; Cyr, Amy E; Ademuyiwa, Foluso O et al. (2016) Axillary Ultrasound Accurately Excludes Clinically Significant Lymph Node Disease in Patients With Early Stage Breast Cancer. Ann Surg 264:1098-1102
Zubovic, Ema; Kodner, Ira J; Brown, Douglas et al. (2016) Ethical challenges of reconsidered informed consent in trauma. Surgery 159:1684-1688
Samson, Pamela; Robinson, Clifford G; Bradley, Jeffrey et al. (2016) The National Surgical Quality Improvement Program risk calculator does not adequately stratify risk for patients with clinical stage I non-small cell lung cancer. J Thorac Cardiovasc Surg 151:697-705.e1
Ohman, Kerri A; Hashim, Yassar M; Vangveravong, Suwanna et al. (2016) Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic. Oncotarget 7:33529-41
Kim, Samuel W; Goedegebuure, Peter; Gillanders, William E (2016) Mammaglobin-A is a target for breast cancer vaccination. Oncoimmunology 5:e1069940
Brauer, David G; Nywening, Timothy M; Jaques, David P et al. (2016) Operative Site Drainage after Hepatectomy: A Propensity Score Matched Analysis Using the American College of Surgeons NSQIP Targeted Hepatectomy Database. J Am Coll Surg 223:774-783.e2
Cyr, Amy E; Tucker, Natalia; Ademuyiwa, Foluso et al. (2016) Successful Completion of the Pilot Phase of a Randomized Controlled Trial Comparing Sentinel Lymph Node Biopsy to No Further Axillary Staging in Patients with Clinical T1-T2 N0 Breast Cancer and Normal Axillary Ultrasound. J Am Coll Surg 223:399-407
Nywening, Timothy M; Wang-Gillam, Andrea; Sanford, Dominic E et al. (2016) Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial. Lancet Oncol 17:651-62
Nwaogu, Iheoma Y; Fayanju, Oluwadamilola M; Jeffe, Donna B et al. (2015) Predictors of pathological complete response to neoadjuvant chemotherapy in stage II and III breast cancer: The impact of chemotherapeutic regimen. Mol Clin Oncol 3:1117-1122
Samson, Pamela; Patel, Aalok; Crabtree, Traves D et al. (2015) Multidisciplinary Treatment for Stage IIIA Non-Small Cell Lung Cancer: Does Institution Type Matter? Ann Thorac Surg 100:1773-9

Showing the most recent 10 out of 124 publications