The Department of Surgery at the Washington University School of Medicine in St. Louis (WUSM) requests continued funding to support a training grant in surgical oncology for surgical residents who are planning careers devoted to oncology in the specialties of general, pediatric, and thoracic surgery. Additionally, we are specifically asking for two additional dedicated positions to support trainees in gynecologic oncology. This grant will support a comprehensive educational program in laboratory research in cell and developmental biology, immunobiology, molecular biology and molecular genetics/genomics. Three to five surgical residents and two gynecologic fellows will be selected annually for this research training program through a rigorous and highly competitive process. The selection committee is composed of the program director of the training grant as well as an advisory committee. The majority of the surgical oncology trainees will be from the WUSM surgical residency. Two slots per year will be for Gynecology fellows. The long-term objective of this program is to prepare surgical/gynecology trainees, through intensive educational programs and monitored experiences in investigative research to become independent scientific investigators and to acquire faculty positions in academic departments as well as to become leading physician scientists. The success of this program is attested to by the fact that of 16 residents who have completed the program over the past 10 years, ten (62.5 percent) now hold full-time faculty positions, several with peer-reviewed funding. The Department of Surgery at WUSM has approximately 45,000 nsf of laboratory research space and over $22 million of peer-reviewed annual research support plus $2.5 million of annual clinical research support. The participating faculty have grant support in excess of $45 million. Adding to this superb environment is the Siteman Cancer Center (SCC) which is an NCI designated comprehensive cancer center. The Center treats 7,000 cancer cases annually and receives approximately $130 million of annual grant support.

Public Health Relevance

This grant provides surgical/gynecologic trainees with all of the training to become independent scientific investigators and to obtain faculty positions in academic departments. With this training, they are poised to become the future leading physician scientists in this field.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Institutional National Research Service Award (T32)
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Study Section
Subcommittee G - Education (NCI)
Program Officer
Damico, Mark W
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Washington University
Schools of Medicine
Saint Louis
United States
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Sanford, Dominic E; Sanford, Angela M; Fields, Ryan C et al. (2014) Severe nutritional risk predicts decreased long-term survival in geriatric patients undergoing pancreaticoduodenectomy for benign disease. J Am Coll Surg 219:1149-56
Hashim, Yassar M; Spitzer, Dirk; Vangveravong, Suwanna et al. (2014) Targeted pancreatic cancer therapy with the small molecule drug conjugate SW IV-134. Mol Oncol 8:956-67
Sanford, Dominic E; Olsen, Margaret A; Bommarito, Kerry M et al. (2014) Association of discharge home with home health care and 30-day readmission after pancreatectomy. J Am Coll Surg 219:875-86.e1
Zhu, Yu; Knolhoff, Brett L; Meyer, Melissa A et al. (2014) CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models. Cancer Res 74:5057-69
Fayanju, Oluwadamilola M; Kraenzle, Susan; Drake, Bettina F et al. (2014) Perceived barriers to mammography among underserved women in a Breast Health Center Outreach Program. Am J Surg 208:425-34
Rowland, Kathryn J; Diaz-Miron, Jose; Guo, Jun et al. (2014) CXCL5 is required for angiogenesis, but not structural adaptation after small bowel resection. J Pediatr Surg 49:976-80; discussion 980
Fayanju, Oluwadamilola M; Jeffe, Donna B; Elmore, Leisha et al. (2014) Breast cancer patients' experiences within and outside the safety net. J Surg Res 190:126-33
Kooby, David A; Lad, Neha L; Squires 3rd, Malcolm H et al. (2014) Value of intraoperative neck margin analysis during Whipple for pancreatic adenocarcinoma: a multicenter analysis of 1399 patients. Ann Surg 260:494-501; discussion 501-3
Hashim, Yassar M; Trinkaus, Kathryn M; Linehan, David C et al. (2014) Regional lymphadenectomy is indicated in the surgical treatment of pancreatic neuroendocrine tumors (PNETs). Ann Surg 259:197-203
Fayanju, Oluwadamilola M; Stoll, Carolyn R T; Fowler, Susan et al. (2013) Geographic and temporal trends in the management of occult primary breast cancer: a systematic review and meta-analysis. Ann Surg Oncol 20:3308-16

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