This is a competitive renewal of a training grant proposal for a program designed to train radiation biologists who will have knowledge of the molecular, cellular and tissue effects of radiation. 6 predoctoral and 4 postdoctoral trainees are requested. Training will be offered in the radiation biology and associated laboratories of the Division of Oncology Research at the University of Pennsylvania School of Medicine. The program will involve formal coursework, a lecture series and a journal club designed for our training needs, research seminars and conferences and laboratory research projects to be supervised by established investigators. The research projects will focus on various aspects of the currently funded research areas in the participating laboratories;for research projects, trainees will utilize techniques developed in modern biology to perform mechanistically-oriented studies in radiation biology/oncology. The research areas in which the 14 training preceptors are involved are broadly based in cancer research, including molecular mechanisms of carcinogenesis and mutagenesis, molecular and cellular radiation biology, radiation chemistry and biochemistry, DNA repair processes, cancer prevention and radiation oncology. It is expected that graduates of the training program will continue with their research and academic careers in radiation biology and oncology.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Institutional National Research Service Award (T32)
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Subcommittee G - Education (NCI)
Program Officer
Lim, Susan E
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University of Pennsylvania
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United States
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Ahn, Peter H; Finlay, Jarod C; Gallagher-Colombo, Shannon M et al. (2017) Lesion Oxygenation Associates with Clinical Outcomes in Premalignant and Early Stage Head and Neck Tumors Treated on a Phase 1 Trial of Photodynamic Therapy. Photodiagnosis Photodyn Ther :
Kennedy, Ann R; Maity, Amit; Sanzari, Jenine K (2016) A Review of Radiation-Induced Coagulopathy and New Findings to Support Potential Prevention Strategies and Treatments. Radiat Res 186:121-40
Grossman, Craig E; Carter, Shirron L; Czupryna, Julie et al. (2016) Fluence Rate Differences in Photodynamic Therapy Efficacy and Activation of Epidermal Growth Factor Receptor after Treatment of the Tumor-Involved Murine Thoracic Cavity. Int J Mol Sci 17:
Gallagher-Colombo, Shannon M; Miller, Joann; Cengel, Keith A et al. (2015) Erlotinib Pretreatment Improves Photodynamic Therapy of Non-Small Cell Lung Carcinoma Xenografts via Multiple Mechanisms. Cancer Res 75:3118-26
Sanzari, Jenine K; Wan, X Steven; Muehlmatt, Amy et al. (2015) Comparison of changes over time in leukocyte counts in Yucatan minipigs irradiated with simulated solar particle event-like radiation. Life Sci Space Res (Amst) 4:11-6
Sanzari, Jenine K; Billings, Paul C; Wilson, Jolaine M et al. (2015) Effect of electron radiation on vasomotor function of the left anterior descending coronary artery. Life Sci Space Res (Amst) 4:6-10
Lehman, Stacey L; Cerniglia, George J; Johannes, Gregg J et al. (2015) Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress. PLoS Genet 11:e1005212
Dorsey, Jay F; Kao, Gary D; MacArthur, Kelly M et al. (2015) Tracking viable circulating tumor cells (CTCs) in the peripheral blood of non-small cell lung cancer (NSCLC) patients undergoing definitive radiation therapy: pilot study results. Cancer 121:139-49
Gallagher-Colombo, Shannon M; Quon, Harry; Malloy, Kelly M et al. (2015) Measuring the Physiologic Properties of Oral Lesions Receiving Fractionated Photodynamic Therapy. Photochem Photobiol 91:1210-8
Sanzari, Jenine K; Diffenderfer, Eric S; Hagan, Sarah et al. (2015) Dermatopathology effects of simulated solar particle event radiation exposure in the porcine model. Life Sci Space Res (Amst) 6:21-8

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