Originally awarded in 1992, this application requests a five-year renewal of the T32 Head and Neck Training Program in Surgical Oncology at Memorial Sloan-Kettering Cancer Center (MSKCC). The mission of the Head and Neck T32 program is to train a highly selected group of talented head and neck oncologic surgeons to become high-caliber translational scientists and future academic leaders who will be positioned to advance the management of head and neck cancers. MSKCC, an NCI- designated comprehensive cancer center, provides a fertile environment rich in scientific and clinical resources that support intensive training in translational research. This T32's research training strategy integrates the following key components: (1) a committed and experienced Program Faculty spanning a wide range of scientific disciplines, with established track records of successful mentorship, (2) immersion into rigorous scientific research training in an R01-funded laboratory with appropriate guidance, (3) didactic research coursework, and (4) career development workshops. Each year, two new postdoctoral (MD or MD/PhD degrees) trainees are appointed to the Head and Neck T32 training grant for two contiguous years of dedicated research training. During this period, Head and Neck T32 trainees engage full-time in basic or translational mentored research related to head and neck cancers. Areas of potential research include genomics, molecular biology, cell biology, signal transduction, immunology, transgenic mouse modeling, chemoprevention, experimental therapeutics, and others. Research projects are matched to the particular academic interests and goals of the T32 trainee. Head and NeckT32 trainees will also enter a formal didactic program in head and neck oncology and research training, designed to supplement their individualized mentored research training. Career development workshops and seminars will help to prepare the T32 trainee for a successful competitive academic career. These workshops focus on grant writing skills, applying for career development awards, and developing the tools necessary for future independent research support. Head and Neck T32 trainees will be monitored closely and are expected to meet training milestones at designated time points. Specific expectations are delineated for trainee publications, grant submissions, national meeting presentations, and attendance at didactic conferences. Historically, a high proportion of trainees supported by the MSKCC Head and Neck T32 training program have entered academic head and neck surgical oncology and gone on to become prominent figures in the field, reflecting the effectiveness of this continuing program.

Public Health Relevance

Incidence rates for thyroid cancer and human papilloma virus (HPV)-related head and neck cancers are steadily rising, and tobacco-related head and neck cancers continue to be identified as a public health priority by the NIH. Research at the cellular, genetic, and molecular levels has revealed that cancers of the head and neck have a complex biology, distinct from other cancer types. The T32 Head and Neck Training Program in Surgical Oncology at MSKCC trains qualified clinician-scientists in head and neck cancer basic and translational research to specifically address these unique diseases.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA009685-22
Application #
8730083
Study Section
Subcommittee B - Comprehensiveness (NCI)
Program Officer
Lim, Susan E
Project Start
Project End
Budget Start
Budget End
Support Year
22
Fiscal Year
2014
Total Cost
Indirect Cost
City
New York
State
NY
Country
United States
Zip Code
10065
Chernichenko, Natalya; Linkov, Gary; Li, Pingdong et al. (2013) Oncolytic vaccinia virus therapy of salivary gland carcinoma. JAMA Otolaryngol Head Neck Surg 139:173-82
Morris, Luc G T; Kaufman, Andrew M; Gong, Yongxing et al. (2013) Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation. Nat Genet 45:253-61
Morris, Luc G T; Sikora, Andrew G; Tosteson, Tor D et al. (2013) The increasing incidence of thyroid cancer: the influence of access to care. Thyroid 23:885-91
Ho, Allen S; Kannan, Kasthuri; Roy, David M et al. (2013) The mutational landscape of adenoid cystic carcinoma. Nat Genet 45:791-8
Mohebati, Arash; Guttenplan, Joseph B; Kochhar, Amit et al. (2012) Carnosol, a constituent of Zyflamend, inhibits aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and mutagenesis. Cancer Prev Res (Phila) 5:593-602
Morris, Luc G T; Patel, Snehal G; Shah, Jatin P et al. (2011) High rates of regional failure in squamous cell carcinoma of the hard palate and maxillary alveolus. Head Neck 33:824-30
Morris, Luc G T; Sikora, Andrew G; Patel, Snehal G et al. (2011) Second primary cancers after an index head and neck cancer: subsite-specific trends in the era of human papillomavirus-associated oropharyngeal cancer. J Clin Oncol 29:739-46
Morris, Luc G T; Taylor, Barry S; Bivona, Trever G et al. (2011) Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers. Proc Natl Acad Sci U S A 108:19024-9
Kim, Alyn J; Liu, Jeffrey C; Ganly, Ian et al. (2011) Minimally invasive video-assisted thyroidectomy 2.0: expanded indications in a tertiary care cancer center. Head Neck 33:1557-60
Jethanamest, Daniel; Vila, Peter M; Sikora, Andrew G et al. (2011) Predictors of survival in mucosal melanoma of the head and neck. Ann Surg Oncol 18:2748-56

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