The education of new investigators is essential to our progress in the prevention, detection, diagnosis, and treatment of cancer. This application seeks renewal of funding for the Tumor Biology Interdisciplinary training program at Georgetown University that has been funded by NCI since 1996. Our program has become the premier graduate and postdoctoral training program at Georgetown University Medical Center (GUMC). Its major focus is to provide predoctoral and postdoctoral trainees with lifelong multidisciplinary skills that will enable them to make significant contributions in the eradication of human cancer and to interact productively in their future with clinicians and clinical research programs. The structure of the program is integrated into the strengths of the Lombardi Comprehensive Cancer Center (LCCC), an NCI-designated comprehensive cancer center at GUMC. LCCC provides the platform for the program, stimulating interdisciplinary collaborations, offering a forum for communication and discussion of research and extensive core facilities to support research. State-of-the-art cancer research training is available in the laboratories of the participating faculty, while formal courses, seminars, journal clubs, and special interest group meetings contribute to a distinctly interdisciplinary educational experience for pre- and postdoctoral fellows. Our faculty have developed more than a dozen cancer-specific courses for this training program, and continue to create more. Significant exposure to clinical concepts is through courses, involvement in weekly clinical conferences, and seminars that focus on translational cancer research. We have received many outstanding applicants, and we have filled all slots annually and many of our past trainees have gone on to prestigious faculty positions. Recruitment of under represented minorities (URM) has been successful and several of our URM trainees are now in faculty positions in academia. The continued support of this Program will allow us to maintain our mission of focused, high quality mentorship for initiation of careers of successful new investigators, by further improving our excellent track record of academic productivity in training translational cancer biologists.
(Seeinstructions): The education of new investigators is essential to our progress in the prevention, detection, diagnosis, and treatment of cancer. This training program is to provide predoctoral and postdoctoral trainees with lifelong multidisciplinary skills that will enable them to make significant contributions in the eradication of human cancer and to interact productively in their future in a clinical cancer research environment.
|Berens, E B; Sharif, G M; Schmidt, M O et al. (2016) Keratin-associated protein 5-5 controls cytoskeletal function and cancer cell vascular invasion. Oncogene :|
|Heckler, Mary M; Zeleke, Tizita Zewde; Divekar, Shailaja D et al. (2016) Antimitotic activity of DY131 and the estrogen-related receptor beta 2 (ERRÎ²2) splice variant in breast cancer. Oncotarget :|
|Croglio, Michael P; Haake, Jefferson M; Ryan, Colin P et al. (2016) Analogs of the novel phytohormone, strigolactone, trigger apoptosis and synergize with PARP inhibitors by inducing DNA damage and inhibiting DNA repair. Oncotarget 7:13984-4001|
|Nomura, Sarah J O; Dash, Chiranjeev; Rosenberg, Lynn et al. (2016) Is adherence to diet, physical activity, and body weight cancer prevention recommendations associated with colorectal cancer incidence in African American women? Cancer Causes Control 27:869-79|
|Divekar, Shailaja D; Tiek, Deanna M; Fernandez, Aileen et al. (2016) Estrogen-related receptor Î² (ERRÎ²) - renaissance receptor or receptor renaissance? Nucl Recept Signal 14:e002|
|(2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12:1-222|
|Zhang, Y-W; Nasto, R E; Varghese, R et al. (2016) Acquisition of estrogen independence induces TOB1-related mechanisms supporting breast cancer cell proliferation. Oncogene 35:1643-56|
|Zhu, Eric F; Gai, Shuning A; Opel, Cary F et al. (2015) Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2. Cancer Cell 27:489-501|
|Parodi, Daniela A; Greenfield, Morgan; Evans, Claire et al. (2015) Alteration of mammary gland development and gene expression by in utero exposure to arsenic. Reprod Toxicol 54:66-75|
|Adhikari, Sanjay; Chetram, Mahandranauth A; Woodrick, Jordan et al. (2015) Germ line variants of human N-methylpurine DNA glycosylase show impaired DNA repair activity and facilitate 1,N6-ethenoadenine-induced mutations. J Biol Chem 290:4966-80|
Showing the most recent 10 out of 115 publications