The education of the next generation of cancer researchers is essential to our progress in the prevention, detection, diagnosis, and treatment of cancer. This application seeks renewal of funding for the Tumor Biology Interdisciplinary Training Program that has been funded by NCI since 1996. Our program is the premier graduate and postdoctoral training program at Georgetown University Medical Center (GUMC). Its major focus is to provide pre-doctoral and postdoctoral trainees with lifelong interdisciplinar skills that will enable them to make significant contributions in the eradication of human cancer and to interact productively in their future with clinical cancer research programs. The program is structurally integrated with the strengths of the NCI- designated, Lombardi Comprehensive Cancer Center (LCCC) at GUMC. LCCC provides a stimulating environment for the program with interdisciplinary collaborations, extensive core facilities to support research, and a forum fr communication and discussion of research. State-of-the-art cancer research training is available in the laboratories of the participating faculty. Courses, workshops, seminars, journal clubs, research fairs, and special interest group meetings contribute to the distinctly interdisciplinary training for pre- and postdoctoral fellows. Our faculty has developed more than a dozen cancer-related courses that integrate core concepts of cancer biology, clinical disease, bioinformatics as well as emerging research technologies, and health disparities. Exposure to clinical concepts is emphasized through courses, involvement in weekly clinical conferences, and seminars that focus on translational cancer research. The program has continuously attracted outstanding applicants and thus all available slots are filled annually. Many of our past trainees have gone on to prestigious research positions. Our program emphasizes recruitment of underrepresented minorities (URM) and a significant number of our URM trainees are now in faculty positions in academia. The continued support of this Program will allow us to maintain our mission to train the next generation of researchers that contribute to the eradication of cancer.

Public Health Relevance

The education of the next generation of cancer researchers is essential to our progress in the prevention, detection, diagnosis, and treatment of cancer. This application seeks renewal of funding for the Tumor Biology Interdisciplinary Training Program at Georgetown University Medical Center (GUMC). Its major focus is to provide pre-doctoral and postdoctoral trainees with lifelong interdisciplinary skills that will enable them to make significnt contributions in the eradication of human cancer and to interact productively in their future with clinical cancer research programs.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
2T32CA009686-18
Application #
8664063
Study Section
Subcommittee G - Education (NCI)
Program Officer
Damico, Mark W
Project Start
1996-07-01
Project End
2019-05-31
Budget Start
2014-06-10
Budget End
2015-05-31
Support Year
18
Fiscal Year
2014
Total Cost
$471,850
Indirect Cost
$33,604
Name
Georgetown University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057
Berens, E B; Sharif, G M; Schmidt, M O et al. (2016) Keratin-associated protein 5-5 controls cytoskeletal function and cancer cell vascular invasion. Oncogene :
Heckler, Mary M; Zeleke, Tizita Zewde; Divekar, Shailaja D et al. (2016) Antimitotic activity of DY131 and the estrogen-related receptor beta 2 (ERRβ2) splice variant in breast cancer. Oncotarget :
Croglio, Michael P; Haake, Jefferson M; Ryan, Colin P et al. (2016) Analogs of the novel phytohormone, strigolactone, trigger apoptosis and synergize with PARP inhibitors by inducing DNA damage and inhibiting DNA repair. Oncotarget 7:13984-4001
Nomura, Sarah J O; Dash, Chiranjeev; Rosenberg, Lynn et al. (2016) Is adherence to diet, physical activity, and body weight cancer prevention recommendations associated with colorectal cancer incidence in African American women? Cancer Causes Control 27:869-79
Divekar, Shailaja D; Tiek, Deanna M; Fernandez, Aileen et al. (2016) Estrogen-related receptor β (ERRβ) - renaissance receptor or receptor renaissance? Nucl Recept Signal 14:e002
(2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12:1-222
Zhang, Y-W; Nasto, R E; Varghese, R et al. (2016) Acquisition of estrogen independence induces TOB1-related mechanisms supporting breast cancer cell proliferation. Oncogene 35:1643-56
Zhu, Eric F; Gai, Shuning A; Opel, Cary F et al. (2015) Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2. Cancer Cell 27:489-501
Parodi, Daniela A; Greenfield, Morgan; Evans, Claire et al. (2015) Alteration of mammary gland development and gene expression by in utero exposure to arsenic. Reprod Toxicol 54:66-75
Adhikari, Sanjay; Chetram, Mahandranauth A; Woodrick, Jordan et al. (2015) Germ line variants of human N-methylpurine DNA glycosylase show impaired DNA repair activity and facilitate 1,N6-ethenoadenine-induced mutations. J Biol Chem 290:4966-80

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