): The Training Program in Cancer Biology is a program for pre- and postdoctoral trainees designed to produce investigators who will focus on biological and chemical issues specifically related to the cancer problem during their research careers. Our program will impart to trainees a clear understanding of the relationships between the basic problems and clinical issue of human cancer. The Program is anchored in the Department of Cancer Biology of the Wake Forest University Cancer Center; all faculty are either primary Cancer Biology Department members, or are cross-appointed to Cancer Biology. The cross appointees come from the Departments of Chemistry, Biochemistry, Pathology, Radiation oncology, and Hematology/Oncology. Trainees will include predoctoral Ph.D. candidates, postdoctoral Ph.D.'s and M.D.'s desiring to supplement their clinical training with training in cancer research. All predoctoral trainees will be candidates for a Ph.D. degree in Cancer Biology, a degree candidacy program of Wake Forest University begun in the fall semester, 1997. Pre- and postdoctoral traineeships will combine research, seminar/symposia participation, plus didactic coursework taught by Department faculty covering DNA damage and repair, cancer cell biology, signal transduction, cell cycle control, tumor immunology, gene therapy and an overview of clinical and epidemiologic issues in human cancer. Research will supervised by Departmental faculty preceptors; specific assignments will be made by the Program executive committee in consultation with an oversight board. Key features of the Training Program include an extensive mentoring and evaluation process and a faculty with active research programs that mesh clinical and basic science. This training program will address the goals of the National Cancer Institute in three ways: (1) it will produce investigators equipped to focus on the cancer problem in their research careers; (2) it will provide education spanning the chemical- biological interface; (3) it will emphasize the linkage between basic science and the clinical problems of human cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
1T32CA079448-01A1
Application #
6023963
Study Section
Subcommittee G - Education (NCI)
Program Officer
Eckstein, David J
Project Start
2000-03-15
Project End
2005-02-28
Budget Start
2000-03-15
Budget End
2001-02-28
Support Year
1
Fiscal Year
2000
Total Cost
$146,443
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Biology
Type
Schools of Medicine
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
Blischak, Paul D; Chifman, Julia; Wolfe, Andrea D et al. (2018) HyDe: A Python Package for Genome-Scale Hybridization Detection. Syst Biol 67:821-829
Swanner, Jessica; Singh, Ravi (2018) Synthesis, Purification, Characterization, and Imaging of Cy3-Functionalized Fluorescent Silver Nanoparticles in 2D and 3D Tumor Models. Methods Mol Biol 1790:209-218
Chmielewski, Jeffrey P; Bowlby, Sarah C; Wheeler, Frances B et al. (2018) CD38 Inhibits Prostate Cancer Metabolism and Proliferation by Reducing Cellular NAD+ Pools. Mol Cancer Res 16:1687-1700
Sirkisoon, Sherona R; Carpenter, Richard L; Rimkus, Tadas et al. (2018) Interaction between STAT3 and GLI1/tGLI1 oncogenic transcription factors promotes the aggressiveness of triple-negative breast cancers and HER2-enriched breast cancer. Oncogene 37:2502-2514
Rimkus, Tadas K; Carpenter, Richard L; Sirkisoon, Sherona et al. (2018) Truncated Glioma-Associated Oncogene Homolog 1 (tGLI1) Mediates Mesenchymal Glioblastoma via Transcriptional Activation of CD44. Cancer Res 78:2589-2600
Chifman, Julia; Arat, Seda; Deng, Zhiyong et al. (2017) Activated Oncogenic Pathway Modifies Iron Network in Breast Epithelial Cells: A Dynamic Modeling Perspective. PLoS Comput Biol 13:e1005352
Nickkholgh, Bita; Sittadjody, Sivanandane; Rothberg, Michael B et al. (2017) Beta-catenin represses protein kinase D1 gene expression by non-canonical pathway through MYC/MAX transcription complex in prostate cancer. Oncotarget 8:78811-78824
Carpenter, Richard L; Sirkisoon, Sherona; Zhu, Dongqin et al. (2017) Combined inhibition of AKT and HSF1 suppresses breast cancer stem cells and tumor growth. Oncotarget 8:73947-73963
Alexander, Peter M; Caudell, David L; Kucera, Gregory L et al. (2017) The novel phospholipid mimetic KPC34 is highly active against preclinical models of Philadelphia chromosome positive acute lymphoblastic leukemia. PLoS One 12:e0179798
Eldridge, Brittany N; Xing, Fei; Fahrenholtz, Cale D et al. (2017) Evaluation of multiwalled carbon nanotube cytotoxicity in cultures of human brain microvascular endothelial cells grown on plastic or basement membrane. Toxicol In Vitro 41:223-231

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