Our aim is to train young scientists to design and conduct research on significant problems in cancer by combining information and approaches from different scientific disciplines, including basic cellular and molecular biology, epidemiology clinical trials and studies, and behavioral-social sciences. The rationale behind this program is to produce researchers who can excel in the increasingly complex and specialized environments required for future cancer research. The IDTG is a highly competitive and demanding training program. Trainees work closely with two mentors who provide distinct, complementary areas of expertise (for example, by studying basic molecular and cellular mechanisms of neoplasia in combination with epidemiological analyses of related risk factors;or by participating in clinical research studies while studying behavioral or environmental factors that influence therapeutic outcomes). Our trainee projects transcend the traditional boundaries separating the molecular and cellular, clinical, epidemiologic and social cancer sciences. As a result, the IDTG and Program differ fundamentally in focus, goals and training plans from other pre- and post-Doctoral training programs in the Seattle biomedical research community. The Interdisciplinary Training Grant in Cancer Research supports two separate types of interdisciplinary trainees. The first are dual-mentor PhD candidates and postdoctoral fellows, who work within two separate research groups to study a common problem in cancer using unique, and yet complementary research disciplines. The second are graduate students who are enrolled in a dual-degree program that allows Ph.D. students in the Molecular and Cellular Biology (MCB) graduate program to earn a concurrent Masters of Science degree in Epidemiology. Trainees in either type of track are supported by this training grant as part of a broad initiative in Seattle to create a scientific culture where interdisciplinary cancer research and training is encouraged and fostered. Three separate institutions (The Fred Hutchinson Cancer Research Center, the University of Washington, and the Institute for Systems Biology) have served as research sites for IDTG trainees and their mentors. The IDTG faculty mentors each have primary appointments at one of those three institutions, and the majority have additional cross-institutional affiliate appointments within the UW graduate school and/or in the Seattle Cancer Consortium. We have created an environment across all these institutions where graduate students and postdoctoral fellows can become conversant in the goals, assumptions, logic, methods, and vocabulary of multiple research disciplines.

Public Health Relevance

The IDTG is focused specifically on training graduate students and post-doctoral fellows in two or more cancer- related disciplines. It specifically supports the training of 'dual-mentored'graduate students and postdocs, who work on a research problem in cancer with two mentors who collaboratively supervise and direct complementary approaches to studying that problem, using tools and approaches from two separate research disciplines. The IDTG also supports training for students who are enrolled in a dual-degree program in Seattle that leads to a Masters degree in epidemiology ('MS Epi') and a PhD in Molecular and Cellular Biology (MCB). Over the past ten years, the IDTG has provided support for 54 past trainees and 9 current trainees. Almost all of the past trainees are still working in cancer-related research and/or patient care: 10% as academic faculty, another 25% as staff scientists, 25% in biotechnology and industry, and the remainder either as cancer physicians or as continuing graduate or postdoctoral fellows.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
2T32CA080416-16A1
Application #
8793698
Study Section
Subcommittee G - Education (NCI)
Program Officer
Lim, Susan E
Project Start
1998-08-11
Project End
2019-08-31
Budget Start
2014-09-16
Budget End
2015-08-31
Support Year
16
Fiscal Year
2014
Total Cost
$388,267
Indirect Cost
$32,583
Name
University of Washington
Department
Biochemistry
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Morris, S M; Carter, K T; Baek, J Y et al. (2015) TGF-? signaling alters the pattern of liver tumorigenesis induced by Pten inactivation. Oncogene 34:3273-82
Yu, M; Trobridge, P; Wang, Y et al. (2014) Inactivation of TGF-* signaling and loss of PTEN cooperate to induce colon cancer in vivo. Oncogene 33:1538-47
Slyker, Jennifer; Farquhar, Carey; Atkinson, Claire et al. (2014) Compartmentalized cytomegalovirus replication and transmission in the setting of maternal HIV-1 infection. Clin Infect Dis 58:564-72
London, Nitobe; Biggins, Sue (2014) Signalling dynamics in the spindle checkpoint response. Nat Rev Mol Cell Biol 15:736-47
Yao, Zizhen; Macquarrie, Kyle L; Fong, Abraham P et al. (2014) Discriminative motif analysis of high-throughput dataset. Bioinformatics 30:775-83
Lauper, Julia M; Monnat Jr, Raymond J (2014) Diabetes mellitus and cancer in Werner syndrome. Acta Diabetol 51:159-61
Jordan-Williams, Kimberly L; Ruddell, Alanna (2014) Culturing purifies murine lymph node lymphatic endothelium. Lymphat Res Biol 12:144-9
Correia, Bruno E; Bates, John T; Loomis, Rebecca J et al. (2014) Proof of principle for epitope-focused vaccine design. Nature 507:201-6
London, Nitobe; Biggins, Sue (2014) Mad1 kinetochore recruitment by Mps1-mediated phosphorylation of Bub1 signals the spindle checkpoint. Genes Dev 28:140-52
Vojtech, Lucia; Woo, Sangsoon; Hughes, Sean et al. (2014) Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions. Nucleic Acids Res 42:7290-304

Showing the most recent 10 out of 87 publications