This application requests continuing support for post-doctoral training in surgical oncology research for four fellows. The Vanderbilt Department of Surgery has had a continuing commitment to mentored research for both resident research fellows and junior surgical oncology research faculty. Given the rapid pace and complexity of both basic and clinical research, it is imperative to provide trainees with the requisite armamentarium of investigative skills during post-doctoral training. The establishment of both research proficiency and a pattern of mentored training are critical for the promotion of successful academic career pathways. Importantly, we have configured a multidisciplinary training program to allow development of investigators along basic, patient-oriented, clinical research or bioinformatics research tracks. All four of these research paradigms are considered crucial to the success of broad-based cancer-related investigation. The objective of this program is to prepare surgical residents and post-doctoral fellows for investigative careers in research fields related to surgical oncology. Fellows commit at least two years to intensive training in basic, translational or clinical research through a mentored training environment necessary for the development of experience and proficiency in investigative techniques and reasoning. For those interested in basic science research training, opportunities for mentored investigation are available in the laboratories of scientists with broad interests in cancer biology. In addition to bench research training, fellows in the basic research track will participate in didactic course work as determined by the individual advisory committees. Pursuit of a basic science PhD program is available. Fellows interested in patient-oriented research training may pursue a Masters of Science in Clinical Investigation (MSCI). The MSCI program combines broad didactic coursework with a mentored research experience focused on patient related material or therapeutic intervention. Finally, those interested in epidemiological or outcomes research may pursue a Masters of Public Health (MPH). The MPH program combines didactic coursework in clinical epidemiology with a mentored clinical research project. Finally, the Masters in Bioinformatics program provides training for those interested in the expanding field of bioinformatics as it applies to both basic and clinical research. These four training tracks allow fellows to pursue the pathways best suited to their career objectives.

Public Health Relevance

Surgeons remain at the forefront of the care for patients with cancer. The clinical experience of surgeons gives them a particular perspective on cancer. There is a need for research expertise among surgeons and those interested in surgical oncology so that these individuals are fully prepared to tackle the important future research needs in basic cancer biology, translational cancer research and cancer epidemiology.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA106183-13
Application #
9116100
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Perkins, Susan N
Project Start
2004-09-30
Project End
2020-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
13
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
079917897
City
Nashville
State
TN
Country
United States
Zip Code
37232
Schlegel, Cameron; Weis, Victoria G; Knowles, Byron C et al. (2018) Apical Membrane Alterations in Non-intestinal Organs in Microvillus Inclusion Disease. Dig Dis Sci 63:356-365
Petersen, Christine P; Meyer, Anne R; De Salvo, Carlo et al. (2018) A signalling cascade of IL-33 to IL-13 regulates metaplasia in the mouse stomach. Gut 67:805-817
Engevik, Amy C; Kaji, Izumi; Engevik, Melinda A et al. (2018) Loss of MYO5B Leads to Reductions in Na+ Absorption With Maintenance of CFTR-Dependent Cl- Secretion in Enterocytes. Gastroenterology 155:1883-1897.e10
Krasnick, Bradley A; Jin, Linda X; Davidson 4th, Jesse T et al. (2018) Adjuvant therapy is associated with improved survival after curative resection for hilar cholangiocarcinoma: A multi-institution analysis from the U.S. extrahepatic biliary malignancy consortium. J Surg Oncol 117:363-371
Schlegel, Cameron; Lapierre, Lynne A; Weis, Victoria G et al. (2018) Reversible deficits in apical transporter trafficking associated with deficiency in diacylglycerol acyltransferase. Traffic 19:879-892
Ethun, Cecilia G; Lopez-Aguiar, Alexandra G; Anderson, Douglas J et al. (2018) Transplantation Versus Resection for Hilar Cholangiocarcinoma: An Argument for Shifting Treatment Paradigms for Resectable Disease. Ann Surg 267:797-805
Tyson 2nd, Mark Douglas; Koyama, Tatsuki; Lee, Dan et al. (2018) Effect of Prostate Cancer Severity on Functional Outcomes After Localized Treatment: Comparative Effectiveness Analysis of Surgery and Radiation Study Results. Eur Urol 74:26-33
Engevik, Amy Christine; Goldenring, James R (2018) Trafficking Ion Transporters to the Apical Membrane of Polarized Intestinal Enterocytes. Cold Spring Harb Perspect Biol 10:
Barocas, Daniel A; Alvarez, JoAnn; Resnick, Matthew J et al. (2017) Association Between Radiation Therapy, Surgery, or Observation for Localized Prostate Cancer and Patient-Reported Outcomes After 3 Years. JAMA 317:1126-1140
Tyson, Mark D; Alvarez, JoAnn; Koyama, Tatsuki et al. (2017) Racial Variation in Patient-Reported Outcomes Following Treatment for Localized Prostate Cancer: Results from the CEASAR Study. Eur Urol 72:307-314

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