The objective of this first renewal of the Integrated Biological Systems Training in Oncology (IBSTO) program is to continue to prepare predoctoral students and postdoctoral fellows for careers in cancer research with comprehensive training in basic and translational research. IBSTO training focuses on basic cellular processes and mechanisms that are shared between cell biology and developmental biology that are critical to understanding how cells become tumorigenic and on how to translate this basic research knowledge to the diagnosis, treatment and prevention of cancer. The IBSTO program takes place in an active and growing Medical Center environment with state-of-the-art facilities, a vibrant NCI-designated comprehensive cancer center, top-ranked basic science departments, an Interdisciplinary Graduate Program in Biomedical Sciences, and an active Office of Postdoctoral Affairs. The Program Director has a strong record of basic cancer research and administrative experience. In our first four years we have already recruited 22 outstanding predoctoral and postdoctoral trainees that have been very productive. Trainees have been placed with experienced, well-funded, productive preceptors in an interactive research environment with extensive resources. The three broad areas of experience of our preceptors are in cell biology, developmental biology/genetics and medicine. Each trainee has mentors from each group to provide unique and valuable perspectives to enhance their cancer-related research training. The goals of our training program are to provide proactive mentoring and oversight, provide cross-discipline education and research, provide training in cutting edge methodology, develop useful academic skills, foster interactions with faculty and other trainees, provide exposure to current cancer research discoveries, and provide exposure to clinical cancer treatment and translational research. In this renewal we have strengthened our clinical/translational component with the addition of an Associate Director and new preceptors who focus on translational research and new required clinical training experience in oncology. We strongly believe that integrating basic science research training in cell biology, developmental biology and genetics with translational and clinical experience allows a better understanding of the multiple lesions in cellular processes that define cancer, which is critical t diagnosing, treating and eventually preventing of this disease.

Public Health Relevance

The Integrated Biological Systems Training in Oncology (IBSTO) program prepares predoctoral students and postdoctoral fellows for careers in cancer research with comprehensive training in basic and translational research. The IBSTO program takes place in an active Medical Center environment with state-of-the-art facilities, experienced preceptors in an interactive education and research environment with extensive resources and insitutional commitment. The IBSTO program provides our productive trainees unique mentoring, useful academic skills, interactions with faculty and other trainees, exposure to current cancer research discoveries and exposure to clinical cancer treatment and translational research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA119925-07
Application #
8697020
Study Section
Subcommittee B - Comprehensiveness (NCI)
Program Officer
Damico, Mark W
Project Start
2006-04-01
Project End
2018-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
7
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
City
Nashville
State
TN
Country
United States
Zip Code
37212
Arnette, Christopher; Frye, Keyada; Kaverina, Irina (2016) Microtubule and Actin Interplay Drive Intracellular c-Src Trafficking. PLoS One 11:e0148996
Thomas, L R; Foshage, A M; Weissmiller, A M et al. (2016) Interaction of MYC with host cell factor-1 is mediated by the evolutionarily conserved Myc box IV motif. Oncogene 35:3613-8
Grabowska, Magdalena M; Kelly, Stephen M; Reese, Amy L et al. (2016) Nfib Regulates Transcriptional Networks That Control the Development of Prostatic Hyperplasia. Endocrinology 157:1094-109
Broadus, Matthew R; Chen, Tony W; Neitzel, Leif R et al. (2016) Identification of a Paralog-Specific Notch1 Intracellular Domain Degron. Cell Rep 15:1920-9
Broadus, Matthew R; Yew, P Renee; Hann, Stephen R et al. (2015) Small-molecule high-throughput screening utilizing Xenopus egg extract. Methods Mol Biol 1263:63-73
Willet, Alaina H; McDonald, Nathan A; Bohnert, K Adam et al. (2015) The F-BAR Cdc15 promotes contractile ring formation through the direct recruitment of the formin Cdc12. J Cell Biol 208:391-9
Golson, Maria L; Dunn, Jennifer C; Maulis, Matthew F et al. (2015) Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion. Diabetes 64:3829-38
Bates, Andreia L; Pickup, Michael W; Hallett, Miranda A et al. (2015) Stromal matrix metalloproteinase 2 regulates collagen expression and promotes the outgrowth of experimental metastases. J Pathol 235:773-83
Kondo, Jumpei; Powell, Anne E; Wang, Yang et al. (2015) LRIG1 Regulates Ontogeny of Smooth Muscle-Derived Subsets of Interstitial Cells of Cajal in Mice. Gastroenterology 149:407-19.e8
Liu, Yan; Hawkins, Oriana E; Vilgelm, Anna E et al. (2015) Combining an Aurora Kinase Inhibitor and a Death Receptor Ligand/Agonist Antibody Triggers Apoptosis in Melanoma Cells and Prevents Tumor Growth in Preclinical Mouse Models. Clin Cancer Res 21:5338-48

Showing the most recent 10 out of 65 publications