This predoctoral and postdoctoral training program emphasizes bench to bedside research encompassing state-of-the-art areas of cancer research. Along with training in the fundamentals of cancer research and sound scientific theory, students and postdoctoral fellows will be trained in many fundamental areas of cancer research including, drug discovery using high throughput chemical and genetic screens to define cellular networks, signal transduction pathways, DNA damage and repair responses, and nanomedicine-targeted therapeutic drug delivery using cell and animal molecular imaging. The problem of cancer in the 21st century remains a national priority, and as such, offers a substantive long-term career opportunity for the training of predoctoral and postdoctoral students. The goals of our training program are to (a) train top-quality scientists capable of conducting independent cancer research;(b) foster the intellectual, technical, and communication skills required to succeed in the academic or industrial arenas of today and in the future;and (c) provide an understanding of the basic, public health, and clinical problems of human cancer. The ability of this training grant to bridge an existing outstanding foundation of Faculty in Basic Science with our Cancer Biology and Therapy Programs in the Harold Simmons NCI Designated Cancer Center, distinguishes it from a standardized general graduate and post-graduate educational program. We have 43 committed Faculty Trainers representing 24 different Departments and Centers at UT Southwestern. We have assembled a dedicated group of Steering Committee members, along with Administrative Support and both intellectual and financial support from the Director of the Cancer Center. We have an integrated plan for the proposed Cancer Training Program for both predoctoral and postdoctoral trainees that details all key steps in cancer education and training, including biomedical ethics, the responsible conduct of science, biostatistics, bioinformatics, and data sharing. We have a program specific plan for recruiting and retaining a geographically broad range of predoctoral and postdoctoral applicants as well as underrepresented diversity trainees. We have expanded and implemented our cancer didactic and journal oriented courses, both basic and translational. Our domestic eligible predoctoral and postdoctoral applicant pool has almost doubled during the last 4 years and our Faculty Trainer pool has increased by approximately 50%.
This T32 renewal application describes a comprehensive recruitment, training and retention program that combines a strong basic science curriculum with a strong translational cancer focus that distinguishes it from other training programs. Our goals are to train top-quality scientists capable of conducting independent cancer research;foster the intellectual, technical and communication skills required to succeed in the academic or industrial arenas of today and in the future;and to provide an understanding of the basic, public health, and clinical problems of human cancer. During our first review period 50% of all appointees to this T32 have been diversity trainees, our Cancer Biology Program has been fully approved by the Texas Higher Educational Board, UT Southwestern has become a NCI Designated Cancer Center, we have increased our cancer related funding almost 5-fold, and we have increased our student and postdoctoral T32 eligible trainees over 3-fold.
|Alcantara Llaguno, Sheila R; Parada, Luis F (2016) Cell of origin of glioma: biological and clinical implications. Br J Cancer 115:1445-1450|
|Sanchez, Angelica; Amatruda, James F (2016) Zebrafish Germ Cell Tumors. Adv Exp Med Biol 916:479-94|
|Patidar, Praveen L; Motea, Edward A; Fattah, Farjana J et al. (2016) The Kub5-Hera/RPRD1B interactome: a novel role in preserving genetic stability by regulating DNA mismatch repair. Nucleic Acids Res 44:1718-31|
|Robin, JÃ©rÃ´me D; Ludlow, Andrew T; LaRanger, Ryan et al. (2016) Comparison of DNA Quantification Methods for Next Generation Sequencing. Sci Rep 6:24067|
|Mor, Amir; White, Alexander; Zhang, Ke et al. (2016) Influenza Virus mRNA Trafficking Through Host Nuclear Speckles. Nat Microbiol 2016:|
|Tran, Tram Anh; Leong, Hon Sing; Pavia-Jimenez, Andrea et al. (2016) Fibroblast Growth Factor Receptor-Dependent and -Independent Paracrine Signaling by Sunitinib-Resistant Renal Cell Carcinoma. Mol Cell Biol 36:1836-55|
|Tang, Ke-Jing; Constanzo, Jerfiz D; Venkateswaran, Niranjan et al. (2016) Focal Adhesion Kinase Regulates the DNA Damage Response and Its Inhibition Radiosensitizes Mutant KRAS Lung Cancer. Clin Cancer Res 22:5851-5863|
|Kim, S B; Bozeman, R G; Kaisani, A et al. (2016) Radiation promotes colorectal cancer initiation and progression by inducing senescence-associated inflammatory responses. Oncogene 35:3365-75|
|Thorne, Curtis A; Wichaidit, Chonlarat; Coster, Adam D et al. (2015) GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors. Nat Chem Biol 11:58-63|
|Camacho, C V; Todorova, P K; Hardebeck, M C et al. (2015) DNA double-strand breaks cooperate with loss of Ink4 and Arf tumor suppressors to generate glioblastomas with frequent Met amplification. Oncogene 34:1064-72|
Showing the most recent 10 out of 43 publications