The UT Southwestern Physician Scientist Oncology Training Program will provide fellows and residents who have finished their clinical training in oncology the opportunity and protected time to develop the technical and Intellectual skills for a successful laboratory based oncology research program. The program will accomplish this by providing highly Individualized mentorship, the opportunity to train in the research laboratories of one of our internationally renowned faculty and up to three years of stipend support during the years of their research training. Specifically, the goals of the program are to support physicians who have finished their subspecialty clinical training in oncology and train them in lab-based translational oncology research, by providing (a) training in the laboratory skills necessary to investigate the pathogenesis and biology of cancer, (b) a rigorous mentoring and didactic program in the biology of cancer, biostatistics, ethics, and regulatory issues, (c) and training in the investigation of basic cancer questions which are clinically relevant, and in the translation of clinical observations into hypothesis based laboratory questions. Trainees will be mentored primarily by scientists who participate in one of the five programs in the Cancer Center, but will also have secondary, clinical research resource faculty mentors to ensure that the trainee develops the clinical skills and expertise necessary to succeed in a multi-disciplinary approach to the study of clinically relevant cancer questions. Unique opportunities of the program include the outstanding faculty of Cancer Biology Training Program for pre-and post doctoral PhDs within the Graduate School of Biological Sciences, a Specialized Program of Research Excellence in Lung Cancer, and a Program Project Grant on the Concerted Chemical, Biophysical and Molecular Biological Attack of Intracellular Pathways Relevant to Human Cancer. 20 laboratory mentors representing 15 different Departments and Centers are committed to this program, as are 11 clinical resource mentors. A Steering Committee consisting of 7 senior physician and scientist leaders in the Cancer Center will provide oversight and direction, and administrative support will be provided by the Cancer Center.

Public Health Relevance

The goal of this program is to produce top-quality physician scientists who are committed to an academic career in patient-related basic and/or translational oncology research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA136515-03
Application #
8119404
Study Section
Subcommittee G - Education (NCI)
Program Officer
Lim, Susan E
Project Start
2009-09-01
Project End
2014-08-31
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
3
Fiscal Year
2011
Total Cost
$253,900
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
Patil, Rohit V; Woldu, Solomon L; Lucas, Elena et al. (2017) Metastatic Melanoma to the Bladder: Case Report and Review of the Literature. Urol Case Rep 11:33-36
Aydin, Ahmet Murat; Woldu, Solomon L; Hutchinson, Ryan C et al. (2017) Spotlight on atezolizumab and its potential in the treatment of advanced urothelial bladder cancer. Onco Targets Ther 10:1487-1502
Clinton, Timothy N; Bagrodia, Aditya; Lotan, Yair et al. (2017) Tissue-based biomarkers in prostate cancer. Expert Rev Precis Med Drug Dev 2:249-260
Woldu, Solomon L; Bagrodia, Aditya; Lotan, Yair (2017) Guideline of guidelines: non-muscle-invasive bladder cancer. BJU Int 119:371-380
Krabbe, Laura-Maria; Woldu, Solomon L; Shariat, Shahrokh F et al. (2016) Improving diagnostic molecular tests to monitor urothelial carcinoma recurrence. Expert Rev Mol Diagn 16:1189-1199
Dietrich, Martin Frederik; Yan, Shirley Xiao; Schiller, Joan Hoff (2015) Response to Crizotinib/Erlotinib Combination in a Patient with a Primary EGFR-Mutant Adenocarcinoma and a Primary c-met-Amplified Adenocarcinoma of the Lung. J Thorac Oncol 10:e23-5
Kirane, Amanda; Ludwig, Kathleen F; Sorrelle, Noah et al. (2015) Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis. Cancer Res 75:3699-705
Singel, Stina M; Batten, Kimberly; Cornelius, Crystal et al. (2014) Receptor-interacting protein kinase 2 promotes triple-negative breast cancer cell migration and invasion via activation of nuclear factor-kappaB and c-Jun N-terminal kinase pathways. Breast Cancer Res 16:R28
Dietrich, Martin F; Cavuoti, Dominick; Landay, Michael et al. (2014) Histological Regression of Giant Cell Tumor of Bone Following RANK Ligand Inhibition. J Investig Med High Impact Case Rep 2:2324709614560216
Singel, Stina Mui; Cornelius, Crystal; Batten, Kimberly et al. (2013) A targeted RNAi screen of the breast cancer genome identifies KIF14 and TLN1 as genes that modulate docetaxel chemosensitivity in triple-negative breast cancer. Clin Cancer Res 19:2061-70

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