The primary goal of the Cancer Gene Discovery and Cancer Biology Postdoctoral Research Training Program at Cold Spring Harbor Laboratory (CSHL) is to prepare the next generation of cancer biologists to pursue independent research that integrates cancer gene discovery with functional biology in order to facilitate the development of novel cancer therapeutic, diagnostic and/or preventive strategies. Features of the three year research training program include a combination of: mandatory and elective didactic components;structured career development guidance;monthly research seminars;graduate and community based teaching opportunities;and research experiences in laboratories affiliated with the CSHL National Cancer Institute (NCI) designated Cancer Center. Postdoctoral trainees benefit from a small faculty to trainee ratio in nineteen potential preceptor laboratories, an on-site internationally renowned Scientific Meetings and Courses program, and newly expanded state-of-the-art cancer research facilities. Cancer research opportunities span three highly integrated areas that are augmented and supported by a growing Quantitative Biology program with dedicated faculty and resources. The cancer research areas include;1) Cancer Gene Discovery - sequencing, genetic models, chromosome engineering;2) Cancer Gene Function - splicing, replication, epigenetics, nuclear structure, tumor growth and metastasis;and 3) Human Cancer Impact - drug sensitivity and resistance, clinical correlates, disease status and outcomes. CSHL is seeking National Research Service Award Institutional Training grant support from the NCI for 5 positions in the first year, and 6 in each of the following four years. The training program benefits from a collaborative and multidisciplinary research environment, an internal Executive Committee that includes trainee participation, and an independent External Advisory Committee. Trainees gain an in-depth and integrated understanding of cancer genetics and its impact on biological processes relevant to human malignancy, and will be prepared to pursue independent cancer research careers upon completion of the program. Points raised by the previous review panel have been carefully considered and are addressed in this revised application.

Public Health Relevance

The CSHL Cancer Gene Discovery and Cancer Biology Postdoctoral Training Program will prepare new cancer biologists to pursue independent research integrating cancer gene discovery with functional biology to facilitate the development of novel cancer therapeutic, diagnostic and preventive strategies. The program will prepare highly trained cancer research leaders to address the nation's evolving cancer research needs.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Program Officer
Lim, Susan E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Cold Spring Harbor Laboratory
Cold Spring Harbor
United States
Zip Code
Öhlund, Daniel; Handly-Santana, Abram; Biffi, Giulia et al. (2017) Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer. J Exp Med 214:579-596
Chen, Muhan; Nowak, Dawid G; Narula, Navneet et al. (2017) The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein. J Cell Biol 216:641-656
Nakamuta, Shinichi; Yang, Yu-Ting; Wang, Chia-Lin et al. (2017) Dual role for DOCK7 in tangential migration of interneuron precursors in the postnatal forebrain. J Cell Biol 216:4313-4330
Nielsen, Sebastian R; Quaranta, Valeria; Linford, Andrea et al. (2016) Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis. Nat Cell Biol 18:549-60
Seifert, Lena; Werba, Gregor; Tiwari, Shaun et al. (2016) The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression. Nature 532:245-9
Baker, Lindsey A; Tiriac, Hervé; Clevers, Hans et al. (2016) Modeling pancreatic cancer with organoids. Trends Cancer 2:176-190
Naguib, Adam; Bencze, Gyula; Engle, Dannielle D et al. (2015) p53 mutations change phosphatidylinositol acyl chain composition. Cell Rep 10:8-19
Boj, Sylvia F; Hwang, Chang-Il; Baker, Lindsey A et al. (2015) Organoid models of human and mouse ductal pancreatic cancer. Cell 160:324-38
Zambirinis, Constantinos P; Levie, Elliot; Nguy, Susanna et al. (2015) TLR9 ligation in pancreatic stellate cells promotes tumorigenesis. J Exp Med 212:2077-94
Cho, Hyejin; Herzka, Tali; Stahlhut, Carlos et al. (2015) Rapid in vivo validation of candidate drivers derived from the PTEN-mutant prostate metastasis genome. Methods 77-78:197-204

Showing the most recent 10 out of 15 publications