The multidisciplinary UAB """"""""Research Training Program in Basic and Translational Oncology"""""""" is focused on training highly motivated pre-doctoral students as well as PhD and MD graduates in the fields of translational and fundamental oncology. Major strengths of the program include the broad expertise and research interests of its faculty, encompassing tumor immunology, cancer genetics, mouse models of cancers, statistical genetics, next-generation sequencing of various cancers, preclinical models of novel targeted therapies, as well as phase 1 and phase 2 clinical studies. In the first year two postdoctoral trainees will be selected from the hematology/oncology fellowship program and among a large pool of postdoctoral fellows conducting oncology research at UAB. Their training will last up to three years. The training program will grow into three postdoctoral fellows and one pre-doctoral student by year two and three of the five year training program, respectively. The postdoctoral trainees with a MD, PhD or equivalent terminal degree will be selected on the basis of prior academic and research performance, letters of recommendations, and personal interviews. This will include highly qualified students from the Medical Scientist Training Program. While this is a new application, UAB had an active hematology research training program from 1991 until 2004 when the former cancer center director and the former division of hematology/oncology director resigned. A new cancer center director was appointed in 2007 and a new director of the division of hematology/oncology was appointed in 2008. Under this new leadership a large number of well-funded investigators with a focus on cancer research have been hired and strengthen an already very strong core of oncology researchers. Because a large number of the faculty members is involved in the care of patients with a diagnosis of cancer in addition to their research programs, the program offers an optimal interface between basic and applied oncology.

Public Health Relevance

The multidisciplinary UAB Research Training Program in Basic and Translational Oncology is focused on training highly motivated pre-doctoral students and PhD and MD graduates in the fields of fundamental and clinical oncology. Our trainees are selected for their commitment to research and academic medicine. The success of their future investigator-initiated studies, which are best represented by R01-caliber projects, requires the development of skilled creativity and the ability to identify and achieve scientific goals of significance to the biomedical research enterprise.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
1T32CA183926-01
Application #
8667643
Study Section
Subcommittee G - Education (NCI)
Program Officer
Damico, Mark W
Project Start
2014-08-05
Project End
2019-07-31
Budget Start
2014-08-05
Budget End
2015-07-31
Support Year
1
Fiscal Year
2014
Total Cost
$127,759
Indirect Cost
$8,981
Name
University of Alabama Birmingham
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Turner, Taylor B; Meza-Perez, Selene; Londoño, Angelina et al. (2017) Epigenetic modifiers upregulate MHC II and impede ovarian cancer tumor growth. Oncotarget 8:44159-44170
Bhutiani, Neal; Grizzle, William E; Galandiuk, Susan et al. (2017) Noninvasive Imaging of Colitis Using Multispectral Optoacoustic Tomography. J Nucl Med 58:1009-1012
Zeng, Ling; Beggs, Reena R; Cooper, Tiffiny S et al. (2017) Combining Chk1/2 Inhibition with Cetuximab and Radiation Enhances In Vitro and In Vivo Cytotoxicity in Head and Neck Squamous Cell Carcinoma. Mol Cancer Ther 16:591-600
Levy, Seth; Feduska, Joseph M; Sawant, Anandi et al. (2016) Immature myeloid cells are critical for enhancing bone fracture healing through angiogenic cascade. Bone 93:113-124
Grizzle, William E; Otali, Dennis; Sexton, Katherine C et al. (2016) Effects of Cold Ischemia on Gene Expression: A Review and Commentary. Biopreserv Biobank 14:548-558
Craig, Eric R; Londoño, Angelina I; Norian, Lyse A et al. (2016) Metabolic risk factors and mechanisms of disease in epithelial ovarian cancer: A review. Gynecol Oncol 143:674-683
Arend, Rebecca C; Londoño-Joshi, Angelina I; Gangrade, Abhishek et al. (2016) Niclosamide and its analogs are potent inhibitors of Wnt/?-catenin, mTOR and STAT3 signaling in ovarian cancer. Oncotarget 7:86803-86815
Atherton, Daniel S; Sexton, Katherine C; Otali, Dennis et al. (2016) Factors Affecting the Use of Human Tissues in Biomedical Research: Implications in the Design and Operation of a Biorepository. Methods Mol Biol 1381:1-38
Otali, D; Fredenburgh, J; Oelschlager, D K et al. (2016) A standard tissue as a control for histochemical and immunohistochemical staining. Biotech Histochem 91:309-26