This is a proposal to renew an ongoing and successful postdoctoral clinical research training program on the human behavioral pharmacology of substance abuse, for its 36th thru 40th years of operation. Ten training positions are proposed, all at the postdoctoral level. Training duration is two to three years. The goal is to produce experts in various aspects of substance abuse, psychopharmacology, and treatment who go on to succeed as independent clinical researchers, scientists, academicians, and administrators in drug abuse and related fields. The program has a long and successful history, with many distinguished graduates. The overarching purpose of the program is to provide training and experience in translational experimental clinical trials research methods, extending from the human laboratory to the clinic. Major sub-themes or foci within this broader purpose are to provide research training in: (a) Clinical pharmacology of drug abuse and of medications for treating drug abuse; (b) Behavioral and pharmacological treatments for drug abuse, and their integration; and (c) Behavioral and neuropsychiatric assessment of drug effects and of drug abusers, including psychiatric comorbidity, cognitive and psychomotor functioning, and risk behaviors. Training consists primarily of conducting supervised clinical research in collaboration with training faculty and analyzing and publishing the results, conclusions and implications of that research. Trainees attend and report at major scientific meetings and participate in an organized program of educational seminars designed to provide both breadth and depth to their knowledge and skills relevant to drug abuse and clinical research. The training program site is a multifaceted drug abuse clinical research program -- the Behavioral Pharmacology Research Unit -- plus other affiliated drug abuse treatment and research programs, primarily on the same campus, but extending more broadly into the community as well. Areas in which training resources have been strengthened since prior renewal include: pain, sleep, genetics, and neuroimaging. Research training is provided in the following areas: clinical pharmacology of drugs of abuse; medications development research; the cognitive neuroscience and behavioral toxicity of drugs of abuse; abuse liability assessment; pharmacological treatment of drug abuse; behavioral treatment of drug abuse, especially incentive-based strategies; integration of behavioral and pharmacological treatments; psychiatric and medical comorbidity; behavioral and neuropsychiatric assessment; HIV risk behavior assessment; addiction and pregnancy; promotion of engagement and adherence; and clinical trials research methods and trials management. Training includes a broad range of abused drug classes - opioids, cocaine, prescription medications, cannabis, club drugs/psychedelics, alcohol, tobacco/nicotine, and caffeine.

Public Health Relevance

This will renew an ongoing and successful postdoctoral clinical research training program on substance abuse that provides training in translational experimental clinical trials research methods; extending from the human laboratory to the clinic. Major foci include: (a) Clinical pharmacology and medications development; (b) Behavioral and pharmacological treatments and their integration; and (c) Behavioral/neuropsychiatric assessment, including toxicity, cognitive function, and risk behaviors.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Institutional National Research Service Award (T32)
Project #
5T32DA007209-37
Application #
9282632
Study Section
Special Emphasis Panel (ZDA1)
Program Officer
Kautz, Mary A
Project Start
1981-02-01
Project End
2021-06-30
Budget Start
2017-07-01
Budget End
2018-06-30
Support Year
37
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21205
Silverman, Kenneth; Holtyn, August F; Subramaniam, Shrinidhi (2018) Behavior analysts in the war on poverty: Developing an operant antipoverty program. Exp Clin Psychopharmacol 26:515-524
Carbonaro, Theresa M; Johnson, Matthew W; Hurwitz, Ethan et al. (2018) Double-blind comparison of the two hallucinogens psilocybin and dextromethorphan: similarities and differences in subjective experiences. Psychopharmacology (Berl) 235:521-534
Jarvis, Brantley P; DeFulio, Anthony; Long, Lauren et al. (2018) Factors associated with using opiates while under extended-release naltrexone blockade: A descriptive pilot study. J Subst Abuse Treat 85:56-60
Huhn, Andrew S; Garcia-Romeu, Albert Perez; Dunn, Kelly E (2018) Opioid Overdose Education for Individuals Prescribed Opioids for Pain Management: Randomized Comparison of Two Computer-Based Interventions. Front Psychiatry 9:34
Morris, David H; Davis, Alan K; Lauritsen, Kirstin J et al. (2018) Substance use consequences, mental health problems, and readiness to change among Veterans seeking substance use treatment. J Subst Abuse Treat 94:113-121
Pacek, Lauren R; McClernon, F Joseph; Rass, Olga et al. (2018) Perceived risk of developing smoking-related disease among persons living with HIV. AIDS Care 30:1329-1334
Jarvis, Brantley P; Holtyn, August F; Subramaniam, Shrinidhi et al. (2018) Extended-release injectable naltrexone for opioid use disorder: a systematic review. Addiction 113:1188-1209
Huhn, Andrew S; Berry, Meredith S; Dunn, Kelly E (2018) Systematic review of sex-based differences in opioid-based effects. Int Rev Psychiatry :1-10
Davis, Alan K; Barsuglia, Joseph P; Lancelotta, Rafael et al. (2018) The epidemiology of 5-methoxy- N, N-dimethyltryptamine (5-MeO-DMT) use: Benefits, consequences, patterns of use, subjective effects, and reasons for consumption. J Psychopharmacol 32:779-792
Davis, Alan K; Renn, Elise; Windham-Herman, Austin-Marley et al. (2018) A Mixed-Method Analysis of Persisting Effects Associated with Positive Outcomes Following Ibogaine Detoxification. J Psychoactive Drugs 50:287-297

Showing the most recent 10 out of 288 publications