This institutional training program combines a broadly based curricular training in Neuroscience with research training focused upon neuroscience oriented approaches to understanding addiction. Our program provides this training in the context of the interdepartmental Neuroscience Program of our Graduate School, related graduate programs in the basic health sciences and a research environment which is characterized by a critical mass of NIDA-supported investigators who have a productive history of collaborative research. Program: The training program capitalizes on 4 general arenas of trainer-trainee interaction: curriculum, research training, multiple venues for discussion of research (seminars, symposium, retreat, travel to scientific meetings) and structured programs that promote trainee planning for success. The curriculum is based on core courses in the graduate program in Neuroscience. The curriculum emphasizes cellular and molecular, systems, and behavioral components of neuroscience, and includes a course in Neuroscience Principles of Drug Abuse. The research encompassed by trainers involves cellular neuroscience integrated with molecular and/or behavioral approaches to problems associated with drug abuse. Training in research is under the direction of 15 faculty members, all of whom are members of the graduate faculty in Neuroscience. Trainees: The proposed program provides training for 6 predoctoral and 3 postdoctoral trainees. Predoctoral trainees pursuing a Ph.D. in Neuroscience, or students in the departmentally-based graduate programs of Pharmacology, Pharmaceutics, or Comparative and Molecular Biosciences who elect to minor in neuroscience will be eligible for training under the auspices of the proposed training program. Postdoctoral training by its nature is more customized and varied according to trainer and trainee. The principle to be followed in the proposed program is that the research conducted should include collaborative efforts between laboratories so as to insure an experimental neuroscience perspective. Relevance: Understanding the neurobiological processes underlying conditions that lead to use of addictive drugs (pain and reward systems) as well as plasticity in neurotransmission that occurs with repeated substance use are fundamental to developing new therapeutic approaches that disrupt addiction and do not promote addiction.

Public Health Relevance

Understanding the neurobiological processes underlying conditions that lead to use of addictive drugs (pain and reward systems) as well as plasticity in neurotransmission that occurs with repeated substance use are fundamental to developing new therapeutic approaches that disrupt addiction and do not promote addiction. This training program fosters the development of future investigators in these areas through courses, research training, and multiple venues for the discussion of ideas at the cutting-edge of the field

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Institutional National Research Service Award (T32)
Project #
3T32DA007234-28S1
Application #
8825806
Study Section
Special Emphasis Panel (ZDA1)
Program Officer
Babecki, Beth
Project Start
1991-09-30
Project End
2017-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
28
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Neurosciences
Type
Schools of Medicine
DUNS #
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Tonn Eisinger, Katherine R; Larson, Erin B; Boulware, Marissa I et al. (2017) Membrane estrogen receptor signaling impacts the reward circuitry of the female brain to influence motivated behaviors. Steroids :
Doolen, Suzanne; Cook, Jennifer; Riedl, Maureen et al. (2017) Complement 3a receptor in dorsal horn microglia mediates pronociceptive neuropeptide signaling. Glia 65:1976-1989
Ghosh, Biswarup; Green, Matthew V; Krogh, Kelly A et al. (2016) Interleukin-1? activates an Src family kinase to stimulate the plasma membrane Ca2+ pump in hippocampal neurons. J Neurophysiol 115:1875-85
Green, Matthew V; Thayer, Stanley A (2016) NMDARs Adapt to Neurotoxic HIV Protein Tat Downstream of a GluN2A-Ubiquitin Ligase Signaling Pathway. J Neurosci 36:12640-12649
Hearing, Matthew C; Jedynak, Jakub; Ebner, Stephanie R et al. (2016) Reversal of morphine-induced cell-type-specific synaptic plasticity in the nucleus accumbens shell blocks reinstatement. Proc Natl Acad Sci U S A 113:757-62
Leong, Mai Lan; Speltz, Rebecca; Wessendorf, Martin (2016) Effects of chronic constriction injury and spared nerve injury, two models of neuropathic pain, on the numbers of neurons and glia in the rostral ventromedial medulla. Neurosci Lett 617:82-7
Jedynak, Jakub; Hearing, Matthew; Ingebretson, Anna et al. (2016) Cocaine and Amphetamine Induce Overlapping but Distinct Patterns of AMPAR Plasticity in Nucleus Accumbens Medium Spiny Neurons. Neuropsychopharmacology 41:464-76
Redish, A David; Schultheiss, Nathan W; Carter, Evan C (2016) The Computational Complexity of Valuation and Motivational Forces in Decision-Making Processes. Curr Top Behav Neurosci 27:313-33
Peterson, Brittni M; Martinez, Luis A; Meisel, Robert L et al. (2016) Estradiol impacts the endocannabinoid system in female rats to influence behavioral and structural responses to cocaine. Neuropharmacology 110:118-124
Victoria, Nicole C; Marron Fernandez de Velasco, Ezequiel; Ostrovskaya, Olga et al. (2016) G Protein-Gated K+ Channel Ablation in Forebrain Pyramidal Neurons Selectively Impairs Fear Learning. Biol Psychiatry 80:796-806

Showing the most recent 10 out of 147 publications