Despite recent advances in understanding the neurobiology of addiction, there is a persistent gap in the application of knowledge gained from basic science studies to clinical practice in the field of addiction. A new generation of behavioral, psychopharmacology, neuroimaging, molecular genetic and molecular neuroscience studies has broad clinical implications and these studies bring the potential to bridge the gap between basic and clinical research. Despite the quality of the available science, actual progress in bridging this gap depends also upon the availability of appropriately trained young scientists. This purpose of the RTFSA-P is to meet this need by providing post-doctoral training for a total of 4 physicians or PhDs interested in careers in translational or intervention research in the field of substance abuse. The proposed RTFSA-P is a two-year program in the Division of Substance Abuse (DSA), Department of Psychiatry, Yale University School of Medicine, and will afford post-doctoral trainees the opportunity to devote virtually full-time effort during the initial phase of their careers to developing the skills and experience needed to become independent researchers in the field of clinical or translational research in substance use disorders. The DSA is an ongoing, stable substance abuse research program that began in 1968 and now encompasses over 78 major funded projects including 7 Centers covering a broad scope of topics and research methodologies. This facilitates research that moves rapidly and in both directions from preclinical projects (""""""""bench"""""""") to clinical studies (""""""""bedside"""""""" and """"""""community""""""""). Applicants will be MD's or PhD post-doctoral candidates trained in specialties that include psychiatry, internal medicine, clinical psychology or neuroscience. Candidates will be selected by an admission committee based on their potential for excellence in the field of translational or intervention research in substance abuse. The RTFSA-P program includes (1) individualized research preceptorship, (2) successful completion of a translational-research project, (3) a core curriculum, which include seminars on substance abuse clinical research and treatment, biostatistics and research design, the responsible conduct of scientific research and grant writing skills and (4) individualized participation in seminars of interest in the Department, Medical School and University. The training facilities include the major institutions affiliated with Yale School of Medicine, Department of Psychiatry. At the conclusion of training, applicants will be well suited for independent careers in translational or intervention research in the field of addiction.

Public Health Relevance

Clinical and translational research is vital to the development of new treatments for substance use disorders and for understanding the underlying causes of these disorders. The proposed RTFSA-P is a two-year training program in the Division of Substance Abuse (DSA), Department of Psychiatry, Yale University School of Medicine, dedicated to training young physicians and PhD-level trainees in research in the field of clinical and translational substance abuse research. The program trains 4 fellows per year and at the end of training, fellows should be well suited for independent careers in substance abuse research.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Institutional National Research Service Award (T32)
Project #
5T32DA007238-24
Application #
8688201
Study Section
AIDS Behavioral Research Subcommittee (NIDA)
Program Officer
Aklin, Will
Project Start
1988-07-01
Project End
2016-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
24
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Yale University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
City
New Haven
State
CT
Country
United States
Zip Code
06510
Morie, Kristen P; Yip, Sarah W; Zhai, Zu Wei et al. (2017) White-matter crossing-fiber microstructure in adolescents prenatally exposed to cocaine. Drug Alcohol Depend 174:23-29
Roberts, Walter; Harrison, Emily L R; McKee, Sherry A (2017) Effects of varenicline on alcohol cue reactivity in heavy drinkers. Psychopharmacology (Berl) 234:2737-2745
Milivojevic, Verica; Ansell, Emily; Simpson, Christine et al. (2017) Peripheral Immune System Adaptations and Motivation for Alcohol in Non-Dependent Problem Drinkers. Alcohol Clin Exp Res 41:585-595
Yip, Sarah W; Morie, Kristen P; Xu, Jiansong et al. (2017) Shared microstructural features of behavioral and substance addictions revealed in areas of crossing fibers. Biol Psychiatry Cogn Neurosci Neuroimaging 2:188-195
Liu, Lu; Yip, Sarah W; Zhang, Jin-Tao et al. (2017) Activation of the ventral and dorsal striatum during cue reactivity in Internet gaming disorder. Addict Biol 22:791-801
Milivojevic, Verica; Fox, Helen C; Jayaram-Lindstrom, Nitya et al. (2017) Sex differences in guanfacine effects on stress-induced stroop performance in cocaine dependence. Drug Alcohol Depend 179:275-279
Verplaetse, Terril L; Smith, Philip H; Smith, Kathryn M Z et al. (2017) Guanfacine alters the effect of stress and smoking on heart rate variability in regular daily smokers. Psychopharmacology (Berl) 234:805-813
Verplaetse, Terril L; McKee, Sherry A (2017) An overview of alcohol and tobacco/nicotine interactions in the human laboratory. Am J Drug Alcohol Abuse 43:186-196
Serafini, Kelly; Bryant, Katurah; Ikomi, Jolomi et al. (2016) Training Psychiatry Addiction Fellows in Acupuncture. Acad Psychiatry 40:503-6
Serafini, Kelly; Toohey, Michael J; Kiluk, Brian D et al. (2016) Anger and its Association with Substance Use Treatment Outcomes in a Sample of Adolescents. J Child Adolesc Subst Abuse 25:391-398

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