This is the competitive renewal of a T32 training program, the Research Training Fellowship in Substance Abuse Program (RTFSA-P), which has been in existence since 1998. Despite recent advances in understanding the neurobiology of addiction, there is a persistent gap in the application of knowledge gained from basic science studies to clinical practice in the field of addiction. A new generation of behavioral, psychopharmacology, neuroimaging, molecular genetics and molecular neuroscience studies has broad clinical implications and these studies bring the potential to bridge the gap between basic and clinical research. Despite the quality of the available science, actual progress in bridging this gap depends also upon the availability of appropriately trained young scientists. This purpose of the RTFSA-P is to meet this need by providing post-doctoral training for a total of 4 physicians or PhDs interested in careers in translational or intervention research in the fiel of substance abuse. The proposed RTFSA-P is a two-year program in the Division of Substance Abuse (DSA), Department of Psychiatry, Yale University School of Medicine, and will afford post-doctoral trainees the opportunity to devote virtually full-time effort during the initial phas of their careers to developing the skills and experience needed to become independent researchers in the field of clinical or translational research in substance use disorders. The DSA is an ongoing, stable substance abuse research program that now encompasses over 98 major funded projects including 5 Centers (and another one that is currently undergoing competitive renewal) covering a broad scope of topics and research methodologies. This facilitates research that moves rapidly and in both directions from preclinical projects (bench) to clinical studies (bedside and community). Applicants will be MD's or PhD post-doctoral candidates trained in specialties that include psychiatry, internal medicine, clinical psychology or neuroscience. Candidates will be selected by an admission committee based on their potential for excellence in the field of translational or intervention research in substance abuse. The RTFSA-P program includes (1) individualized research preceptorship, (2) successful completion of a translational-research project, (3) a core curriculum, which include seminars on substance abuse clinical research and treatment, biostatistics and research design, the responsible conduct of scientific research and grant writing skills and (4) individualized participation in seminars of interest in te Department, Medical School and University. The training facilities include the major institutions affiliated with Yale School of Medicine, Department of Psychiatry. At the conclusion of training, applicants will be well suited for independent careers in translational or intervention research in the field of addiction.

Public Health Relevance

Clinical and translational research is vital to the development of new treatments for substance use disorders and for understanding the underlying neurobiological causes of these disorders. The Research Training Fellowship in Substance Abuse Program (RTFSA-P) is a well-established program within the Division of Substance Abuse (DSA) at the Yale School of Medicine Department of Psychiatry that is dedicated to training young physicians and PhD-level trainees in translational research that spans from basic science studies to clinical neuroscience research related to drug use disorders. The program trains 4 fellows per year and at the end of training, fellows should be well suited for independent careers in addiction research.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Institutional National Research Service Award (T32)
Project #
2T32DA007238-26
Application #
9073049
Study Section
Special Emphasis Panel (ZDA1)
Program Officer
Aklin, Will
Project Start
1988-07-01
Project End
2021-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
26
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Yale University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
Verplaetse, Terril L; Moore, Kelly E; Pittman, Brian P et al. (2018) Intersection of stress and gender in association with transitions in past year DSM-5 substance use disorder diagnoses in the United States. Chronic Stress (Thousand Oaks) 2:
Roberts, Walter; Shi, Julia M; Tetrault, Jeanette M et al. (2018) Effects of Varenicline Alone and in Combination With Low-dose Naltrexone on Alcohol-primed Smoking in Heavy-drinking Tobacco Users: A Preliminary Laboratory Study. J Addict Med 12:227-233
Arout, Caroline A; Sofuoglu, Mehmet; Bastian, Lori A et al. (2018) Gender Differences in the Prevalence of Fibromyalgia and in Concomitant Medical and Psychiatric Disorders: A National Veterans Health Administration Study. J Womens Health (Larchmt) 27:1035-1044
Peltier, MacKenzie R; Sofuoglu, Mehmet (2018) Role of Exogenous Progesterone in the Treatment of Men and Women with Substance Use Disorders: A Narrative Review. CNS Drugs :
Roberts, Walter; Verplaetse, Terril L; Moore, Kelly E et al. (2018) A preliminary investigation into the effects of doxazosin on cognitive functioning in tobacco-deprived and -satiated smokers. Hum Psychopharmacol 33:e2660
Verplaetse, Terril L; Weinberger, Andrea H; Ashare, Rebecca L et al. (2018) Pilot investigation of the effect of carvedilol on stress-precipitated smoking-lapse behavior. J Psychopharmacol 32:1003-1009
Roberts, Walter; Ralevski, Elizabeth; Verplaetse, Terril L et al. (2018) Tobacco use during a clinical trial of mecamylamine for alcohol dependence: Medication effects on smoking and associations with reductions in drinking. J Subst Abuse Treat 94:91-96
Roberts, Walter; Moore, Kelly E; Peltier, MacKenzie R et al. (2018) Electronic Cigarette Use and Risk of Harmful Alcohol Consumption in the U.S. Population. Alcohol Clin Exp Res 42:2385-2393
Roberts, Walter; McKee, Sherry A (2018) Effects of varenicline on cognitive performance in heavy drinkers: Dose-response effects and associations with drinking outcomes. Exp Clin Psychopharmacol 26:49-57
Peltier, MacKenzie R; Roys, Melanie R; Waters, Aaron F et al. (2018) Motivation and readiness for tobacco cessation among nicotine dependent postmenopausal females: A pilot study. Exp Clin Psychopharmacol 26:125-131

Showing the most recent 10 out of 130 publications