The program proposed here is a continuation of an interdisciplinary, predoctoral training program in research related to drug abuse. The objective of this program continues to be the preparation of individuals for research, professional and teaching careers focused on drug abuse. Students are drawn from the Behavioral Neuroscience Program within the Department of Psychology or the Curriculum in Neurobiology at the University of North Carolina at Chapel Hill. The environment offered by UNC/Chapel Hill Is particularly well suited for training in research related to drug abuse. First of all, the faculty includes a core of individuals whose research and teaching activities provide a broad spectrum of high-quality, research training opportunities. These include the neurobiology of dopamine and opioid systems, the neuropharmacology of ethanol and other drugs of abuse, investigations of the immune system and drugs of abuse, behavioral genetics of drugs of abuse, and the behavioral, neurobiological and endocrine effects of cocaine and other psychomotor stimulants. Secondly, the interaction among investigators provides a strong collaborative environment for training students. All trainees receive formal training in the basic neural and behavioral sciences. More focused training related to drug abuse comes from a variety of interdepartmental courses and seminars and extensive laboratory research. Trainees also take part in conferences at national meetings, and receive training in teaching and communication. They participate in courses and discussions related to the ethical conduct of research, and are provided many opportunities to develop their professional leadership skills, including writing proposals and making formal presentations. Upon completion of their training, students are prepared to pursue a career related to drug abuse in academic or research-intensive settings.

Public Health Relevance

Drug abuse remains a pressing problem in this country and the interdisciplinary training program proposed here addresses that problem by preparing individuals with the skills necessary to advance knowledge of the behavioral, neurobiological and pharmacological effects of drugs of abuse This knowledge is central to the development of treatments for those who are dependent upon drugs of abuse and for the prevention of drug abuse in others.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Institutional National Research Service Award (T32)
Project #
5T32DA007244-25
Application #
8692721
Study Section
AIDS Behavioral Research Subcommittee (NIDA)
Program Officer
Lynch, Minda
Project Start
1990-09-30
Project End
2015-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
25
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Elton, Amanda; Smith, Christopher T; Parrish, Michael H et al. (2016) Neural Systems Underlying Individual Differences in Intertemporal Decision-making. J Cogn Neurosci :1-13
Saddoris, Michael P; Wang, Xuefei; Sugam, Jonathan A et al. (2016) Cocaine Self-Administration Experience Induces Pathological Phasic Accumbens Dopamine Signals and Abnormal Incentive Behaviors in Drug-Abstinent Rats. J Neurosci 36:235-50
Stringfield, Sierra J; Higginbotham, Jessica A; Fuchs, Rita A (2016) Requisite Role of Basolateral Amygdala Glucocorticoid Receptor Stimulation in Drug Context-Induced Cocaine-Seeking Behavior. Int J Neuropsychopharmacol :
Xu, Changqing; Hermes, Douglas J; Mackie, Ken et al. (2016) Cannabinoids Occlude the HIV-1 Tat-Induced Decrease in GABAergic Neurotransmission in Prefrontal Cortex Slices. J Neuroimmune Pharmacol 11:316-31
Sprow, Gretchen M; Rinker, Jennifer A; Lowery-Gointa, Emily G et al. (2016) Lateral hypothalamic melanocortin receptor signaling modulates binge-like ethanol drinking in C57BL/6J mice. Addict Biol 21:835-46
Scofield, Michael D; Li, Hao; Siemsen, Benjamin M et al. (2016) Cocaine Self-Administration and Extinction Leads to Reduced Glial Fibrillary Acidic Protein Expression and Morphometric Features of Astrocytes in the Nucleus Accumbens Core. Biol Psychiatry 80:207-15
Marshall, S Alex; Casachahua, John D; Rinker, Jennifer A et al. (2016) IL-1 receptor signaling in the basolateral amygdala modulates binge-like ethanol consumption in male C57BL/6J mice. Brain Behav Immun 51:258-67
Wells, Audrey M; Xie, Xiaohu; Higginbotham, Jessica A et al. (2016) Contribution of an SFK-Mediated Signaling Pathway in the Dorsal Hippocampus to Cocaine-Memory Reconsolidation in Rats. Neuropsychopharmacology 41:675-85
Smith, Christopher T; Wallace, Deanna L; Dang, Linh C et al. (2016) Modulation of impulsivity and reward sensitivity in intertemporal choice by striatal and midbrain dopamine synthesis in healthy adults. J Neurophysiol 115:1146-56
Lebonville, Christina L; Jones, Meghan E; Hutson, Lee W et al. (2016) Acquisition of heroin conditioned immunosuppression requires IL-1 signaling in the dorsal hippocampus. Brain Behav Immun 56:325-34

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