The program proposed here is a continuation of an interdisciplinary, predoctoral training program in research related to drug abuse. The objective of this program continues to be the preparation of individuals for research, professional and teaching careers focused on drug abuse. Students are drawn from the Behavioral Neuroscience Program within the Department of Psychology or the Curriculum in Neurobiology at the University of North Carolina at Chapel Hill. The environment offered by UNC/Chapel Hill Is particularly well suited for training in research related to drug abuse. First of all, the faculty includes a core of individuals whose research and teaching activities provide a broad spectrum of high-quality, research training opportunities. These include the neurobiology of dopamine and opioid systems, the neuropharmacology of ethanol and other drugs of abuse, investigations of the immune system and drugs of abuse, behavioral genetics of drugs of abuse, and the behavioral, neurobiological and endocrine effects of cocaine and other psychomotor stimulants. Secondly, the interaction among investigators provides a strong collaborative environment for training students. All trainees receive formal training in the basic neural and behavioral sciences. More focused training related to drug abuse comes from a variety of interdepartmental courses and seminars and extensive laboratory research. Trainees also take part in conferences at national meetings, and receive training in teaching and communication. They participate in courses and discussions related to the ethical conduct of research, and are provided many opportunities to develop their professional leadership skills, including writing proposals and making formal presentations. Upon completion of their training, students are prepared to pursue a career related to drug abuse in academic or research-intensive settings.
Drug abuse remains a pressing problem in this country and the interdisciplinary training program proposed here addresses that problem by preparing individuals with the skills necessary to advance knowledge of the behavioral, neurobiological and pharmacological effects of drugs of abuse This knowledge is central to the development of treatments for those who are dependent upon drugs of abuse and for the prevention of drug abuse in others.
|Haake, Rachel M; West, Elizabeth A; Wang, Xuefei et al. (2018) Drug-induced dysphoria is enhanced following prolonged cocaine abstinence and dynamically tracked by nucleus accumbens neurons. Addict Biol :|
|Hermes, Douglas J; Xu, Changqing; Poklis, Justin L et al. (2018) Neuroprotective effects of fatty acid amide hydrolase catabolic enzyme inhibition in a HIV-1 Tat model of neuroAIDS. Neuropharmacology 141:55-65|
|Sepulveda-Orengo, Marian T; Healey, Kati L; Kim, Ronald et al. (2018) Riluzole Impairs Cocaine Reinstatement and Restores Adaptations in Intrinsic Excitability and GLT-1 Expression. Neuropsychopharmacology 43:1212-1223|
|Kim, Ronald; Sepulveda-Orengo, Marian T; Healey, Kati L et al. (2018) Regulation of glutamate transporter 1 (GLT-1) gene expression by cocaine self-administration and withdrawal. Neuropharmacology 128:1-10|
|Paniccia, Jacqueline E; Lebonville, Christina L; Jones, Meghan E et al. (2018) Dorsal hippocampal neural immune signaling regulates heroin-conditioned immunomodulation but not heroin-conditioned place preference. Brain Behav Immun 73:698-707|
|Companion, Michel A; Thiele, Todd E (2018) Assessment of ventral tegmental area-projecting GABAergic neurons from the bed nucleus of the stria terminalis in modulating binge-like ethanol intake. Eur J Neurosci 48:3335-3343|
|Decot, Heather K; Namboodiri, Vijay M K; Gao, Wei et al. (2017) Coordination of Brain-Wide Activity Dynamics by Dopaminergic Neurons. Neuropsychopharmacology 42:615-627|
|Daughters, Stacey B; Ross, Thomas J; Bell, Ryan P et al. (2017) Distress tolerance among substance users is associated with functional connectivity between prefrontal regions during a distress tolerance task. Addict Biol 22:1378-1390|
|Burnham, Nathan W; Thiele, Todd E (2017) Voluntary Binge-like Ethanol Consumption Site-specifically Increases c-Fos Immunoexpression in Male C57BL6/J Mice. Neuroscience 367:159-168|
|Saddoris, Michael P; Sugam, Jonathan A; Carelli, Regina M (2017) Prior Cocaine Experience Impairs Normal Phasic Dopamine Signals of Reward Value in Accumbens Shell. Neuropsychopharmacology 42:766-773|
Showing the most recent 10 out of 80 publications