The overall objective of the NIDA Training Program in Drug Abuse Research at The University of Chicago is to provide both pre- and postdoctoral trainees with comprehensive educational and research experiences that will enable them to pursue distinguished research careers in areas impacting drug abuse. Drug abuse poses a serious threat to the health and well being of both individuals and society. Mental status, physical health, social function and economic productivity are compromised. Such factors can lead to an increase in crime and violence. To the credit of NIDA-sponsored research programs, considerable gains have been made over the last two decades. However, much more remains to be learned from the molecular to the social realm, especially if knowledge is to be translated into effective treatment. Existing programs in the area of drug abuse at The University of Chicago are designed to acquire knowledge about the social, behavioral, neuropharmacological, molecular and genetic factors relevant to the abuse of drugs.
The aim i s to increase our understanding of the etiology of and our ability to intervene in the treatment and prevention of drug abuse. Specific strengths of this program relate to the neuropharmacology, psychopharmacology, electrophysiology, genetics and molecular biology of drug abuse as well as the behavioral and subjective effects of drugs in humans. Several factors place the faculty submitting this application in an excellent position to continue to offer an outstanding training program. These factors include the strength of current interests and ongoing research into the problems of drug abuse, the diversity of approaches employed by individual faculty, the presence of a critical mass of creative scientists working on drug abuse related problems in a multidisciplinary setting as well as a curriculum that addresses the broad aspects of drug abuse ranging from the molecular bases of drug action to the consideration of ethical and social issues related to drug taking.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Institutional National Research Service Award (T32)
Project #
3T32DA007255-20S1
Application #
8532565
Study Section
Special Emphasis Panel (ZDA1-MXS-M (21))
Program Officer
Babecki, Beth
Project Start
1991-09-30
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2014-06-30
Support Year
20
Fiscal Year
2012
Total Cost
$106,412
Indirect Cost
$18,345
Name
University of Chicago
Department
Biology
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
van den Berg, Stéphanie M; de Moor, Marleen H M; Verweij, Karin J H et al. (2016) Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium. Behav Genet 46:170-82
Parker, Clarissa C; Gopalakrishnan, Shyam; Carbonetto, Peter et al. (2016) Genome-wide association study of behavioral, physiological and gene expression traits in outbred CFW mice. Nat Genet 48:919-26
McDaid, John; Abburi, Chandrika; Wolfman, Shannon L et al. (2016) Ethanol-Induced Motor Impairment Mediated by Inhibition of α7 Nicotinic Receptors. J Neurosci 36:7768-78
Singer, Bryan F; Bubula, Nancy; Przybycien-Szymanska, Magdalena M et al. (2016) Stimuli associated with the presence or absence of amphetamine regulate cytoskeletal signaling and behavior. Eur Neuropsychopharmacol 26:1836-1842
Young, E E; Bryant, C D; Lee, S E et al. (2016) Systems genetic and pharmacological analysis identifies candidate genes underlying mechanosensation in the von Frey test. Genes Brain Behav 15:604-15
Singer, Bryan F; Bubula, Nancy; Li, Dongdong et al. (2016) Drug-Paired Contextual Stimuli Increase Dendritic Spine Dynamics in Select Nucleus Accumbens Neurons. Neuropsychopharmacology 41:2178-87
Clark, Christine M; Frye, Charles G; Wardle, Margaret C et al. (2015) Acute effects of MDMA on autonomic cardiac activity and their relation to subjective prosocial and stimulant effects. Psychophysiology 52:429-35
Yarosh, Haley L; Meda, Shashwath A; de Wit, Harriet et al. (2015) Multivariate analysis of subjective responses to d-amphetamine in healthy volunteers finds novel genetic pathway associations. Psychopharmacology (Berl) 232:2781-94
Genetics of Personality Consortium; de Moor, Marleen H M; van den Berg, Stéphanie M et al. (2015) Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder. JAMA Psychiatry 72:642-50
Frye, Charles G; Wardle, Margaret C; Norman, Greg J et al. (2014) MDMA decreases the effects of simulated social rejection. Pharmacol Biochem Behav 117:1-6

Showing the most recent 10 out of 118 publications