This program for pre- and post-doctoral training supports the training of specialists who are able to conduct preclinical research at levels ranging from the molecular to the cognitive/clinical, on the biological mechanisms underlying the development, maintenance, and elimination of drug-seeking behavior. Thirty-two members of the graduate faculty of the Oregon Health &Science University serve as preceptors for postdoctoral research fellows and for Ph.D. students matriculating into basic science graduate programs in behavioral neuroscience, neuroscience, physiology and pharmacology, or biochemistry. Major research areas represent four levels. Some faculty members work primarily at the cellular/molecular level, using molecular biological, cell biological, and electron microscopic techniques. Other faculty work principally at the level of physiological, biochemical and pharmacological systems, using receptor binding, autoradiography, in vivo microdialysis and voltammetry, and electrophysiological techniques, and some work primarily in behavioral pharmacology and pharmacogenetics, using behavioral testing, intravenous drug self-administration, quantitative genetics and genetic mapping, as well as computer modeling techniques. Finally, some faculty work with human subjects, using cognitive testing and a variety of imaging techniques. Areas of extensive existing faculty collaboration include: studies of dopaminergic systems, ranging from molecular biology to behavior;extensive studies of genetic determinants of drug responses, at all levels from molecular to statistical gene mapping;and the study of learned and unlearned determinants of responses to drugs, particularly their rewarding effects and drug self- administration. Sensitivity, tolerance, and dependence/withdrawal phenomena for all major classes of drugs of abuse are under active investigation. Training includes firm curricular grounding in the basic sciences, specific pharmacological training in abused drugs, and extensive and continuous participation in research.

Public Health Relevance

Drug abuse has tremendous personal and societal costs. This program trains scientists to carry out research to identify mechanisms of the processes of becoming addicted to drugs and of stopping drug taking, and to develop treatments to prevent renewed drug taking by abstinent addicts.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Babecki, Beth
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Oregon Health and Science University
Other Basic Sciences
Schools of Medicine
United States
Zip Code
Tipps, Megan E; Moschak, Travis M; Mitchell, Suzanne H (2014) Behavioral disinhibition in mice bred for high drinking in the dark (HDID) and HS controls increases following ethanol. Drug Alcohol Depend 136:149-52
Zuloaga, Damian G; Johnson, Lance A; Agam, Maayan et al. (2014) Sex differences in activation of the hypothalamic-pituitary-adrenal axis by methamphetamine. J Neurochem 129:495-508
Piper, Brian J; Gray, Hilary M; Corbett, Selena M et al. (2014) Executive function and mental health in adopted children with a history of recreational drug exposures. PLoS One 9:e110459
Raybuck, J D; Lattal, K M (2014) Differential effects of dorsal hippocampal inactivation on expression of recent and remote drug and fear memory. Neurosci Lett 569:1-5
Pina, Melanie M; Cunningham, Christopher L (2014) Effects of the novel cannabinoid CB1 receptor antagonist PF 514273 on the acquisition and expression of ethanol conditioned place preference. Alcohol 48:427-31
Raber, Jacob; Olsen, Reid H J; Su, Weiping et al. (2014) CD44 is required for spatial memory retention and sensorimotor functions. Behav Brain Res 275:146-9
Pina, Melanie M; Cunningham, Christopher L (2014) Effects of dopamine receptor antagonists on the acquisition of ethanol-induced conditioned place preference in mice. Psychopharmacology (Berl) 231:459-68
Tipps, Megan E; Raybuck, Jonathan D; Lattal, K Matthew (2014) Substance abuse, memory, and post-traumatic stress disorder. Neurobiol Learn Mem 112:87-100
Abraham, Antony D; Neve, Kim A; Lattal, K Matthew (2014) Dopamine and extinction: a convergence of theory with fear and reward circuitry. Neurobiol Learn Mem 108:65-77
Raybuck, Jonathan D; Lattal, K Matthew (2014) Bridging the interval: theory and neurobiology of trace conditioning. Behav Processes 101:103-11

Showing the most recent 10 out of 100 publications