The overall purpose of this training grant is to provide postdoctoral training to young basic scientists and physicians in the area of neurobiology of substance abuse, with a focus on the mode of action of psychostimulant and opiate drugs at the genetic, molecular, circuit and behavioral levels. Our objective is to provide an exciting and innovative environment with world class facilities and faculty to develop the next generation of scientists working in drug abuse. Training will take place in the multidisciplinary setting at the University of Michigan. The 17 faculty members are all NIDA grantees (or Co-Investigators) and have expertise in the neurobiology of substance abuse, with particular emphasis on the area of opioid and psychostimulant drugs. The focus of the proposal is the training of postdoctoral fellows in state-of-the-art approaches for studying mechanisms underlying abuse of psychoactive drugs. This includes studying the genetic, developmental and environmental factors that lead to vulnerability to substance abuse: the mode of action of drugs of abuse at the molecular, cellular, anatomical and behavioral levels;and the long-term consequences of psychoactive drugs on the brain, as mediated through mechanisms of neural plasticity, and the development of medications. The working assumption is that the functional and structural brain remodeling associated with chronic drug use lies at the basis of tolerance, sensitization, physical dependence, and psychological addiction to these drugs. The drug abuse research community at the University of Michigan is of high quality and has a long history in the field. Beyond their individual strengths, the training faculty members have long-term scientific and training relationships with each other. These historical strengths have recently been significantly enhanced with a number of initiatives at the University of Michigan, designed to facilitate life science research in general, and neuroscience research in particular. They include state-of-the-art tools for mouse and rat genetics, genomics, proteomics, and informatics. Thus, our postdoctoral fellows will profit from a highly sophisticated, yet supportive, research and training environment.
This grant is designed to provide postdoctoral training to young basic scientists and physicians in the area of neurobiology of substance abuse, with a focus on the mode of action of psychostimulant and opiate drugs at the genetic, molecular, circuit and behavioral levels. The objective is to provide an exciting and innovative environment with world class facilities and faculty to develop the next generation of scientists working in dru abuse. These scientists will then have the skills to continue to study and work towards solving drug abuse thus supporting the mission of NIDA.
|Ahrens, Allison M; Singer, Bryan F; Fitzpatrick, Christopher J et al. (2016) Rats that sign-track are resistant to Pavlovian but not instrumental extinction. Behav Brain Res 296:418-30|
|Vollbrecht, Peter J; Mabrouk, Omar S; Nelson, Andrew D et al. (2016) Pre-existing differences and diet-induced alterations in striatal dopamine systems of obesity-prone rats. Obesity (Silver Spring) 24:670-7|
|Singer, Bryan F; Guptaroy, Bipasha; Austin, Curtis J et al. (2016) Individual variation in incentive salience attribution and accumbens dopamine transporter expression and function. Eur J Neurosci 43:662-70|
|Zestos, Alexander G; Mikelman, Sarah R; Kennedy, Robert T et al. (2016) PKCÎ² Inhibitors Attenuate Amphetamine-Stimulated Dopamine Efflux. ACS Chem Neurosci 7:757-66|
|Oginsky, Max F; Maust, Joel D; Corthell, John T et al. (2016) Enhanced cocaine-induced locomotor sensitization and intrinsic excitability of NAc medium spiny neurons in adult but not in adolescent rats susceptible to diet-induced obesity. Psychopharmacology (Berl) 233:773-84|
|Ahrens, Allison M; Meyer, Paul J; Ferguson, Lindsay M et al. (2016) Neural Activity in the Ventral Pallidum Encodes Variation in the Incentive Value of a Reward Cue. J Neurosci 36:7957-70|
|Meyer, Paul J; King, Christopher P; Ferrario, Carrie R (2016) Motivational Processes Underlying Substance Abuse Disorder. Curr Top Behav Neurosci 27:473-506|
|Martz, Meghan E; Trucco, Elisa M; Cope, Lora M et al. (2016) Association of Marijuana Use With Blunted Nucleus Accumbens Response to Reward Anticipation. JAMA Psychiatry 73:838-44|
|Bertz, Jeremiah W; Jackson, Emily L; Barron, Davina R et al. (2016) Effects of sex and remifentanil dose on rats' acquisition of responding for a remifentanil-conditioned reinforcer. Behav Pharmacol 27:137-47|
|Hamid, Arif A; Pettibone, Jeffrey R; Mabrouk, Omar S et al. (2016) Mesolimbic dopamine signals the value of work. Nat Neurosci 19:117-26|
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