This application provides pre and postdoctoral training in Drug Abuse Research with a multidisciplinary and tri-institutional faculty that is proficient in the molecular, structural, biochemical, and behavioral and clinical aspects of Drug Abuse Research. The faculty includes members from the Departments of Pharmacology, Neuroscience and Physiology, Biophysics and Systems Biology (PBSB) at Weill Medical College of Cornell University and from the Memorial Sloan-Kettering Cancer Center (MSKCC) and The Rockefeller University. Faculty research interests include: the role of glutamatergic receptors in pain and the addictive behaviors resulting from the administration of cocaine and opioids, peptide drugs that target specific cellular targets, functional and structural magnetic resonance imaging (MRI) to examine brain circuitry involved in reinforcement learning and reward related behavior in substance use and abuse in adolescents, GABA-A receptor mediated inhibitory synapses in the brain, effects of general anesthetics on neurotransmitter release, dendritic translation and nuclear trafficking of CREB signaling induced by drugs of abuse, the role of the endogenous opioid and neuroendocrine systems in addictive diseases, role of Soluble Adenylyl Cyclase (sAC) in NGF stimulation of neuritogenesis and axonal growth cone reorganization, estrogen and opioid interactions in the hippocampus, molecular mechanisms of mu opioid receptor heterogeneity, interactions between monoamines in the brain's reward circuits, postnatal developmental disorders and effects of psychostimulants, computational analysis of hallucinogen interactions with 5-HT2a receptors. Predoctoral trainees will have a choice of a major concentration in Pharmacology, Neuroscience or PBSB. In addition to lectures and seminars devoted to topics in drug abuse, both the 5 pre and the 4 postdoctoral trainees will attend a biweekly Pain Conference at MSKCC where patient presentations are followed by a discussion with a multidisciplinary pain research team of pain management, drug abuse and related issues. The program provides training in study design, biostatistics and the ethics of scientific research. Special programs are available to identify minority trainees. The Pharmacology-Neuroscience Drug Abuse Training Program provides an opportunity for young investigators to participate in basic and clinical research in drug abuse.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Institutional National Research Service Award (T32)
Project #
5T32DA007274-20
Application #
8106080
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Babecki, Beth
Project Start
1991-09-30
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2013-06-30
Support Year
20
Fiscal Year
2011
Total Cost
$374,527
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
060217502
City
New York
State
NY
Country
United States
Zip Code
10065
Burgdorf, Caitlin E; Schierberl, Kathryn C; Lee, Anni S et al. (2017) Extinction of Contextual Cocaine Memories Requires Cav1.2 within D1R-Expressing Cells and Recruits Hippocampal Cav1.2-Dependent Signaling Mechanisms. J Neurosci 37:11894-11911
Marques-Lopes, Jose; Tesfaye, Ephrath; Israilov, Sigal et al. (2017) Redistribution of NMDA Receptors in Estrogen-Receptor-?-Containing Paraventricular Hypothalamic Neurons following Slow-Pressor Angiotensin II Hypertension in Female Mice with Accelerated Ovarian Failure. Neuroendocrinology 104:239-256
Van Kempen, Tracey A; Narayan, Ankita; Waters, Elizabeth M et al. (2016) Alterations in the subcellular distribution of NADPH oxidase p47(phox) in hypothalamic paraventricular neurons following slow-pressor angiotensin II hypertension in female mice with accelerated ovarian failure. J Comp Neurol 524:2251-65
Mazid, Sanoara; Hall, Baila S; Odell, Shannon C et al. (2016) Sex differences in subcellular distribution of delta opioid receptors in the rat hippocampus in response to acute and chronic stress. Neurobiol Stress 5:37-53
Marques-Lopes, Jose; Lynch, Mary-Katherine; Van Kempen, Tracey A et al. (2015) Female protection from slow-pressor effects of angiotensin II involves prevention of ROS production independent of NMDA receptor trafficking in hypothalamic neurons expressing angiotensin 1A receptors. Synapse 69:148-65
Van Kempen, T A; Dodos, M; Woods, C et al. (2015) Sex differences in NMDA GluN1 plasticity in rostral ventrolateral medulla neurons containing corticotropin-releasing factor type 1 receptor following slow-pressor angiotensin II hypertension. Neuroscience 307:83-97
Pickett, Julie E; Váradi, András; Palmer, Travis C et al. (2015) Mild, Pd-catalyzed stannylation of radioiodination targets. Bioorg Med Chem Lett 25:1761-1764
Baumgart, Joel P; Zhou, Zhen-Yu; Hara, Masato et al. (2015) Isoflurane inhibits synaptic vesicle exocytosis through reduced Ca2+ influx, not Ca2+-exocytosis coupling. Proc Natl Acad Sci U S A 112:11959-64
Van Kempen, Tracey A; Gorecka, Jolanta; Gonzalez, Andreina D et al. (2014) Characterization of neural estrogen signaling and neurotrophic changes in the accelerated ovarian failure mouse model of menopause. Endocrinology 155:3610-23
Marques-Lopes, Jose; Van Kempen, Tracey; Waters, Elizabeth M et al. (2014) Slow-pressor angiotensin II hypertension and concomitant dendritic NMDA receptor trafficking in estrogen receptor ?-containing neurons of the mouse hypothalamic paraventricular nucleus are sex and age dependent. J Comp Neurol 522:3075-90

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