The Division on Substance Abuse of the Columbia University Department of Psychiatry and the New York State Psychiatric Institute established a 2-year postdoctoral program that focuses on training physicians and psychologists for research careers in substance abuse. The main goal of this program, which is now in its 19th year of existence, is to provide both the research skills and clinical expertise necessary to design and carry out research on the etiology and treatment of substance use disorders. In this competing application we are requesting 5 additional years of funding for 5 fellows to be enrolled in the program each year. The program continues to include the following aspects of training: 1) Didactic introduction to clinical research in the addictions that incorporates a comprehensive overview of the substance abuse field, an introduction and advanced course in statistics, a weekly journal club and methodology seminar, and a formal course and ongoing instruction on the ethical and appropriate scientific conduct of clinical research; 2) Research apprenticeship where each trainee works as a junior collaborator under the close supervision of a senior investigator who serves as a preceptor and mentor; 3) Clinical experience in the major modalities used to treat substance abuse; and 4) Development of teaching capabilities where each fellow is provided opportunities to provide lectures/seminars to medical students, psychiatric and other medical house staff and/or present at journal clubs and scientific meetings. A new direction in the past 5 years has been to recruit and train MD/PhD candidates who concentrate on translational paradigms to better understand the physiologic and behavioral mechanisms associated with substance abuse. In the 19 years that the program has been running there has been a steady flow of high quality applicants. 47 trainees (31% females) have entered the program, including 34 physicians (30 psychiatrists, 1 neurologist, 2 internists, 1 family medicine), 1 nurse practitioner with a doctorate in public health, and 12 psychologists. In the past 5 years 3 of the physicians have been MD/PhDs. Of those who graduated in the past 10 years, 71% have gone on to academic-research positions, and 24% have entered academic clinical/teaching positions in which several have remained actively involved in research activities. Six fellows (one on a supplemental slot) are currently in training and two additional fellows will begin training in July 2012. The program has been successful in recruiting women and minority trainees. In parallel to this successful training program the faculty within the Division has continued to grow, enriched by the graduating fellows. At the first grant submission there were 9 faculty members within the Division on Substance Abuse. Currently, there are 23 faculty members, of which 11 are capable of serving as mentors. This sustained growth demonstrates how vibrant the Division on Substance Abuse is for young investigators.

Public Health Relevance

Substance abuse remains a significant public health problem that requires more effective treatment interventions. A cadre of clinical researchers is needed to explore the mechanisms of disease and to develop new behavioral and pharmacological treatments. Our long-standing program has been at the forefront of training young investigators and through continued support, our program hopes to ensure that there is a new generation of junior clinical investigators who eventually become leaders in the substance abuse field.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Institutional National Research Service Award (T32)
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Study Section
Training and Career Development Subcommittee (NIDA)
Program Officer
Aklin, Will
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Columbia University (N.Y.)
Schools of Medicine
New York
United States
Zip Code
Williams, Arthur Robin; Barbieri, Vincent; Mishlen, Kaitlyn et al. (2017) Long-term follow-up study of community-based patients receiving XR-NTX for opioid use disorders. Am J Addict 26:319-325
Williams, Arthur Robin; Santaella-Tenorio, Julian; Mauro, Christine M et al. (2017) Loose regulation of medical marijuana programs associated with higher rates of adult marijuana use but not cannabis use disorder. Addiction 112:1985-1991
Ruglass, Lesia M; Shevorykin, Alina; Radoncic, Vanja et al. (2017) Impact of Cannabis Use on Treatment Outcomes among Adults Receiving Cognitive-Behavioral Treatment for PTSD and Substance Use Disorders. J Clin Med 6:
Luo, Sean X; Levin, Frances R (2017) Towards Precision Addiction Treatment: New Findings in Co-morbid Substance Use and Attention-Deficit Hyperactivity Disorders. Curr Psychiatry Rep 19:14
Marino, Leslie; Wissow, Lawrence S; Davis, Maryann et al. (2016) Predictors of outpatient mental health clinic follow-up after hospitalization among Medicaid-enrolled young adults. Early Interv Psychiatry 10:468-475
Notzon, Daniel P; Mariani, John J; Pavlicova, Martina et al. (2016) Mixed-amphetamine salts increase abstinence from marijuana in patients with co-occurring attention-deficit/hyperactivity disorder and cocaine dependence. Am J Addict 25:666-672
Williams, Arthur Robin; Olfson, Mark; Kim, June H et al. (2016) Older, Less Regulated Medical Marijuana Programs Have Much Greater Enrollment Rates Than Newer 'Medicalized' Programs. Health Aff (Millwood) 35:480-8
Herrmann, Evan S; Cooper, Ziva D; Bedi, Gillinder et al. (2016) Effects of zolpidem alone and in combination with nabilone on cannabis withdrawal and a laboratory model of relapse in cannabis users. Psychopharmacology (Berl) 233:2469-78
Notzon, Daniel P; Pavlicova, Martina; Glass, Andrew et al. (2016) ADHD Is Highly Prevalent in Patients Seeking Treatment for Cannabis Use Disorders. J Atten Disord :
Williams, Arthur Robin (2016) Opportunities in Reform: Bioethics and Mental Health Ethics. Bioethics 30:221-6

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