Elucidation of the mechanisms by which drugs of abuse modify brain function requires knowledge of fundamental neuroscience with respect to how individual molecular components control neurotransmission and behavior. This program for predoctoral and postdoctoral fellows will provide training in basic neuroscience that is relevant to understanding how drugs of abuse modify brain function. This interdisciplinary training program by the excellent faculty of the Graduate Program in Neurosciences at the Univ. of Calif., San Diego (UCSD) will span chemistry for design and synthesis of opioid receptor ligands, biochemistry and macromolecular structure of protein components involved in neurotransmission, pharmacology of receptor-mediated signal transduction and neurophysiology, neuroimmune and viral influences on the brain, and involvement of particular neuronal systems in pain and behavior that are related to the actions of drugs of abuse. The integration of analyzing brain function at several levels-molecular biology and biochemistry, neurobiology and physiology, and neuronal circuits in pain and behavior-is required to address mechanistic hypotheses that will elucidate how chemical drugs modify specific regulatory receptors, enzymes, and other components in the nervous system that initiate changes in neurotransmission and behavior. This training program will instruct four predoctoral students in the Graduate Program in Neurosciences, and two postdoctoral trainees, in multidisciplinary and integrated research areas in neuroscience that are related to understanding how drugs of abuse modify brain function. Each trainee will be mentored by a faculty advisor of this training program. Multidisciplinary research projects involving the training faculty will be developed. Exchange of scientific knowledge among trainees and faculty will be achieved through coursework, seminars, and informal scientific discussions. The high quality faculty, and their commitment to research training, will allow this program to train young scientists who will possess the appropriate expertise and scientific rationale for future elucidation of drug actions. Furthermore, modern up-to-date facilities at UCSD that will be accessible to trainees, including the San Diego Supercomputer Center (SDSC) for structural and genomic analyses, the core transgenic mouse knock-out facility, peptide synthesis and sequencing core, and molecular and cell biology core facility. Trainees of this program will acquire the knowledge required for their continued investigations on the mechanisms of drugs of abuse.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Institutional National Research Service Award (T32)
Project #
1T32DA007315-01
Application #
6078543
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Babecki, Beth
Project Start
2000-07-01
Project End
2005-06-30
Budget Start
2000-07-01
Budget End
2001-06-30
Support Year
1
Fiscal Year
2000
Total Cost
$173,146
Indirect Cost
Name
University of California San Diego
Department
Neurosciences
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Lacin, Emre; Muller, Arnaud; Fernando, Marian et al. (2016) Construction of Cell-based Neurotransmitter Fluorescent Engineered Reporters (CNiFERs) for Optical Detection of Neurotransmitters In Vivo. J Vis Exp :
Podvin, Sonia; Yaksh, Tony; Hook, Vivian (2016) The Emerging Role of Spinal Dynorphin in Chronic Pain: A Therapeutic Perspective. Annu Rev Pharmacol Toxicol 56:511-33
Podvin, Sonia; Miller, Miles C; Rossi, Ryan et al. (2016) The Orphan C2orf40 Gene is a Neuroimmune Factor in Alzheimer's Disease. JSM Alzheimers Dis Relat Dement 3:
Bertin, Matthew J; Vulpanovici, Alexandra; Monroe, Emily A et al. (2016) The Phormidolide Biosynthetic Gene Cluster: A trans-AT PKS Pathway Encoding a Toxic Macrocyclic Polyketide. Chembiochem 17:164-73
Almatroudi, Abdulrahman; Husbands, Stephen M; Bailey, Christopher P et al. (2015) Combined administration of buprenorphine and naltrexone produces antidepressant-like effects in mice. J Psychopharmacol 29:812-21
Bushman, Diane M; Kaeser, Gwendolyn E; Siddoway, Benjamin et al. (2015) Genomic mosaicism with increased amyloid precursor protein (APP) gene copy number in single neurons from sporadic Alzheimer's disease brains. Elife 4:
Zieli?ska, Marta; Ben Haddou, Tanila; Cami-Kobeci, Gerta et al. (2015) Anti-inflammatory effect of dual nociceptin and opioid receptor agonist, BU08070, in experimental colitis in mice. Eur J Pharmacol 765:582-90
Podvin, Sonia; Bundey, Richard; Toneff, Thomas et al. (2015) Profiles of secreted neuropeptides and catecholamines illustrate similarities and differences in response to stimulation by distinct secretagogues. Mol Cell Neurosci 68:177-85
Park, Paula E; Schlosburg, Joel E; Vendruscolo, Leandro F et al. (2015) Chronic CRF1 receptor blockade reduces heroin intake escalation and dependence-induced hyperalgesia. Addict Biol 20:275-84
Miller, Bailey; Friedman, Aaron J; Choi, Hyukjae et al. (2014) The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. J Nat Prod 77:92-9

Showing the most recent 10 out of 39 publications