As the breadth and depth of multimodal neuroimaging rapidly expands, there is an important need to train individuals on how use the technology to better detect, understand, develop new medications, track and prevent drug abuse. Sophisticated MRI, PET, EEG and Near Infrared Spectroscopy (NIRS) techniques can be used to explore the neurobiological bases of drug abuse and dependence. This is a proposal to continue a T32 Institutional postdoctoral Training Program to fill an important training need in the field. The key elements of this Training Program include: two locations (McLean Hospital and MGH);participation by multiple departments from basic science to clinical treatment units;availability of training in several imaging modalities including MR, PET, EEG, NIRS;clinical and preclinical training opportunities with integrated translational research opportunities;rich breadh of NIH funded projects to support the trainees'research;group of well-seasoned mentors who have been working together for the past 9 years of this program;option of four well-defined training tracks including: 1) Technology &Instrumentation, 2) Clinical-Basic, 3) Clinical-Treatment and 4) Translational;well-designed 2-3 year training plans that integrate coursework, responsible conduct of research, lab rotations, paper &grant writing experience and independent research;very successful track record of trainees'securing independent funding upon graduation from the program;successful rate of trainee publications;and extensive institutional support for the program as evidenced by significant upgrades to our 3T and 4T clinical scanners and the addition of a 9.4T animal scanner. Over the past 9 years we have developed and maintained an integrated, multidisciplinary Drug Abuse and Brain Imaging Training Program (DABITP) that currently supports 4 postdoctoral slots;we propose to increase the number of trainees to six slots because the program is consistently full and we have expanded to include the Martinos Center for Biomedical Imaging (at MGH), which brings combined MR-PET imaging training to the program and four new training laboratories at McLean Hospital. The combination of didactic training in brain imaging and psychopharmacology with practical applications in a variety of highly successful research laboratories provides our trainees with the skills to utilize a broad range of brain imaging techniques as they embark on the next decade of research on the addicted brain.

Public Health Relevance

Sophisticated brain imaging techniques are more frequently being used to better detect, understand, develop new medications, track and prevent drug abuse. Over the past 9 years we have built and maintained an integrated, multidisciplinary Drug Abuse and Brain Imaging Training Program (DABITP) that currently supports 4 postdoctoral slots to train individuals how to merge imaging technologies with basic and applied clinical research and translational models of drug abuse in order to meet these important needs. The extensive breadth of credentials of the mentors offers the trainees the best opportunity to learn to apply these skills in order to further our understanding of the neurobiological bases of the addicted brain.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZDA1-EXL-T (13))
Program Officer
Kautz, Mary A
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Mclean Hospital Coroporation
United States
Zip Code
McHugh, R Kathryn; Kertz, Sarah J; Weiss, Rachel B et al. (2014) Changes in distress intolerance and treatment outcome in a partial hospital setting. Behav Ther 45:232-40
Du, Fei; Cooper, Alissa J; Thida, Thida et al. (2014) In vivo evidence for cerebral bioenergetic abnormalities in schizophrenia measured using 31P magnetization transfer spectroscopy. JAMA Psychiatry 71:19-27
Rohan, Michael L; Yamamoto, Rinah T; Ravichandran, Caitlin T et al. (2014) Rapid mood-elevating effects of low field magnetic stimulation in depression. Biol Psychiatry 76:186-93
Balu, Darrick T; Takagi, Shunsuke; Puhl, Matthew D et al. (2014) D-serine and serine racemase are localized to neurons in the adult mouse and human forebrain. Cell Mol Neurobiol 34:419-35
Baskin-Sommers, Arielle; Krusemark, Elizabeth; Ronningstam, Elsa (2014) Empathy in narcissistic personality disorder: from clinical and empirical perspectives. Personal Disord 5:323-33
Bracken, Bethany K; Rodolico, John; Hill, Kevin P (2013) Sex, age, and progression of drug use in adolescents admitted for substance use disorder treatment in the northeastern United States: comparison with a national survey. Subst Abus 34:263-72
Lindsey, Kimberly P; Bracken, Bethany K; Maclean, Robert R et al. (2013) Nicotine content and abstinence state have different effects on subjective ratings of positive versus negative reinforcement from smoking. Pharmacol Biochem Behav 103:710-6
Du, Fei; Cooper, Alissa; Lukas, Scott E et al. (2013) Creatine kinase and ATP synthase reaction rates in human frontal lobe measured by ýýýýP magnetization transfer spectroscopy at 4T. Magn Reson Imaging 31:102-8
Tong, Yunjie; Hocke, Lia M; Nickerson, Lisa D et al. (2013) Evaluating the effects of systemic low frequency oscillations measured in the periphery on the independent component analysis results of resting state networks. Neuroimage 76:202-15
Bracken, Bethany K; Rouse, Elizabeth D; Renshaw, Perry F et al. (2013) T2 relaxation effects on apparent N-acetylaspartate concentration in proton magnetic resonance studies of schizophrenia. Psychiatry Res 213:142-53

Showing the most recent 10 out of 35 publications