As the breadth and depth of multimodal neuroimaging rapidly expands, there is an important need to train individuals on how use the technology to better detect, understand, develop new medications, track and prevent drug abuse. Sophisticated MRI, PET, EEG and Near Infrared Spectroscopy (NIRS) techniques can be used to explore the neurobiological bases of drug abuse and dependence. This is a proposal to continue a T32 Institutional postdoctoral Training Program to fill an important training need in the field. The key elements of this Training Program include: two locations (McLean Hospital and MGH);participation by multiple departments from basic science to clinical treatment units;availability of training in several imaging modalities including MR, PET, EEG, NIRS;clinical and preclinical training opportunities with integrated translational research opportunities;rich breadh of NIH funded projects to support the trainees'research;group of well-seasoned mentors who have been working together for the past 9 years of this program;option of four well-defined training tracks including: 1) Technology &Instrumentation, 2) Clinical-Basic, 3) Clinical-Treatment and 4) Translational;well-designed 2-3 year training plans that integrate coursework, responsible conduct of research, lab rotations, paper &grant writing experience and independent research;very successful track record of trainees'securing independent funding upon graduation from the program;successful rate of trainee publications;and extensive institutional support for the program as evidenced by significant upgrades to our 3T and 4T clinical scanners and the addition of a 9.4T animal scanner. Over the past 9 years we have developed and maintained an integrated, multidisciplinary Drug Abuse and Brain Imaging Training Program (DABITP) that currently supports 4 postdoctoral slots;we propose to increase the number of trainees to six slots because the program is consistently full and we have expanded to include the Martinos Center for Biomedical Imaging (at MGH), which brings combined MR-PET imaging training to the program and four new training laboratories at McLean Hospital. The combination of didactic training in brain imaging and psychopharmacology with practical applications in a variety of highly successful research laboratories provides our trainees with the skills to utilize a broad range of brain imaging techniques as they embark on the next decade of research on the addicted brain.

Public Health Relevance

Sophisticated brain imaging techniques are more frequently being used to better detect, understand, develop new medications, track and prevent drug abuse. Over the past 9 years we have built and maintained an integrated, multidisciplinary Drug Abuse and Brain Imaging Training Program (DABITP) that currently supports 4 postdoctoral slots to train individuals how to merge imaging technologies with basic and applied clinical research and translational models of drug abuse in order to meet these important needs. The extensive breadth of credentials of the mentors offers the trainees the best opportunity to learn to apply these skills in order to further our understanding of the neurobiological bases of the addicted brain.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZDA1-EXL-T (13))
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Kautz, Mary A
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Mclean Hospital Coroporation
United States
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Dias, N R; Peechatka, A L; Janes, A C (2016) Insula reactivity to negative stimuli is associated with daily cigarette use: A preliminary investigation using the Human Connectome Database. Drug Alcohol Depend 159:277-80
Wang, Changning; Placzek, Michael S; Van de Bittner, Genevieve C et al. (2016) A Novel Radiotracer for Imaging Monoacylglycerol Lipase in the Brain Using Positron Emission Tomography. ACS Chem Neurosci 7:484-9
Stricker, Nikki H; Salat, David H; Kuhn, Taylor P et al. (2016) Mild Cognitive Impairment is Associated With White Matter Integrity Changes in Late-Myelinating Regions Within the Corpus Callosum. Am J Alzheimers Dis Other Demen 31:68-75
Copersino, Marc L; Price, Jenessa S; Frost, Katherine H et al. (2016) Default Mode Network Functional Reorganization During Early Abstinence in Polysubstance-Using Emerging Adults Treated for Opioid Dependence. J Neuropsychiatry Clin Neurosci :appineuropsych15090240
Puhl, Matthew D; Mintzopoulos, Dionyssios; Jensen, J Eric et al. (2015) In vivo magnetic resonance studies reveal neuroanatomical and neurochemical abnormalities in the serine racemase knockout mouse model of schizophrenia. Neurobiol Dis 73:269-74
Price, Jenessa S; McQueeny, Tim; Shollenbarger, Skyler et al. (2015) Effects of marijuana use on prefrontal and parietal volumes and cognition in emerging adults. Psychopharmacology (Berl) 232:2939-50
Padula, Claudia B; McQueeny, Tim; Lisdahl, Krista M et al. (2015) Craving is associated with amygdala volumes in adolescent marijuana users during abstinence. Am J Drug Alcohol Abuse 41:127-32
Placzek, Michael S; Van de Bittner, Genevieve C; Wey, Hsiao-Ying et al. (2015) Immediate and Persistent Effects of Salvinorin A on the Kappa Opioid Receptor in Rodents, Monitored In Vivo with PET. Neuropsychopharmacology 40:2865-72
Baskin-Sommers, Arielle R; Foti, Dan (2015) Abnormal reward functioning across substance use disorders and major depressive disorder: Considering reward as a transdiagnostic mechanism. Int J Psychophysiol :
Lee, Hong Geun; Milner, Phillip J; Placzek, Michael S et al. (2015) Virtually instantaneous, room-temperature [(11)C]-cyanation using biaryl phosphine Pd(0) complexes. J Am Chem Soc 137:648-51

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