This proposal is seeking continued support, via an institutional training grant, for a training program for pre- and postdoctoral fellows who will pursue research careers that focus on the study of genetic influences on substance abuse. The IBG faculty is distinguished and active in research and IBG scientists have actively pursued studies of genetic influences on substance abuse for over 45 years. Major substance abuse-related research projects are now in progress in both human and animal behavior genetics. The application of biometrical, statistical, and quantitative genetic techniques, together with bioinformatics, genome-wide analyses and next generation sequencing, and epigenetics, is providing real advances in our understanding. Neurochemical, neuropharmacological, neurophysiological, and molecular genetic studies, are providing an understanding of gene function related to behavior. Major research projects are now in progress in both human and animal behavior genetics, including large scale national collaborative studies amassing DNA repositories and rich phenotypic data sets available for studies of substance abuse. Facilities are available for genotype assay, including genome-wide assays, gene function and expression studies, and behavioral, biochemical, and neurophysiological studies. Funds are requested to support 4 predoctoral and 2 postdoctoral trainees. Predoctoral trainees receive doctorate degrees from a cooperating academic unit and certification in behavior genetics. Academic requirements in the training program include training in behavior genetics, quantitative and biometrical genetics, theoretical and computer-based statistics, molecular genetics, neuroscience, bioinformatics and genomics, responsible conduct of research, and courses on behavioral and clinical phenotypes. Additional requirements vary according to the degree granting academic unit. Research experience is an integral part of training. Postdoctoral trainees also pursue a formalized program that emphasizes individual research as well as competence in molecular and quantitative behavior genetics. Other activities in preparation for research careers in substance abuse include: supervision of students and/or technicians, hosting of seminar speakers, guest lecturing, a weekly journal club, and mandatory training in the responsible conduct of research and the development of individual professional plans.

Public Health Relevance

This proposal is to train scientists who will be able to contribute significantly to our understanding of genetic contributions to the vulnerability to develop substance abuse. This understanding will lead to new approaches to the prevention and alleviation of substance abuse.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Institutional National Research Service Award (T32)
Project #
2T32DA017637-11
Application #
8666480
Study Section
Special Emphasis Panel (ZDA1)
Program Officer
Gordon, Harold
Project Start
2004-07-01
Project End
2019-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
11
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Colorado at Boulder
Department
Genetics
Type
Graduate Schools
DUNS #
City
Boulder
State
CO
Country
United States
Zip Code
80303
Silventoinen, Karri; Jelenkovic, Aline; Sund, Reijo et al. (2017) Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region: an individual-based pooled analysis of 40 twin cohorts. Am J Clin Nutr 106:457-466
Silventoinen, Karri; Jelenkovic, Aline; Latvala, Antti et al. (2017) Education in Twins and Their Parents Across Birth Cohorts Over 100 years: An Individual-Level Pooled Analysis of 42-Twin Cohorts. Twin Res Hum Genet 20:395-405
Bogl, Leonie H; Jelenkovic, Aline; Vuoksimaa, Eero et al. (2017) Does the sex of one's co-twin affect height and BMI in adulthood? A study of dizygotic adult twins from 31 cohorts. Biol Sex Differ 8:14
Jelenkovic, Aline; Yokoyama, Yoshie; Sund, Reijo et al. (2017) Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project. Int J Epidemiol 46:1488-1498
Demmitt, Brittany A; Corley, Robin P; Huibregtse, Brooke M et al. (2017) Genetic influences on the human oral microbiome. BMC Genomics 18:659
Jelenkovic, Aline; Hur, Yoon-Mi; Sund, Reijo et al. (2016) Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994. Elife 5:
Darlington, T M; McCarthy, R D; Cox, R J et al. (2016) Voluntary wheel running reduces voluntary consumption of ethanol in mice: identification of candidate genes through striatal gene expression profiling. Genes Brain Behav 15:474-90
Huibregtse, Brooke M; Corley, Robin P; Wadsworth, Sally J et al. (2016) A Longitudinal Adoption Study of Substance Use Behavior in Adolescence. Twin Res Hum Genet 19:330-40
Schwantes-An, Tae-Hwi; Zhang, Juan; Chen, Li-Shiun et al. (2016) Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts. Behav Genet 46:151-69
Jelenkovic, Aline; Sund, Reijo; Hur, Yoon-Mi et al. (2016) Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts. Sci Rep 6:28496

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