The purpose of this application is to establish an integrative predoctoral training program in the neuroscience of drug abuse at Indiana University.
Research aim ed at the problem of drug abuse has seen remarkable advances in recent years, driven in large part by a rapidly expanding arsenal of technological innovations at all levels of analysis from ion channel, proteins to human brain mapping. But as the science becomes increasingly complex and specialized, there is a growing danger that opportunities for integration and interaction across disciplines will be lost. Narrowly focused researchers cannot produce the well-rounded scientists the field needs - scientists who have the flexibility to respond to changing techniques and paradigms and who can understand and appreciate the multi-faceted problem of drug abuse. If the expanding research knowledge base is to lead to effective prevention and treatment strategies, the time has come to put a translational perspective on research training. To meet this need, we have assembled a dedicated group of faculty trainers drawn from the Program in Neuroscience and the Department of Psychological and Brain Sciences. This group, which has, a strong and longstanding tradition of collaboration on issues directly relevant to drug abuse, includes senior and junior investigators, molecular neurobiologists and cognitive neuroscientists, and animal behaviorists and clinical scientists. Working together in a state-or-the-art research environment, this group has access to a pool of highly talented trainees motivated to become the next generation of drug abuse researchers. The proposed training program involves trainees in three key components: integrative course work, translational research training, and professional skills development. Course work covers basic neuro- and psychopharmacology, provides an integrative view of biobehavioral processes in substance use disorders, and concludes with an overall perspective on the translation of theoretical and empirical knowledge as it applies to different experimental approaches. Research is guided by a mentor in cellular, systems, cognitive, or clinical neuroscience interacting with a co-mentor representing a different but complimentary level of analysis. This integrative approach is reinforced through discussion groups, attendance at colloquia, and participation at national meetings. Trainees also learn to develop skills in grant writing, manuscript preparation, and teaching. In short, a combination of course work and research training aimed at integrating and translating bench and bedside approaches will create scientists well prepared for the next decade of research on the addicted brain.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Institutional National Research Service Award (T32)
Project #
5T32DA024628-05
Application #
8289570
Study Section
Special Emphasis Panel (ZDA1-EXL-T (04))
Program Officer
Babecki, Beth
Project Start
2008-07-01
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2014-06-30
Support Year
5
Fiscal Year
2012
Total Cost
$181,642
Indirect Cost
$8,714
Name
Indiana University Bloomington
Department
Type
Organized Research Units
DUNS #
006046700
City
Bloomington
State
IN
Country
United States
Zip Code
47401
Panoz-Brown, Danielle; Iyer, Vishakh; Carey, Lawrence M et al. (2018) Replay of Episodic Memories in the Rat. Curr Biol 28:1628-1634.e7
Leishman, Emma; Manchanda, Meera; Thelen, Rachel et al. (2018) Cannabidiol's Upregulation of N-acyl Ethanolamines in the Central Nervous System Requires N-acyl Phosphatidyl Ethanolamine-Specific Phospholipase D. Cannabis Cannabinoid Res 3:228-241
Bolbecker, Amanda R; Apthorp, Deborah; Martin, Ashley Schnakenberg et al. (2018) Disturbances of postural sway components in cannabis users. Drug Alcohol Depend 190:54-61
Slivicki, Richard A; Xu, Zhili; Kulkarni, Pushkar M et al. (2018) Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence. Biol Psychiatry 84:722-733
Schnakenberg Martin, Ashley M; O?Donnell, Brian F; Millward, James B et al. (2017) Acute Phencyclidine Alters Neural Oscillations Evoked by Tones in the Auditory Cortex of Rats. Neuropsychobiology 75:53-62
Li, Ai-Ling; Carey, Lawrence M; Mackie, Ken et al. (2017) Cannabinoid CB2 Agonist GW405833 Suppresses Inflammatory and Neuropathic Pain through a CB1 Mechanism that is Independent of CB2 Receptors in Mice. J Pharmacol Exp Ther 362:296-305
Carey, Lawrence M; Gutierrez, Tannia; Deng, Liting et al. (2017) Inflammatory and Neuropathic Nociception is Preserved in GPR55 Knockout Mice. Sci Rep 7:944
Smith, Alexandra E; Slivicki, Richard A; Hohmann, Andrea G et al. (2017) The chemotherapeutic agent paclitaxel selectively impairs learning while sparing source memory and spatial memory. Behav Brain Res 320:48-57
Panoz-Brown, Danielle; Carey, Lawrence M; Smith, Alexandra E et al. (2017) The chemotherapeutic agent paclitaxel selectively impairs reversal learning while sparing prior learning, new learning and episodic memory. Neurobiol Learn Mem 144:259-270
Leishman, Emma; Kunkler, Phillip E; Manchanda, Meera et al. (2017) Environmental Toxin Acrolein Alters Levels of Endogenous Lipids, Including TRP Agonists: A Potential Mechanism for Headache Driven by TRPA1 Activation. Neurobiol Pain 1:28-36

Showing the most recent 10 out of 26 publications