Addictions and the associated public health problems of HIV transmission, crime and violence, exact a severe toll on our nation, costing billions annually in health care, lost productivity, and incarceration. As there have been rapid advances in neuroscience and genetics in the past two decades, we need to speed the 'forward'translation of this knowledge into more effective clinical treatments for the addictions. Conversely, for addiction treatments with some known efficacy, we can now apply new neuroscience and genetic tools in 'backward-translation'-- e.g., finding why a treatment works well for some individuals, yet not at all for others. To help meet the need for skilled translatioal researchers, this application proposes a continuation of our T32 Translational Addiction Research Fellowship for pre- and post-doctoral trainees at the University of Pennsylvania. The training program will make explicit a long-standing translational tradition at Penn, integrating clinical and basic research strengths to create trainees, whether clinical or preclinical, Ph.D.'s or M.D.s, who will be able to accelerate addiction science in the next decade. The emphasis on translation is reflected at each level of the program - through the Co-PIs (clinical and basic, Drs. Childress and Pierce), the internal and external advisory board members, the formal didactics, the """"""""dual"""""""" mentoring (each trainee will have both a clinical and preclinical mentor), and in the focus of trainees'mentored research projects. The translational emphasis of the program is driven by the recognition that addictions are complex disorders, multi-determined by interaction of genetic vulnerabilities, exposure to drug, and a host of modulating (e.g., early trauma, stress, cultural norms) influences. Trainees will thus be offered state-of-the-art knowledge about these interacting determinants through a didactic series specific to the program, and through mentored projects that may range from molecular and genetic studies, to brain systems (neuroscience and neuroimaging), to clinical treatment trials, and drug policy. This wide range of choices is enabled by the long history of excellence in addiction research at the University, reflected in the several academic research Centers (Penn-VA Addiction Research Center~ Translational Research Laboratories/CNB~ Center for Aids Research~ Transdisciplinary Tobacco Use Research Center~ Treatment Research Institute) and laboratories (Lucki lab, Mackler lab) offering skilled, successful mentors to the Fellowship. Mentored research also takes place within several affiliated treatment settings (VA, Presby-Penn, NIDA CTN sites, community methadone clinics, and mobile HIV Prevention units), critical for translating new research findings into the 'real world'. Public Health Relevance: The addictions are complex and expensive public health problems for which we need more effective treatments. The proposed T32 Translational Addiction Research Fellowship will give trainees the framework, and the skills, to speed the development of effective addiction treatments - with concomitant benefit for the addiction-linked public health problems of violence, crime and HIV/AIDs.

Public Health Relevance

The addictions are complex and expensive public health problems for which we need more effective treatments. The proposed T32 Translational Addiction Research Fellowship will give trainees the framework, and the skills, to speed the development of effective addiction treatments - with concomitant benefit for the addiction-linked public health problems of violence, crime and HIV/AIDs. PUBLIC HEALTH RELEVANCE: The proposed continuation of a recently-funded T32 Translational Addiction Research Fellowship at the University of Pennsylvania will give 4 pre-doctoral and 4 post-doctoral trainees the framework, and the skills, to speed the next generation of effective addiction treatments - with concomitant benefit for the addiction-linked public health problems of violence, crime and HIV/AIDs.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Institutional National Research Service Award (T32)
Project #
2T32DA028874-03A1
Application #
8475315
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Kautz, Mary A
Project Start
2010-07-01
Project End
2018-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
3
Fiscal Year
2013
Total Cost
$426,007
Indirect Cost
$26,015
Name
University of Pennsylvania
Department
Psychiatry
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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Schmidt, Heath D; Mietlicki-Baase, Elizabeth G; Ige, Kelsey Y et al. (2016) Glucagon-Like Peptide-1 Receptor Activation in the Ventral Tegmental Area Decreases the Reinforcing Efficacy of Cocaine. Neuropsychopharmacology 41:1917-28
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Hart, Amy B; Kranzler, Henry R (2015) Alcohol Dependence Genetics: Lessons Learned From Genome-Wide Association Studies (GWAS) and Post-GWAS Analyses. Alcohol Clin Exp Res 39:1312-27
Denis, Cécile M; Gelernter, Joel; Hart, Amy B et al. (2015) Inter-observer reliability of DSM-5 substance use disorders. Drug Alcohol Depend 153:229-35
Guercio, Leonardo A; Schmidt, Heath D; Pierce, R Christopher (2015) Deep brain stimulation of the nucleus accumbens shell attenuates cue-induced reinstatement of both cocaine and sucrose seeking in rats. Behav Brain Res 281:125-30
Yohn, Nicole L; Turner, Jill R; Blendy, Julie A (2014) Activation of α4β2*/α6β2* nicotinic receptors alleviates anxiety during nicotine withdrawal without upregulating nicotinic receptors. J Pharmacol Exp Ther 349:348-54
Turner, Jill R; Ecke, Laurel E; Briand, Lisa A et al. (2013) Cocaine-related behaviors in mice with deficient gliotransmission. Psychopharmacology (Berl) 226:167-76
Vassoler, Fair M; White, Samantha L; Schmidt, Heath D et al. (2013) Epigenetic inheritance of a cocaine-resistance phenotype. Nat Neurosci 16:42-7

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