This application requests continued support for a research training program in Otolaryngology to provide two-year basic and clinical research training opportunities for physicians pursuing an academic career in Otolaryngology-Head and Neck Surgery. Research training in neurosciences, molecular genetics, molecular biology, and epidemiology promotes the long- term goal of increasing the number and quality of independent clinical investigators studying the underlying mechanisms, diagnostic criteria, and therapeutic approaches of the impaired auditory and other communicative systems. A multidisciplinary educational environment is created through the interaction of over thirty clinicians and basic scientists from the departments and programs of Otolaryngology-Head and Neck Surgery, Hearing Sciences, Speech Science, Neuroscience, Internal Medicine, Pediatric Genetics, Microbiology, Molecular Biology, and The College of Public Health. A wide assortment of research training opportunities are available, ranging from basic research in electrophysiology and molecular biology of the auditory system, neuroanatomy, neurolaryngology, molecular genetics of deafness, and molecular biology of craniofacial deformities to clinical investigations involving epidemiologic study of hearing loss, craniofacial deformities, head and neck cancer, speech disorders, and clinical trials study of hearing loss, craniofacial deformities, head and neck cancer, speech disorders and clinical trials methodology. Trainees will be enrolled in didactic courses in their area of interest throughout the two-year training period. The application requests two postgraduate training positions a year (ten over five years) for physicians completing at least one year of clinical training. Trainees will devote 100% of their effort to research training for two consecutive years, to be followed by a four-year clinical residency in Otolaryngology-Head and Neck Surgery. Trainees will have two additional 3-month research blocks during the PGY3 and PGY4 years, supported by the Department of Otolaryngology-Head and Neck Surgery, providing at least 2.5 years of an intensive research training experience. The proposed research training program will expand the research training opportunities available to future academic otolaryngologists, foster interaction among clinical and basic scientists, and provide physicians with tools to become comprehensive independent clinician-scientists.

Public Health Relevance

Training physician scientists in communicative disorders basic research will expand translational research that will have an impact on delivery of care, as well as advance the treatment of communicative disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Institutional National Research Service Award (T32)
Project #
2T32DC000040-21
Application #
8666139
Study Section
Special Emphasis Panel (ZDC1)
Program Officer
Sklare, Dan
Project Start
1993-07-01
Project End
2019-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
21
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Iowa
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Truong, Kristy; Ahmad, Iram; Jason Clark, J et al. (2018) Nf2 Mutation in Schwann Cells Delays Functional Neural Recovery Following Injury. Neuroscience 374:205-213
Xu, Linjing; Seline, Alison E; Leigh, Braden et al. (2018) Photopolymerized Microfeatures Guide Adult Spiral Ganglion and Dorsal Root Ganglion Neurite Growth. Otol Neurotol 39:119-126
Yoshimura, Hidekane; Shibata, Seiji B; Ranum, Paul T et al. (2018) Enhanced viral-mediated cochlear gene delivery in adult mice by combining canal fenestration with round window membrane inoculation. Sci Rep 8:2980
Roche, Joseph P; Goates, Andrew J; Hasan, David M et al. (2017) Treatment of Lateral Skull Base and Posterior Cranial Fossa Lesions Utilizing the Extended Middle Cranial Fossa Approach. Otol Neurotol 38:742-750
Thompson, Nicholas J; Roche, Joseph P; Schularick, Nathan M et al. (2017) Reconstruction Outcomes Following Lateral Skull Base Resection. Otol Neurotol 38:264-271
Leigh, Braden L; Truong, Kristy; Bartholomew, Reid et al. (2017) Tuning Surface and Topographical Features to Investigate Competitive Guidance of Spiral Ganglion Neurons. ACS Appl Mater Interfaces 9:31488-31496
Shearer, A Eliot; Eppsteiner, Robert W; Frees, Kathy et al. (2017) Genetic variants in the peripheral auditory system significantly affect adult cochlear implant performance. Hear Res 348:138-142
Leigh, Braden L; Cheng, Elise; Xu, Linjing et al. (2017) Photopolymerizable Zwitterionic Polymer Patterns Control Cell Adhesion and Guide Neural Growth. Biomacromolecules 18:2389-2401
Cheng, Elise; Hansen, Marlan R (2016) Schwannomas provide insight into the role of p75(NTR) and merlin in Schwann cells following nerve injury and during regeneration. Neural Regen Res 11:73-4
Cheng, Elise L; Leigh, Braden; Guymon, C Allan et al. (2016) Quantifying Spiral Ganglion Neurite and Schwann Behavior on Micropatterned Polymer Substrates. Methods Mol Biol 1427:305-18

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