This proposal requests funds for continuation of a training program in fundamental chemosensory research at Florida State University (FSU). Four positions at the predoctoral level and two positions at the postdoctoral level are requested. The FSU Neuroscience Program, within which this Chemosensory Training Program operates, has a long history of high quality training and research in sensory systems, especially the chemosensory systems. The training program at FSU is firmly focused on the search for fundamental scientific knowledge, on which all applied and clinical understanding must be based. It is characterized by a diversity of research perspectives among the associated faculty and a diversity of research methodologies even within a single investigator's laboratory. Thus, the program affords pre- and post-doctoral trainees with unusual opportunities to explore and master many research approaches to important questions about chemosensory function. And to do so under the guidance of well-respected faculty used to productive collaborations. The research approaches represented in the Program include electrophysiological, molecular, anatomical, and quantitative behavioral analysis. The research support facilities are also exceptional;for example, molecular biological, electronics, computer, electron/ confocal microscopy and photography facilities, with professional staff, are all available to program members and trainees. A highly distinguished new faculty member has joined the training program since the last competitive renewal and almost all program faculties now have new laboratory space in new buildings. The notable features of this program include its distinguished history and excellent faculty, its focus on basis mechanisms studied in depth and breadth, and the outstanding technical facilities available. Trainees have an opportunity to acquire the perspective that is necessary for success in pushing out the boundaries of knowledge, and advice and assistance in obtaining the skills necessary for a career in externally funded productive research.

Public Health Relevance

The training program at FSU is focused on the search for fundamental scientific knowledge, on which all applied and clinical understanding must be based. The program affords pre- and post-doctoral trainees with unusual opportunities to explore and master many research approaches to important questions about taste and smell function, whose loss involves devastating loss of quality of life, and whose central brain circuits are important in eating disorders, obesity, diabetes and hypertension;and perhaps other neurological disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Institutional National Research Service Award (T32)
Project #
2T32DC000044-16
Application #
7855996
Study Section
Special Emphasis Panel (ZDC1-SRB-L (45))
Program Officer
Sklare, Dan
Project Start
1995-07-01
Project End
2015-06-30
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
16
Fiscal Year
2010
Total Cost
$207,605
Indirect Cost
Name
Florida State University
Department
Type
Schools of Arts and Sciences
DUNS #
790877419
City
Tallahassee
State
FL
Country
United States
Zip Code
32306
Schwartz, Austin B; Kapur, Anshika; Wang, Wentao et al. (2017) Margatoxin-bound quantum dots as a novel inhibitor of the voltage-gated ion channel Kv1.3. J Neurochem 140:404-420
Bell, Genevieve A; Fadool, Debra Ann (2017) Awake, long-term intranasal insulin treatment does not affect object memory, odor discrimination, or reversal learning in mice. Physiol Behav 174:104-113
Schier, Lindsey A; Spector, Alan C (2016) Behavioral Evidence for More than One Taste Signaling Pathway for Sugars in Rats. J Neurosci 36:113-24
Schier, Lindsey A; Blonde, Ginger D; Spector, Alan C (2016) Bilateral lesions in a specific subregion of posterior insular cortex impair conditioned taste aversion expression in rats. J Comp Neurol 524:54-73
Westberry, Jenne M; Meredith, Michael (2016) GABAergic mechanisms contributing to categorical amygdala responses to chemosensory signals. Neuroscience 331:186-96
Kovach, Christopher P; Al Koborssy, Dolly; Huang, Zhenbo et al. (2016) Mitochondrial Ultrastructure and Glucose Signaling Pathways Attributed to the Kv1.3 Ion Channel. Front Physiol 7:178
Blonde, Ginger D; Bales, Michelle B; Spector, Alan C (2015) Extensive lesions in rat insular cortex significantly disrupt taste sensitivity to NaCl and KCl and slow salt discrimination learning. PLoS One 10:e0117515
Torregrossa, A-M; Loney, G C; Smith, J C et al. (2015) Examination of the perception of sweet- and bitter-like taste qualities in sucralose preferring and avoiding rats. Physiol Behav 140:96-103
Torregrossa, Ann-Marie; Nikonova, Larissa; Bales, Michelle B et al. (2014) Induction of salivary proteins modifies measures of both orosensory and postingestive feedback during exposure to a tannic acid diet. PLoS One 9:e105232
Kimbrough, Adam; Biggs, Lindsey M (2014) BDNF signaling potentiates transmission of information from the basolateral amygdala to infralimbic prefrontal cortex during conditioned taste aversion extinction. J Neurosci 34:12617-8

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