Rapid introduction of basic science discoveries into clinical fields requires close collaboration of basic and clinician scientists. Accomplishing this n otolaryngology requires a multidisciplinary approach to better define and treat the many disorders of the head and neck. Residency programs today offer limited research training for otolaryngologists, but few become independent investigators. In contrast, the basic sciences postdoctoral training offers little exposure to the clinical setting, making translational research difficult. The goal of this application is to provide research training in otolaryngology and its related sciences. Support is requested for in-depth training for 1) residents, 2) postdoctoral fellows, 3) predoctoral students and 4) short-term medical students. All trainees will receive an interactive basic research experience with ongoing exposure to and interaction of trainees in the clinical setting through conferences and courses. The pre- and postdoctoral trainees will have a 24-month block of training. Research training for MDs will begin in medical school with students doing short-term (3-month) projects and continue through the residency program with a 2-year block midway through the clinical training. One resident will be admitted each year into this research track. Early introduction and continued research involvement throughout the residency will increase our ability to attract academically oriented faculty members into the field, with backgrounds to become independent investigators. This cross-field exposure will enhance the experience for trainees and promote clinical and basic science interactions as a faculty. A major strength of the program is drawing members of the faculty from a wide variety of departments of the School of Medicine and across the UC campuses involved in otolaryngology related research. This will enhance collaborative efforts in related fields of hearing, balance, smell, taste, speech, language and head and neck cancer. All faculty members have primary or secondary appointments within the Department of Otolaryngology, creating an ideal environment for translational research between basic and clinician scientists. Through this multidisciplinary approach to research training for different levels of trainees from a variety of fields, recruitment and retention of a research-oriented academic faculty involved in research into disorders of the ears, nose and throat will be increased.

Public Health Relevance

The goal of this application is to provide research training in otolaryngology and its related sciences. Support is requested for in-depth training for 1) residents, 2) postdoctoral fellows, 3) predoctoral students and 4) short- term medical students.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Institutional National Research Service Award (T32)
Project #
5T32DC012280-02
Application #
8662229
Study Section
Special Emphasis Panel (ZDC1)
Program Officer
Sklare, Dan
Project Start
2013-07-01
Project End
2018-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
2
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
City
Aurora
State
CO
Country
United States
Zip Code
80045
Banakis Hartl, Renee M; Mattingly, Jameson K; Greene, Nathaniel T et al. (2016) A Preliminary Investigation of the Air-Bone Gap: Changes in Intracochlear Sound Pressure With Air- and Bone-conducted Stimuli After Cochlear Implantation. Otol Neurotol 37:1291-9
Greene, Nathaniel T; Mattingly, Jameson K; Banakis Hartl, Renee M et al. (2016) Intracochlear Pressure Transients During Cochlear Implant Electrode Insertion. Otol Neurotol 37:1541-1548
Sharma, Anu; Glick, Hannah; Campbell, Julia et al. (2016) Cortical Plasticity and Reorganization in Pediatric Single-sided Deafness Pre- and Postcochlear Implantation: A Case Study. Otol Neurotol 37:e26-34
Sharma, Anu; Glick, Hannah (2016) Cross-Modal Re-Organization in Clinical Populations with Hearing Loss. Brain Sci 6:
Greene, Nathaniel T; Mattingly, Jameson K; Jenkins, Herman A et al. (2015) Cochlear Implant Electrode Effect on Sound Energy Transfer Within the Cochlea During Acoustic Stimulation. Otol Neurotol 36:1554-61
Brown, Andrew D; Beemer, Brianne T; Greene, Nathaniel T et al. (2015) Effects of Active and Passive Hearing Protection Devices on Sound Source Localization, Speech Recognition, and Tone Detection. PLoS One 10:e0136568
Mattingly, Jameson K; Greene, Nathaniel T; Jenkins, Herman A et al. (2015) Effects of Skin Thickness on Cochlear Input Signal Using Transcutaneous Bone Conduction Implants. Otol Neurotol 36:1403-11
Sharma, Anu; Glick, Hannah; Deeves, Emily et al. (2015) The P1 biomarker for assessing cortical maturation in pediatric hearing loss: a review. Otorinolaringologia 65:103-114
Tizzano, Marco; Grigereit, Laura; Shultz, Nicole et al. (2015) Immunohistochemical Analysis of Human Vallate Taste Buds. Chem Senses 40:655-60
Greene, Nathaniel T; Anbuhl, Kelsey L; Williams, Whitney et al. (2014) The acoustical cues to sound location in the guinea pig (Cavia porcellus). Hear Res 316:1-15

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