This proposed research training program is a competing renewal of an existing T32 research training grant at the University of Texas Health Science Center at San Antonio (UTHSCSA). The Craniofacial Oral-biology Student Training in Academic Research (COSTAR), which is submitted in response to announcement PAR-05-101, provides a comprehensive research training environment spanning basic science to clinical and translational research training. The purpose of COSTAR is to train a cadre of highly skilled, interactive scientists who can successfully address the new opportunities in dental, oral, and craniofacial research and become part of the future academic faculty in US dental schools. COSTAR will offer three complementary training tracks: 1) DDS/PhD program, 2) PhD program, and c) Postdoctoral research fellowships. The training is provided by a highly selected, research intensive and successful Program faculty from multiple departments in the Dental, Medical, and Graduate Schools at UTHSCSA, thus creating a strong multi- and inter-disciplinary training environment. Collectively, this Program Faculty has trained a large number of students at all levels of the COSTAR program. Based on experiences gained in the first grant period, COSTAR has been focused towards the successful training of students in long-term advanced degree programs and postdoctoral fellows. Adding a new postdoctoral research training opportunity in clinical sciences will adapt the program to UTHSCSA clinical research initiatives and aligns COSTAR with national priorities as outlined in the NIH Roadmap Initiative. Over the grant period, COSTAR will offer training to highly motivated and dedicated trainees in oral biology research for a total of 13 DDS/PhD students, 15 PhD students, and 9 postdoctoral fellows in basic or clinical research. The trainees will participate in core courses, COSTAR and Dental School research seminars, journal clubs, COSTAR training track meetings, and present their research at local and national scientific meetings. Trainee independence will be encouraged by successful submission of applications for individual awards. The COSTAR Leadership Council has extensive experience in administering research training and benefits from strong institutional support. Thus, COSTAR will provide the optimal environment for research training of new scientists reflected by the long-term success in academia of former trainees at the UTHSCSA.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Institutional National Research Service Award (T32)
Project #
5T32DE014318-10
Application #
8084085
Study Section
Special Emphasis Panel (ZDE1-LK (22))
Program Officer
King, Lynn M
Project Start
2001-07-01
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
10
Fiscal Year
2011
Total Cost
$653,343
Indirect Cost
Name
University of Texas Health Science Center San Antonio
Department
Dentistry
Type
Schools of Dentistry
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Brackley, Allison Doyle; Sarrami, Shayda; Gomez, Ruben et al. (2017) Identification of a signaling cascade that maintains constitutive ?-opioid receptor incompetence in peripheral sensory neurons. J Biol Chem 292:8762-8772
Pham, Cong-Dat; Smith, Charles E; Hu, Yuanyuan et al. (2017) Endocytosis and Enamel Formation. Front Physiol 8:529
Hambright, Heather Graham; Ghosh, Rita (2017) Autophagy: In the cROSshairs of cancer. Biochem Pharmacol 126:13-22
Rohena, Cristina C; Risinger, April L; Devambatla, Ravi Kumar Vyas et al. (2016) Janus Compounds, 5-Chloro-N?-methyl-N?-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects. Molecules 21:
Blanchette, Krystle A; Shenoy, Anukul T; Milner 2nd, Jeffrey et al. (2016) Neuraminidase A-Exposed Galactose Promotes Streptococcus pneumoniae Biofilm Formation during Colonization. Infect Immun 84:2922-32
Mishra, Anuja; Qiu, Zhifang; Farnsworth, Steven L et al. (2016) Induced Pluripotent Stem Cells from Nonhuman Primates. Methods Mol Biol 1357:183-93
Marinkovic, Milos; Block, Travis J; Rakian, Rubie et al. (2016) One size does not fit all: developing a cell-specific niche for in vitro study of cell behavior. Matrix Biol 52-54:426-441
Sullivan, Laura C; Chavera, Teresa S; Jamshidi, Raehannah J et al. (2016) Constitutive Desensitization of Opioid Receptors in Peripheral Sensory Neurons. J Pharmacol Exp Ther 359:411-419
Jamshidi, Raehannah J; Sullivan, Laura C; Jacobs, Blaine A et al. (2016) Long-Term Reduction of Kappa Opioid Receptor Function by the Biased Ligand, Norbinaltorphimine, Requires c-Jun N-Terminal Kinase Activity and New Protein Synthesis in Peripheral Sensory Neurons. J Pharmacol Exp Ther 359:319-328
Malakhov, A; Wen, J; Zhang, B-X et al. (2016) Rechargeable anticandidal denture material with sustained release in saliva. Oral Dis 22:391-8

Showing the most recent 10 out of 121 publications