The training program in gastroenterology &hepatology at the University of Colorado Denver is committed to preparing highly motivated post-doctoral candidates for successful careers in academic gastroenterology. The purpose of this renewal application is to sustain and expand this program's record of scientific work and accomplishments of the last 34 years. The positive structural changes this program has undergone since the last review have strongly enhanced the research environment and diverse opportunities available to prospective trainees. These include the recruitment of 16 additional faculty members to the division, establishment of the Mucosal Inflammation program (MIP), a move to our new state of the art campus, formation of a divisional research administration group, establishment of a women's health practice, and expansion and strengthening of collaborative ties with other disciplines. Future growth initiatives include active participation in a planned obesity/nutrition center and expansion of both the women's health practice and the MIP. Programmatic improvements since the last review include the formation of a Research and Career Development Committee (RCDC) and a Fellowship Mentorship Monitoring Committee. Both committees are designed and were implemented to improve the quality, diversity and frequency of mentoring from faculty members, as well as to track trainee progress and identify any pitfalls, obstacles, or resource deficits. Specific goals of this project continue to be: 1) Provide a diverse research environment complete with multi-disciplinary resources and mentorship 2) Produce the next generation of academic gastroenterologists with a focus on understanding molecular, physiologic, and immunological processes of gastrointestinal and liver diseases that broadly affect the public. 3) Implementation a successful system to recruit, train, mentor, foster careers, and maintain collaborative relationships with successful academic physicians and scientists.

Public Health Relevance

Pervasive public health concerns specific to gastroenterology and liver diseases include: hepatitis, inflammatory bowel disease, and obesity, among others. The cutting-edge and collaborative research environment this project provides for young investigators is key to finding future clinical solutions for these public health concerns.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
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Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
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Densmore, Christine L
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University of Colorado Denver
Internal Medicine/Medicine
Schools of Medicine
United States
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Wieland, Amanda C; Mettler, Pamela; McDermott, Michael T et al. (2015) Low awareness of nonalcoholic fatty liver disease among patients at high metabolic risk. J Clin Gastroenterol 49:e6-e10
Obuch, Joshua C; Pigott, Courtney M; Ahnen, Dennis J (2015) Sessile serrated polyps: detection, eradication, and prevention of the evil twin. Curr Treat Options Gastroenterol 13:156-70
Wedd, Joel; Bambha, Kiran M; Stotts, Matt et al. (2014) Stage of cirrhosis predicts the risk of liver-related death in patients with low Model for End-Stage Liver Disease scores and cirrhosis awaiting liver transplantation. Liver Transpl 20:1193-201
Wieland, Amanda C; Quallick, Matthew; Truesdale, Aimee et al. (2013) Identifying practice gaps to optimize medical care for patients with nonalcoholic fatty liver disease. Dig Dis Sci 58:2809-16
Mengshol, J A; Golden-Mason, L; Castelblanco, N et al. (2009) Impaired plasmacytoid dendritic cell maturation and differential chemotaxis in chronic hepatitis C virus: associations with antiviral treatment outcomes. Gut 58:964-73
Condino, Adria A; Sondheimer, Judith; Pan, Zhaoxing et al. (2006) Evaluation of gastroesophageal reflux in pediatric patients with asthma using impedance-pH monitoring. J Pediatr 149:216-9
Proctor, Gregory; Jiang, Tao; Iwahashi, Mieko et al. (2006) Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes. Diabetes 55:2502-9
Wyles, David L; Gerber, John G (2005) Antiretroviral drug pharmacokinetics in hepatitis with hepatic dysfunction. Clin Infect Dis 40:174-81
Wyles, David L; Patel, Amita; Madinger, Nancy et al. (2005) Development of herpes simplex virus disease in patients who are receiving cidofovir. Clin Infect Dis 41:676-80
Tardif, Keith D; Waris, Gulam; Siddiqui, Aleem (2005) Hepatitis C virus, ER stress, and oxidative stress. Trends Microbiol 13:159-63

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