This application is a competing renewal application for years 37-41 for this Training Grant in Diabetes and Endocrinology. It was the first, and remains the longest-running, T-32 grant at the University of Pittsburgh School of Medicine. The goals of the application are: A. To attract outstanding MD and PhD postdoctoral trainees with authentic academic interests and potential B. To pair them with similarly outstanding research training faculty to serve as mentors C. To provide a venue for outstanding training and mentoring in diabetes, obesity, bone and mineral, osteoporosis, endocrine epidemiology, as well as basic cellular and molecular endocrinology research D. To eliminate the barriers between clinical, basic and translational research in Endocrinology E. To support the trainee's and mentor's needs in providing this outstanding training F. To provide a supportive and highly enriching didactic environment in which to receive this training G. To help the trainees transition to junior faculty positions H. To adequately protect MD trainees from clinical responsibilities while receiving research training I. To provide opportunities for research training to all members of underrepresented ethnic, disadvantaged and disabled groups J. To provide formal, documented instruction in research integrity, responsible conduct of research as well as all other areas of research conduct and compliance In the last round of funding, the program has shown a strong record of meeting all of these goals, with 58- 74% of graduates in the past 10 years now serving in academic positions, depending on how rigorously "academic" is defined

Public Health Relevance

This Training Grant helps to replenish the supply of academic specialists, both MD and PhD, in topical areas of national health priorities, such as diabetes, obesity, osteoporosis, and women's health. It supports a high quality program, and its quality is continuing to further improve with each year, by every objective measure. It has been successful in training, excellent candidates, with half to three quarters of trainees in the past 10 years remaining in academia.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007052-39
Application #
8284442
Study Section
Special Emphasis Panel (ZDK1-GRB-W (J3))
Program Officer
Castle, Arthur
Project Start
1975-07-01
Project End
2015-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
39
Fiscal Year
2012
Total Cost
$193,462
Indirect Cost
$18,084
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
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Reeves, Valerie L; Trybula, Joy S; Wills, Rachel C et al. (2015) Serum Autotaxin/ENPP2 correlates with insulin resistance in older humans with obesity. Obesity (Silver Spring) 23:2371-6
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Schoiswohl, Gabriele; Stefanovic-Racic, Maja; Menke, Marie N et al. (2015) Impact of Reduced ATGL-Mediated Adipocyte Lipolysis on Obesity-Associated Insulin Resistance and Inflammation in Male Mice. Endocrinology 156:3610-24
Lyons, Sarah K; Becker, Dorothy J; Helgeson, Vicki S (2014) Transfer from pediatric to adult health care: effects on diabetes outcomes. Pediatr Diabetes 15:10-7
Alvarez-Perez, Juan Carlos; Ernst, Sara; Demirci, Cem et al. (2014) Hepatocyte growth factor/c-Met signaling is required for β-cell regeneration. Diabetes 63:216-23
Coen, P M; Hames, K C; Leachman, E M et al. (2013) Reduced skeletal muscle oxidative capacity and elevated ceramide but not diacylglycerol content in severe obesity. Obesity (Silver Spring) 21:2362-71
Lyons, Sarah K; Libman, Ingrid M; Sperling, Mark A (2013) Clinical review: Diabetes in the adolescent: transitional issues. J Clin Endocrinol Metab 98:4639-45

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