This application is a competing renewal application for years 37-41 for this Training Grant in Diabetes and Endocrinology. It was the first, and remains the longest-running, T-32 grant at the University of Pittsburgh School of Medicine. The goals of the application are: A. To attract outstanding MD and PhD postdoctoral trainees with authentic academic interests and potential B. To pair them with similarly outstanding research training faculty to serve as mentors C. To provide a venue for outstanding training and mentoring in diabetes, obesity, bone and mineral, osteoporosis, endocrine epidemiology, as well as basic cellular and molecular endocrinology research D. To eliminate the barriers between clinical, basic and translational research in Endocrinology E. To support the trainee's and mentor's needs in providing this outstanding training F. To provide a supportive and highly enriching didactic environment in which to receive this training G. To help the trainees transition to junior faculty positions H. To adequately protect MD trainees from clinical responsibilities while receiving research training I. To provide opportunities for research training to all members of underrepresented ethnic, disadvantaged and disabled groups J. To provide formal, documented instruction in research integrity, responsible conduct of research as well as all other areas of research conduct and compliance In the last round of funding, the program has shown a strong record of meeting all of these goals, with 58- 74% of graduates in the past 10 years now serving in academic positions, depending on how rigorously "academic" is defined

Public Health Relevance

This Training Grant helps to replenish the supply of academic specialists, both MD and PhD, in topical areas of national health priorities, such as diabetes, obesity, osteoporosis, and women's health. It supports a high quality program, and its quality is continuing to further improve with each year, by every objective measure. It has been successful in training, excellent candidates, with half to three quarters of trainees in the past 10 years remaining in academia.

National Institute of Health (NIH)
Institutional National Research Service Award (T32)
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Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Castle, Arthur
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University of Pittsburgh
Internal Medicine/Medicine
Schools of Medicine
United States
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Lyons, Sarah K; Becker, Dorothy J; Helgeson, Vicki S (2014) Transfer from pediatric to adult health care: effects on diabetes outcomes. Pediatr Diabetes 15:10-7
Alvarez-Perez, Juan Carlos; Ernst, Sara; Demirci, Cem et al. (2014) Hepatocyte growth factor/c-Met signaling is required for *-cell regeneration. Diabetes 63:216-23
Demirci, Cem; Ernst, Sara; Alvarez-Perez, Juan C et al. (2012) Loss of HGF/c-Met signaling in pancreatic ?-cells leads to incomplete maternal ?-cell adaptation and gestational diabetes mellitus. Diabetes 61:1143-52
Karslioglu, Esra; Kleinberger, Jeffrey W; Salim, Fatimah G et al. (2011) cMyc is a principal upstream driver of beta-cell proliferation in rat insulinoma cell lines and is an effective mediator of human beta-cell replication. Mol Endocrinol 25:1760-72
Schopfer, Francisco J; Cole, Marsha P; Groeger, Alison L et al. (2010) Covalent peroxisome proliferator-activated receptor gamma adduction by nitro-fatty acids: selective ligand activity and anti-diabetic signaling actions. J Biol Chem 285:12321-33
Guthalu Kondegowda, Nagesha; Joshi-Gokhale, Sheela; Harb, George et al. (2010) Parathyroid hormone-related protein enhances human ß-cell proliferation and function with associated induction of cyclin-dependent kinase 2 and cyclin E expression. Diabetes 59:3131-8
Borniquel, Sara; Jansson, Emmelie A; Cole, Marsha P et al. (2010) Nitrated oleic acid up-regulates PPARgamma and attenuates experimental inflammatory bowel disease. Free Radic Biol Med 48:499-505
Goodpaster, Bret H; Delany, James P; Otto, Amy D et al. (2010) Effects of diet and physical activity interventions on weight loss and cardiometabolic risk factors in severely obese adults: a randomized trial. JAMA 304:1795-802
Cole, Marsha P; Rudolph, Tanja K; Khoo, Nicholas K H et al. (2009) Nitro-fatty acid inhibition of neointima formation after endoluminal vessel injury. Circ Res 105:965-72
Schopfer, F J; Batthyany, C; Baker, P R S et al. (2009) Detection and quantification of protein adduction by electrophilic fatty acids: mitochondrial generation of fatty acid nitroalkene derivatives. Free Radic Biol Med 46:1250-9

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