This proposal seeks continued support for the Yale research-training program in Diabetes Mellitus and Disorders of Metabolism. This program serves as the core source of support for postdoctoral research training in diabetes and endocrinology at the Yale School of Medicine. A major goal of the program is to provide physician-scientists with the research expertise required to pursue clinical, basic and translational research careers in an academic setting. Physician trainees entering the program will have M.D. or M.D./Ph.D degrees and at least 2-3 years of clinical training in internal medicine or pediatrics. Ph.D. scientists are also recruited into the program since we believe an integrated training experience bringing together adult endocrinologists, pediatric endocrinologists and endocrine scientists is necessary to prepare our trainees to participate in modern multidisciplinary research groups. Trainees are selected based on their aptitude and commitment to a research career. The duration of the training period is three years to ensure an in-depth training experience. The cornerstone of the curriculum is the participation of each trainee in a specific research project under the supervision of a designated preceptor and guided by a progress committee composed of 2-3 other members of the training faculty. Potential projects run the gamut from clinical to basic research in 3 primary areas of emphasis: 1) type 1 diabetes, 2) type 2 diabetes, and 3) bone and mineral metabolism. Within these areas, trainees have the opportunity to work with mentors in several basic science departments as well as those in Pediatrics and Medicine. Close interaction among preceptors and trainees within each programmatic area and within several multidisciplinary and interdepartmental research centers administered within the Endocrine Section further enrich the training experience. Multiple educational opportunities including two degree-granting (MS, PhD) programs are available to trainees through the CTSA-funded Yale Center for Clinical Investigation. Instruction is also provided through organized lectures, research seminars and journal clubs. The application requests an additional training slot per year for a total of 6 stipends. This is based on our decision to fully integrate Yale's pediatric and internal medicine training programs in diabetes and metabolism and, therefore, not to seek renewal of the pediatric T32 (DK63703). It is also based on our ongoing track record of attracting an outstanding applicant pool, the high level of research productivity of our training faculty, the expanded research opportunities provided by our diverse faculty and the continued shortage of physician-scientists in both medicine and pediatrics dedicated to research careers in diabetes and metabolic diseases.

Public Health Relevance

Obesity, diabetes and osteoporosis represent a spectrum of increasingly prevalent metabolic diseases that are responsible for a great burden of suffering and death in the US and throughout the world. Academic endocrine researchers are needed to better understand these disorders and to translate research findings into new therapies. Our training program in diabetes and disorders of metabolism is dedicated to providing young physicians and scientists with the research training necessary to tackle these important health problems.

National Institute of Health (NIH)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Digestive Diseases and Nutrition C Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Yale University
Internal Medicine/Medicine
Schools of Medicine
New Haven
United States
Zip Code
Brewer, Paul Duffield; Habtemichael, Estifanos N; Romenskaia, Irina et al. (2014) Insulin-regulated Glut4 translocation: membrane protein trafficking with six distinctive steps. J Biol Chem 289:17280-98
Belman, Jonathan P; Habtemichael, Estifanos N; Bogan, Jonathan S (2014) A proteolytic pathway that controls glucose uptake in fat and muscle. Rev Endocr Metab Disord 15:55-66
Singh, Rajvir; De Aguiar, Renata Belfort; Naik, Sarita et al. (2013) LRP6 enhances glucose metabolism by promoting TCF7L2-dependent insulin receptor expression and IGF receptor stabilization in humans. Cell Metab 17:197-209
Jastreboff, Ania M; Sinha, Rajita; Lacadie, Cheryl et al. (2013) Neural correlates of stress- and food cue-induced food craving in obesity: association with insulin levels. Diabetes Care 36:394-402
Page, Kathleen A; Chan, Owen; Arora, Jagriti et al. (2013) Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways. JAMA 309:63-70
Page, Kathleen A; Seo, Dongju; Belfort-DeAguiar, Renata et al. (2011) Circulating glucose levels modulate neural control of desire for high-calorie foods in humans. J Clin Invest 121:4161-9
Jastreboff, Ania M; Potenza, Marc N; Lacadie, Cheryl et al. (2011) Body mass index, metabolic factors, and striatal activation during stressful and neutral-relaxing states: an FMRI study. Neuropsychopharmacology 36:627-37
Hens, Julie R; Dann, Pamela; Zhang, Jian-Ping et al. (2007) BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Development 134:1221-30
Ardeshirpour, Laleh; Dann, Pamela; Adams, Douglas J et al. (2007) Weaning triggers a decrease in receptor activator of nuclear factor-kappaB ligand expression, widespread osteoclast apoptosis, and rapid recovery of bone mass after lactation in mice. Endocrinology 148:3875-86
Ardeshirpour, Laleh; Dann, Pamela; Pollak, Martin et al. (2006) The calcium-sensing receptor regulates PTHrP production and calcium transport in the lactating mammary gland. Bone 38:787-93

Showing the most recent 10 out of 22 publications