This proposal seeks continued support for the Yale research-training program in Diabetes Mellitus and Disorders of Metabolism. This program serves as the core source of support for postdoctoral research training in diabetes and endocrinology at the Yale School of Medicine. A major goal of the program is to provide physician-scientists with the research expertise required to pursue clinical, basic and translational research careers in an academic setting. Physician trainees entering the program will have M.D. or M.D./Ph.D. degrees and at least 2-3 years of clinical training in internal medicine or pediatrics. Ph.D. scientists are also recruited into the program since we believe an integrated training experience bringing together adult endocrinologists, pediatric endocrinologists and endocrine scientists is necessary to prepare our trainees to participate in modern multidisciplinary research groups. Trainees are selected based on their aptitude and commitment to a research career. The duration of the training period is three years to ensure an in-depth training experience. The cornerstone of the curriculum is the participation of each trainee in a specific research project under the supervision of a designated preceptor and guided by a progress committee composed of 2-3 other members of the training faculty. Potential projects run the gamut from clinical to basic research in 3 primary areas of emphasis: 1) type 1 diabetes, 2) type 2 diabetes, and 3) bone and mineral metabolism. Within these areas, trainees have the opportunity to work with mentors in several basic science departments as well as those in Pediatrics and Medicine. Close interaction among preceptors and trainees within each programmatic area and within several multidisciplinary and interdepartmental research centers administered within the Endocrine Section further enrich the training experience. Multiple educational opportunities including two degree-granting (MS, PhD) programs are available to trainees through the CTSA-funded Yale Center for Clinical Investigation. Instruction is also provided through organized lectures, research seminars and journal clubs. The application requests an additional training slot per year for a total of 6 stipends. This is based on our decision to fully integrate Yale's pediatric and internal medicine training programs in diabetes and metabolism and, therefore, not to seek renewal of the pediatric T32 (DK63703). It is also based on our ongoing track record of attracting an outstanding applicant pool, the high level of research productivity of our training faculty, the expanded research opportunities provided by our diverse faculty and the continued shortage of physician-scientists in both medicine and pediatrics dedicated to research careers in diabetes and metabolic diseases.

Public Health Relevance

Obesity, diabetes and osteoporosis represent a spectrum of increasingly prevalent metabolic diseases that are responsible for a great burden of suffering and death in the US and throughout the world. Academic endocrine researchers are needed to better understand these disorders and to translate research findings into new therapies. Our training program in diabetes and disorders of metabolism is dedicated to providing young physicians and scientists with the research training necessary to tackle these important health problems.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
3T32DK007058-40S1
Application #
8900676
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
1975-07-01
Project End
2019-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
40
Fiscal Year
2014
Total Cost
$58,625
Indirect Cost
$4,343
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Jeong, Jaekwang; VanHouten, Joshua N; Dann, Pamela et al. (2016) PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer. Proc Natl Acad Sci U S A 113:E282-90
Belfort-DeAguiar, R; Seo, D; Naik, S et al. (2016) Food image-induced brain activation is not diminished by insulin infusion. Int J Obes (Lond) 40:1679-1686
Vatner, Daniel F; Majumdar, Sachin K; Kumashiro, Naoki et al. (2015) Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids. Proc Natl Acad Sci U S A 112:1143-8
Petersen, Max C; Rahimi, Yasmeen; Camporez, Joao-Paulo G et al. (2015) Reply to Constantin-Teodosiu et al.: mice with genetic PDH activation are not protected from high-fat diet-induced muscle insulin resistance. Proc Natl Acad Sci U S A 112:E825
Belman, Jonathan P; Bian, Rachel R; Habtemichael, Estifanos N et al. (2015) Acetylation of TUG protein promotes the accumulation of GLUT4 glucose transporters in an insulin-responsive intracellular compartment. J Biol Chem 290:4447-63
Ardeshirpour, Laleh; Dumitru, Cristina; Dann, Pamela et al. (2015) OPG Treatment Prevents Bone Loss During Lactation But Does Not Affect Milk Production or Maternal Calcium Metabolism. Endocrinology 156:2762-73
Hwang, Janice J; Johnson, Andrea; Cline, Gary et al. (2015) Fructose levels are markedly elevated in cerebrospinal fluid compared to plasma in pregnant women. PLoS One 10:e0128582
Perdigoto, Ana Luisa; Chatenoud, Lucienne; Bluestone, Jeffrey A et al. (2015) Inducing and Administering Tregs to Treat Human Disease. Front Immunol 6:654
Hwang, Janice J; Yeckel, Catherine W; Gallezot, Jean-Dominique et al. (2015) Imaging human brown adipose tissue under room temperature conditions with (11)C-MRB, a selective norepinephrine transporter PET ligand. Metabolism 64:747-55
Hughes, Jing; Vudattu, Nalini; Sznol, Mario et al. (2015) Precipitation of autoimmune diabetes with anti-PD-1 immunotherapy. Diabetes Care 38:e55-7

Showing the most recent 10 out of 39 publications