This proposal seeks continued support for an Institutional NRSA that provides post-doctoral research training to five M.D. and/or Ph.D. trainees in endocrinology, diabetes, and metabolism. This multi-disciplinary program involves 29 faculty preceptors in seven clinical and basic science departments of Vanderbilt University School of Medicine. It is an integral component of the training activities of the Vanderbilt Diabetes Research and Training Center. Its goal is to provide trainees with the knowledge and skills required for independent clinical or basic science research careers. M.D. trainees are encouraged to acquire a firm foundation in the basic sciences, but also to select projects in translational or clinical research areas. Ph.D. trainees are urged to relate their research to health-oriented problems. Trainees are selected from the nationwide pool of applicants that traditionally seek training at Vanderbilt. M.D. trainees usually have two or three years of residency training before entering the program. Ph.D. trainees have typically just received or are one year out from their doctorate. Trainees are selected on the basis of pre-doctoral performance and especially on their potential as future researchers and educators. Training positions are allocated approximately equally between M.D.'s and Ph.D.'s. The training program utilizes the preceptor approach, in which the trainee develops a research project under the guidance of a faculty preceptor. Several criteria are used to match the preceptor with the trainee, including the expressed interests of the trainee, quality of the project proposed, amount of direct supervision that the preceptor can provide, and adequacy of the research facilities available. Typical research topics include hormone action in humans as it relates to diabetes, intermediary metabolism, micronutrient effects on metabolic disease, metabolic regulation, molecular genetics of metabolic diseases, and translation of diabetes care delivery. Research training is supplemented by conferences, seminars, and required and optional coursework. Trainee progress is evaluated by a mentoring committee twice-yearly and the program is evaluated yearly by an oversight committee. In the 31 years of NIH support, the program has supported 96 trainees, and over 70% have chosen careers in academia, industry, or government.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
3T32DK007061-35S2
Application #
7888475
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
1975-07-01
Project End
2011-06-30
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
35
Fiscal Year
2009
Total Cost
$15,755
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Barke, Theresa L; Goldstein, Jeffery A; Sundermann, Alexandra C et al. (2018) Gestational diabetes mellitus is associated with increased CD163 expression and iron storage in the placenta. Am J Reprod Immunol 80:e13020
Hart, Nathaniel J; Aramandla, Radhika; Poffenberger, Gregory et al. (2018) Cystic fibrosis-related diabetes is caused by islet loss and inflammation. JCI Insight 3:
Wilson, Jessica R; Shuey, Megan M; Brown, Nancy J et al. (2017) Hypertension and Type 2 Diabetes Are Associated With Decreased Inhibition of Dipeptidyl Peptidase-4 by Sitagliptin. J Endocr Soc 1:1168-1178
Oelsner, William K; Engstrom, Stephen M; Benvenuti, Michael A et al. (2017) Characterizing the Acute Phase Response in Healthy Patients Following Total Joint Arthroplasty: Predictable and Consistent. J Arthroplasty 32:309-314
Walker, Jennifer M; Dixit, Shilpy; Saulsberry, Anjelica C et al. (2017) Reversal of high fat diet-induced obesity improves glucose tolerance, inflammatory response, ?-amyloid accumulation and cognitive decline in the APP/PSEN1 mouse model of Alzheimer's disease. Neurobiol Dis 100:87-98
Paul, Leena; Walker, Emily M; Drosos, Yiannis et al. (2016) Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine ?-Cells. Diabetes 65:687-98
Wilson, Jessica R; Brown, Nancy J (2016) Examining EXAMINE for an Interaction With Angiotensin-Converting Enzyme Inhibition. Hypertension 68:549-51
Shah, Sapna S; Ramirez, Claudia E; Powers, Alvin C et al. (2016) Hyperglycemic clamp-derived disposition index is negatively associated with metabolic syndrome severity in obese subjects. Metabolism 65:835-42
Wilson, Jessica R; Utz, Andrea L; Devin, Jessica K (2016) Effects of gender, body weight, and blood glucose dynamics on the growth hormone response to the glucagon stimulation test in patients with pituitary disease. Growth Horm IGF Res 26:24-31
Scoville, David W; Cyphert, Holly A; Liao, Lan et al. (2015) MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet ?-Cell Function. Diabetes 64:3772-83

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