This is a proposal for continuation of a long-standing, highly successful research training program for postdoctoral trainees in Digestive Diseases and Nutrition and pre-doctoral trainees in Metabolism and Nutrition. This program's overall goal is to provide rigorous scientific training to highly qualified and promising individuals with a strong commitment to scientific Investigation and academics. Post-doctoral trainees in Digestive Diseases and Nutrition must have a M.D. and/or Ph.D. degree and commitment to careers in academic medicine and sciences. They will be selected by an Executive Committee which includes the Principal Investigator, the Dean of Biological Sciences, the two Co-PIs, and other key members of the training faculty. Candidates for predoctoral training will be selected from the graduate school cluster focused on molecular nutrition and metabolism (Committee on Molecular Metabolism and Nutrition (CMMN)). Appointments will be made by the Executive Committee on the basis of recommendations by the CMMN. This training will be carried out in a highly multidisciplinary and collaborative environment at the University of Chicago that Includes the Gl sections of Medicine and Pediatrics as well as In the Departments of Pathology, Biochemistry &Molecular Biology, Molecular Genetics &Cell Biology, and various other graduate committee programs. In addition, we will continue the highly successful graduate program in Health Studies (toward a Masters degree) which is offered In the clinical scholars post-doctoral training track. Training of both pre- and post-doctoral candidates will consist of 4 major elements: a Research Project performed under the direct supervision of faculty co-mentors;a Core Curriculum of robust seminar series and courses with additional, tailored formal coursework;Learning of Survival Skills that includes scientific communication, grant writing, and mentoring, and a CTSA sponsored Course Series that teaches medical ethic and the responsible conduct of scientific investigation. Incorporated within the training program are oversight mechanisms that ensure high standards of training, monitor trainee progress, and promote career development throughout the training process. In summary, outstanding research facilities, excellence in collaborative and experienced mentorship, and ever increasing scope of research opportunities will prepare trainees well as independent scientists and clinicians for Investigative careers in Digestive Diseases, Metabolism, and Nutrition.

Public Health Relevance

Digestive diseases represent a significant burden of disease and public health problem in the US and worldwide. The objective of this Program Is to prepare young scientists to pursue research careers addressing mechanisms and treatment of human disease, with focus on digestive health and diseases, nutrition, and metabolism. We expect that trainees from this Program to be the future generation of outstanding scientific Investigators, teachers and leaders in digestive health and diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007074-40
Application #
8495313
Study Section
Special Emphasis Panel (ZDK1-GRB-6 (J3))
Program Officer
Densmore, Christine L
Project Start
1975-07-01
Project End
2015-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
40
Fiscal Year
2013
Total Cost
$385,021
Indirect Cost
$24,681
Name
University of Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Dolan, Kyle T; Chang, Eugene B (2017) Diet, gut microbes, and the pathogenesis of inflammatory bowel diseases. Mol Nutr Food Res 61:
Miyoshi, Jun; Bobe, Alexandria M; Miyoshi, Sawako et al. (2017) Peripartum Antibiotics Promote Gut Dysbiosis, Loss of Immune Tolerance, and Inflammatory Bowel Disease in Genetically Prone Offspring. Cell Rep 20:491-504
Huang, Yong; Dalal, Sushila; Antonopoulos, Dionysios et al. (2017) Early Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis. Inflamm Bowel Dis :
Coats, Brittney R; Schoenfelt, Kelly Q; Barbosa-Lorenzi, Valéria C et al. (2017) Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity. Cell Rep 20:3149-3161
Cason, Cori A; Dolan, Kyle T; Sharma, Gaurav et al. (2017) Plasma microbiome-modulated indole- and phenyl-derived metabolites associate with advanced atherosclerosis and postoperative outcomes. J Vasc Surg :
Frazier, Katya; Leone, Vanessa (2017) Keeping Time in a Relay Race for Fat. Cell Host Microbe 22:425-427
Micic, Dejan; Komaki, Yuga; Alavanja, Aleksandar et al. (2017) Risk of Cancer Recurrence Among Individuals Exposed to Antitumor Necrosis Factor Therapy: A Systematic Review and Meta-Analysis of Observational Studies. J Clin Gastroenterol :
Miyoshi, Jun; Chang, Eugene B (2017) The gut microbiota and inflammatory bowel diseases. Transl Res 179:38-48
Busch, Rebecca A; Heneghan, Aaron F; Pierre, Joseph F et al. (2016) Bombesin Preserves Goblet Cell Resistin-Like Molecule ? During Parenteral Nutrition but Not Other Goblet Cell Products. JPEN J Parenter Enteral Nutr 40:1042-9
Howe, Adina; Ringus, Daina L; Williams, Ryan J et al. (2016) Divergent responses of viral and bacterial communities in the gut microbiome to dietary disturbances in mice. ISME J 10:1217-27

Showing the most recent 10 out of 74 publications