This is a proposal for continuation of a long-standing, highly successful research training program for postdoctoral trainees in Digestive Diseases and Nutrition and pre-doctoral trainees in Metabolism and Nutrition. This program's overall goal is to provide rigorous scientific training to highly qualified and promising individuals with a strong commitment to scientific Investigation and academics. Post-doctoral trainees in Digestive Diseases and Nutrition must have a M.D. and/or Ph.D. degree and commitment to careers in academic medicine and sciences. They will be selected by an Executive Committee which includes the Principal Investigator, the Dean of Biological Sciences, the two Co-PIs, and other key members of the training faculty. Candidates for predoctoral training will be selected from the graduate school cluster focused on molecular nutrition and metabolism (Committee on Molecular Metabolism and Nutrition (CMMN)). Appointments will be made by the Executive Committee on the basis of recommendations by the CMMN. This training will be carried out in a highly multidisciplinary and collaborative environment at the University of Chicago that Includes the Gl sections of Medicine and Pediatrics as well as In the Departments of Pathology, Biochemistry &Molecular Biology, Molecular Genetics &Cell Biology, and various other graduate committee programs. In addition, we will continue the highly successful graduate program in Health Studies (toward a Masters degree) which is offered In the clinical scholars post-doctoral training track. Training of both pre- and post-doctoral candidates will consist of 4 major elements: a Research Project performed under the direct supervision of faculty co-mentors;a Core Curriculum of robust seminar series and courses with additional, tailored formal coursework;Learning of Survival Skills that includes scientific communication, grant writing, and mentoring, and a CTSA sponsored Course Series that teaches medical ethic and the responsible conduct of scientific investigation. Incorporated within the training program are oversight mechanisms that ensure high standards of training, monitor trainee progress, and promote career development throughout the training process. In summary, outstanding research facilities, excellence in collaborative and experienced mentorship, and ever increasing scope of research opportunities will prepare trainees well as independent scientists and clinicians for Investigative careers in Digestive Diseases, Metabolism, and Nutrition.

Public Health Relevance

Digestive diseases represent a significant burden of disease and public health problem in the US and worldwide. The objective of this Program Is to prepare young scientists to pursue research careers addressing mechanisms and treatment of human disease, with focus on digestive health and diseases, nutrition, and metabolism. We expect that trainees from this Program to be the future generation of outstanding scientific Investigators, teachers and leaders in digestive health and diseases.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZDK1-GRB-6 (J3))
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Densmore, Christine L
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University of Chicago
Internal Medicine/Medicine
Schools of Medicine
United States
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Zhai, Zili; Wu, Feng; Dong, Fengshi et al. (2014) Human autophagy gene ATG16L1 is post-transcriptionally regulated by MIR142-3p. Autophagy 10:468-79
Chuang, Alice Y; Chuang, Jim C; Zhai, Zili et al. (2014) NOD2 expression is regulated by microRNAs in colonic epithelial HCT116 cells. Inflamm Bowel Dis 20:126-35
Leone, Vanessa A; Cham, Candace M; Chang, Eugene B (2014) Diet, gut microbes, and genetics in immune function: can we leverage our current knowledge to achieve better outcomes in inflammatory bowel diseases? Curr Opin Immunol 31:16-23
Dalal, Sushila R; Chang, Eugene B (2014) The microbial basis of inflammatory bowel diseases. J Clin Invest 124:4190-6
Zhai, Zili; Wu, Feng; Chuang, Alice Y et al. (2013) miR-106b fine tunes ATG16L1 expression and autophagic activity in intestinal epithelial HCT116 cells. Inflamm Bowel Dis 19:2295-301
Leone, Vanessa; Chang, Eugene B; Devkota, Suzanne (2013) Diet, microbes, and host genetics: the perfect storm in inflammatory bowel diseases. J Gastroenterol 48:315-21
Huang, Edmond Y; Leone, Vanessa A; Devkota, Suzanne et al. (2013) Composition of dietary fat source shapes gut microbiota architecture and alters host inflammatory mediators in mouse adipose tissue. JPEN J Parenter Enteral Nutr 37:746-54
Zheng, Wei; Wong, Kari E; Zhang, Zhongyi et al. (2012) Inactivation of the vitamin D receptor in APC(min/+) mice reveals a critical role for the vitamin D receptor in intestinal tumor growth. Int J Cancer 130:10-9
Raleigh, David R; Boe, Devin M; Yu, Dan et al. (2011) Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function. J Cell Biol 193:565-82
Wong, Kari E; Kong, Juan; Zhang, Wenshuo et al. (2011) Targeted expression of human vitamin D receptor in adipocytes decreases energy expenditure and induces obesity in mice. J Biol Chem 286:33804-10

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