Established in 1975, the Diabetes and Related Metabolic Diseases Training Grant at Washington University has a track record of training biomedical scientists who have made important contributions. The goal of this Training Program is to identify individuals of diverse backgrounds who are committed to a career in biomedical/clinical research, and provide them with a mentored postdoctoral research experience for a minimum of two years that will establish a foundation for an independent research program capable of translational research in diabetes and related metabolic diseases. In recognition of the growing impact of diabetes and related disorders on Americans as well as the shrinking pool of young investigators trained to pursue clinically relevant diabetes reserch, this training program has been re-structured to satisfy the need for diabetes researchers committed to translating findings at the bench to new therapies in the clinic with the potential to improve diabetes care. Changes include focusing the scientific efforts of the Program Faculty, emphasing translational research training (including training with a clinical context to PhD scientists in addition to MD and MD/PhD scientists), instituting a regular research symposium, establishing a formal mentoring system that includes a Career Development Committee for each fellow, expanding didactic training, instituting a formal evaluation system for the program, instituting formal training in ethics, developing targeted recruitment strategies to improve our yield of promising physician scientists, and developing a minority recruitment strategy with the assistance of the Associate Dean and Director of the Office of Diversity. This Training Program combines a talented and dedicated faculty, a substantial pool of promising trainees, and a culture of interdisciplinary scientific diversity and collaboration creating an ideal environment for training in Diabetes and Related Metabolic Diseases.

Public Health Relevance

This application is directly relevant to public health and the mission of the NIDDK. Diabetes and related metabolic diseases extract a terrible burden on the American public despite staggering health care expenditures for these problems. Training biomedical scientists to perform paradigm-shifting translational research has the potential to decrease this burden through development of novel therapies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007120-40
Application #
8697038
Study Section
Digestive Diseases and Nutrition C Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
1975-07-01
Project End
2015-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
40
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Semenkovich, Clay F (2017) We Know More Than We Can Tell About Diabetes and Vascular Disease: The 2016 Edwin Bierman Award Lecture. Diabetes 66:1735-1741
Williams, Jesse W; Elvington, Andrew; Ivanov, Stoyan et al. (2017) Thermoneutrality but Not UCP1 Deficiency Suppresses Monocyte Mobilization Into Blood. Circ Res 121:662-676
McCommis, Kyle S; Hodges, Wesley T; Brunt, Elizabeth M et al. (2017) Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis. Hepatology 65:1543-1556
Borschel, William F; Wang, Shizhen; Lee, Sunjoo et al. (2017) Control of Kir channel gating by cytoplasmic domain interface interactions. J Gen Physiol 149:561-576
Cipolla, Cynthia M; Lodhi, Irfan J (2017) Peroxisomal Dysfunction in Age-Related Diseases. Trends Endocrinol Metab 28:297-308
Vigueira, Patrick A; McCommis, Kyle S; Hodges, Wesley T et al. (2017) The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism. Exp Physiol 102:985-999
Griffin, Nicholas W; Ahern, Philip P; Cheng, Jiye et al. (2017) Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions. Cell Host Microbe 21:84-96
Fabbrini, Elisa; Tiemann Luecking, Courtney; Love-Gregory, Latisha et al. (2016) Physiological Mechanisms of Weight Gain-Induced Steatosis in People With Obesity. Gastroenterology 150:79-81.e2
Kim, Ki-Wook; Williams, Jesse W; Wang, Ya-Ting et al. (2016) MHC II+ resident peritoneal and pleural macrophages rely on IRF4 for development from circulating monocytes. J Exp Med 213:1951-9
Ivanov, Stoyan; Scallan, Joshua P; Kim, Ki-Wook et al. (2016) CCR7 and IRF4-dependent dendritic cells regulate lymphatic collecting vessel permeability. J Clin Invest 126:1581-91

Showing the most recent 10 out of 113 publications